Schiff Bases: Multipurpose Pharmacophores with Extensive Biological Applications

Abstract

Schiff bases are substances prepared generally by the condensation reaction of aldehydes or ketones with amines. They may have substituted aliphatic or aromatic side chains, and hence show extensive biological activities. It is reported that these molecules play an important role in the synthesis of various drugs. This paper focus on the biological activities of Schiff bases of various types and hence makes them important precursors in designing drugs for medical treatment. The biological applications of Schiff bases can be extended from antimicrobial, plant growth regulator, antioxidant, enzymatic, anticancer, anti-inflammatory, anti-malarial, antiviral, neuroprotective, analgesic, anti-convulsant to neurotoxic activities. They also serve as a dominant class of ligands with a variety of binding sites for coordination with metals.

RETRACTED ARTICLE: Gastroprotective activity of a novel Schiff base derived dibromo substituted compound against ethanol-induced acute gastric lesions in rats

“…Some chemical compounds, such as phenolic, flavonoids, metallic and nonmetallic organic derivatives and heterocycles, Schiff bases, etc., possess anti gastric ulcer activity [3, 4]. Schiff bases are synthesized by reaction of primary amines with carbonyl compounds [5].…”

“…Chelation of such compounds with some metals [6–8], halogens [9, 10], oxygen [11], etc. demonstrated to have applications as drugs and possess many biological activities, such as, anti-viral [4], anti-bacteria [11], gastroprotective activity [12], antioxidant [13], anti-inflammation [14] and anti-tumors [15]. Specifically, it is noted that bromine substituted complex of Schiff bases exhibits excellent activity against gastro ulcer in rodents [16].…”

Synthesis, Crystal Structure, Hirshfeld Surface Analysis, and Computational Study of a Novel Organic Salt Obtained from Benzylamine and an Acidic Component

“…Schiff bases are getting increasing interest nowadays because of their versatile applications in various fields. 1 These are usually prepared by the condensation of aldehydes and/or ketones with primary amines in a simple way with high yield. 2 The Schiff bases derived from aromatic aldehydes are more stable due to the presence of conjugation as compared to those which were prepared from aliphatic aldehydes.…”

Schiff Bases as Important Class of Pharmacological Agents

“…Cryptolepine, valid indolchinoline alkaloid, isolated from African plant Cryptolepis sanguinolenta and used in the treatment of malaria, is the product of multi-stage reaction, in which Schiff base is involved ( Fig. 23) [8,69].…”