Schisandra chinensis extract decreases chloroacetaldehyde production in rats and attenuates cyclophosphamide toxicity in liver, kidney and brain

Zhai, Jianxiu; zhang, Feng; Gao, Shouhong; Chen, Li; Feng, Ge; Yin, Jun; Chen, Wansheng

doi:10.1016/j.jep.2017.08.020

Cited by 56 publications

(33 citation statements)

References 35 publications

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“…There is little understanding of the influence of alkylating agents on the pituitary. Some previous studies reported that cyclophosphamide induced oxidative stress in the brain of mice [22,23], and Ayoka et al reported that the parenchymal cells appeared scanty and hypertrophied in the pituitary of mice exposed to cyclophosphamide [24]. We deduced that the alteration of the histoarchitecture of the pituitary may lead to GHD.…”

Section: Discussionmentioning

confidence: 65%

Factors predicting endocrine late effects in childhood cancer survivors from a Japanese hospital

et al. 2020

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We retrospectively analyzed endocrine late effects in 81 childhood cancer survivor (CCS) patients who had been referred to our endocrinology department in Chiba Children's Hospital between January 1, 2008 and December 31, 2016. Among 69 eligible patients (33 male, 36 female), endocrine late effects were identified in 56 patients (81.1%). The median age at the last visit to our endocrinology department was 17.4 years (range: 7.1-35.3 years). The most common primary cancer was acute lymphoblastic leukemia (22 patients, 31.8%). Forty-four patients (64%) were treated using radiation therapy. A primary brain tumor and high doses (≥6 g/m 2 ) of cyclophosphamide were significantly associated with growth hormone deficiency (GHD). Our present study suggests that high doses of cyclophosphamide is a risk factor for GHD. Adult heights and pubertal growth spurts of patients treated with radiation therapy were significantly lower than patients not treated with radiation therapy. Our retrospective study reconfirmed that hematopoietic stem cell transplantation and chronic graft versus host disease (GVHD) were associated with elevated risks of primary hypothyroidism. However, it is unclear whether GVHD induces thyroid dysfunction. Gonadal radiation and busulfan were associated with primary hypogonadism as reported in previous studies. We found high doses of cyclophosphamide to be involved in pituitary disorders. We suggest that pediatric endocrinologists should discuss the potential effects of radiation therapy on adult height and pubertal growth spurt in CCS patients. Moreover, patients who have been treated with high doses of cyclophosphamide or have chronic GVHD require long-term follow-up for endocrine late effects.

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Section: Discussionmentioning

confidence: 65%

Factors predicting endocrine late effects in childhood cancer survivors from a Japanese hospital

et al. 2020

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“…Oxidative stress and inflammation have been implicated in neurodegeneration, including cognitive impairment [26]. SC has been extensively studied for its immunomodulatory, antioxidant, anticancer, and cognition/memory-improving activities [10,11,27,28]. In addition, SC has been shown to protect the liver, kidney, and nervous system in cyclophosphamide-treated rats [27].…”

Section: Discussionmentioning

confidence: 99%

Synergistic Neuroprotective Effect of Schisandra chinensis and Ribes fasciculatum on Neuronal Cell Death and Scopolamine-Induced Cognitive Impairment in Rats

Park

Ryu

Kim

et al. 2019

IJMS

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Mild cognitive impairment (MCI) is considered as a transitional stage between aging and Alzheimer’s disease. In the present study, we examined the protective effect of Schisandra chinensis (SC) and Ribes fasciculatum (RF) on neuronal cell death in vitro and scopolamine-induced cognitive impairment in Sprague Dawley® rats in vivo. A mixture of SC and RF extracts (SC+RF) significantly protected against hydrogen peroxide-induced PC12 neuronal cell death. The neuroprotective effect of SC+RF on scopolamine-induced memory impairment in rats was evaluated using the passive avoidance test and the Morris water maze test. In the passive avoidance test, SC+RF-treated rats showed an increased latency to escape, compared to the scopolamine-treated rats. Moreover, SC+RF treatment significantly reduced escape latency in water maze test, compared to treatment with scopolamine alone. To verify the long-term memory, we performed probe test of water maze test. As a result, rat treated with SC+RF spent more time in the target quadrant. Consistent with enhancement of memory function, the brain derived neurotrophic factor (BDNF) and its downstream molecules (pERK, pATK, and pCREB) are increased in SC+RF treatment in hippocampal area compared with scopolamine treated group. These results suggest that a mixture of SC and RF extracts may be a good therapeutic candidate for preventing mild cognitive impairment.

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“…It plays an important role in regulating the body’s water, salt, and ion balance [ 1 , 2 ]. Cyclophosphamide (CTX) is widely used as an anticancer drug [ 3 , 4 ], although it can cause side effects such as cardiotoxicity, nephrotoxicity, and hepatotoxicity. The process of CTX-induced renal pathological damage includes apoptosis and necrosis of renal tubular epithelial cells [ 5 ], release of inflammatory factors, and mediation of inflammatory response [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Ameliorating Effect of Pentadecapeptide Derived from Cyclina sinensis on Cyclophosphamide-Induced Nephrotoxicity

et al. 2020

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Cyclophosphamide (CTX) is a widely used anticancer drug with severe nephrotoxicity. The pentadecapeptide (RVAPEEHPVEGRYLV) from Cyclina sinensis (SCSP) has been shown to affect immunity and to protect the liver. Hence, the purpose of this study was to investigate the ameliorating effect of SCSP on CTX-induced nephrotoxicity in mice. We injected male ICR mice with CTX (80 mg/kg·day) and measured the nephrotoxicity indices, levels of antioxidant enzymes, malondialdehyde (MDA), inflammatory factors, as well as the major proteins of the NF-κB and apoptotic pathways. Cyclophosphamide induced kidney injury; the levels of kidney-injury indicators and cytokines recovered remarkably in mice after receiving SCSP. The activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) increased, while there was a significant decrease in MDA levels. The kidney tissue damage induced by CTX was also repaired to a certain extent. In addition, SCSP significantly inhibited inflammatory factors and apoptosis by regulating the NF-κB and apoptotic pathways. Our study shows that SCSP has the potential to ameliorate CTX-induced nephrotoxicity and may be used as a therapeutic adjuvant to ameliorate CTX-induced nephrotoxicity.

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Schisandra chinensis extract decreases chloroacetaldehyde production in rats and attenuates cyclophosphamide toxicity in liver, kidney and brain

Cited by 56 publications

References 35 publications

Factors predicting endocrine late effects in childhood cancer survivors from a Japanese hospital

Factors predicting endocrine late effects in childhood cancer survivors from a Japanese hospital

Synergistic Neuroprotective Effect of Schisandra chinensis and Ribes fasciculatum on Neuronal Cell Death and Scopolamine-Induced Cognitive Impairment in Rats

Ameliorating Effect of Pentadecapeptide Derived from Cyclina sinensis on Cyclophosphamide-Induced Nephrotoxicity

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