Schisandra chinensis polysaccharide protects against cyclosporin A-induced liver injury by promoting hepatocyte proliferation

Wu, Quanwu; Liu, Chang; Zhang, Jianing; Xiao, Wen; Yang, Fang; Yu, Yang; Li, Tongming; Wang, Yumei

doi:10.1016/j.jff.2021.104799

Cited by 11 publications

(4 citation statements)

References 35 publications

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“…Schisandra chinensis, a classic medicinal and edible homologous plant, is used to treat ischemic heart disease and prevent liver injury. , However, most of the research on the active ingredients of Schisandra chinensis is currently in the lignan stage . Numerous investigations have indicated that the polysaccharide of Schisandra chinensis also has affluent pharmacological activities, such as antioxidant, antidepressant, anticardiac hypertrophy, and antiosteoporosis effects. ,, Therefore, the structural characterization of the Schisandra chinensis polysaccharide is particularly important (Figure C).…”

Section: Resultsmentioning

confidence: 99%

A Reverse Thinking Based on Partially Methylated Aldononitrile Acetates to Analyze Glycoside Linkages of Polysaccharides Using Liquid Chromatography–Multiple Reaction Monitoring Mass Spectrometry

Gao,

Li,

Liang

et al. 2024

J. Agric. Food Chem.

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Glycoside linkage analyses of medicine and food homologous plant polysaccharides have always been a key point and a difficulty of structural characterization. The gas chromatography−mass spectrometry (GC-MS) method is one of the commonly used traditional techniques to determine glycoside linkages via partially methylated alditol acetates and aldononitrile acetates (PMAAs and PMANs). Due to the simplicity of derivatization and the highly structural asymmetry of PMANs, reverse thinking is proposed using liquid chromatography−electrospray ionization−multiple reaction monitoring mass spectrometry (LC-ESI-MRM-MS) for the first time to directly determine the neutral and acidic glycosyl linkages of polysaccharides. The complete characterization of glycoside linkages deduced from PMANs was achieved using a combination of t R values, characteristic MRM ion pairs, diagnostic ESI + −MS/MS fragmentation ions (DFIs), and optimal collision energy (OCE). The DFI and OCE parameters were confirmed to be effective for the auxiliary discrimination of some isomers of the PMANs. The practicality of LC-ESI + -MRM-MS was further verified by analyzing the glycoside linkages of polysaccharides in five medicine and food homologous plants. This method can serve as an alternative to GC-MS for the simultaneous determination of neutral and acidic glycosyl linkages in polysaccharides.

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Section: Resultsmentioning

confidence: 99%

A Reverse Thinking Based on Partially Methylated Aldononitrile Acetates to Analyze Glycoside Linkages of Polysaccharides Using Liquid Chromatography–Multiple Reaction Monitoring Mass Spectrometry

Gao,

Li,

Liang

et al. 2024

J. Agric. Food Chem.

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“…Glc p residues revealed as T-Glc p -(1→, →2)-Glc p -(1→, →4)-Glc p -(1→, →6)-Glc p -(1→, →3,4)-Glc p -(1→ and →4,6)-Glc p -(1→ ( 49 , 50 , 93 , 94 ). Man p residues behaved as T-Man p -(1→, →2)-Man p -(1→, →4)-Man p -(1→, →6)-Man p -(1→ and →3,6)-Man p -(1→ ( 46 , 73 , 74 , 92 ). Xyl p residues manifested as T-Xyl p -(1→, →3)-Xyl p -(1→ and →4)-Xyl p -(1→ ( 73 , 74 , 87 , 88 ).…”

Section: Structural Features Of Nps Having Regulation On Nrf2 Antioxi...mentioning

confidence: 99%

“…Cell experiments have indicated that NPs from woody plants could regulate Nrf2 antioxidant pathway for liver protection ( 30 , 45 , 46 , 50 , 70 , 92 , 172 ), kidney protection ( 173 ), gastrointestinal protection ( 86 ), neuroprotection ( 75 ), cardioprotection ( 78 ), anti-aging ( 74 ), anti-diabetic ( 174 ), anti-oxidation ( 72 , 96 , 175 ), and anti-inflammation ( 71 ), as showed in Table 2 .…”

Section: Regulation Of Nps On Nrf2 Antioxidant Pathway For Health-pro...mentioning

confidence: 99%

“…Natural polysaccharides from woody plants exhibited liver protection against H 2 O 2 -induced primary hepatocytes from hybrid grouper ( 30 ), H 2 O 2 -induced AML12 cells ( 50 ), CCl 4 - ( 70 ) and palmitic acid-induced ( 45 , 46 ) HepG2 cells, cyclosporin A-induced LX-2 cells ( 92 ), and hepatocytes isolated from high-fat diet-induced hybrid grouper ( 172 ), involving with increments of mRNA and protein expressions of p-Nrf2, nuclear Nrf2, Nrf2, HO-1, NQO1, γ-GCL, GCLC, Mn-SOD, GPX, and CAT as well as nuclear translocation of Nrf2, and reduction of GR mRNA expression. Schisandra chinensis polysaccharide generated kidney protection on 293T cells through increasing protein expressions of nuclear Nrf2, Nrf2, NQO1, and HO-1 along with NQO1-antioxidant response element-luciferase activity, and decreasing protein expressions of cytosol Keap1 and Nrf2 ( 173 ).…”

Section: Regulation Of Nps On Nrf2 Antioxidant Pathway For Health-pro...mentioning

confidence: 99%

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Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway

Luo

Shen

et al. 2023

Front. Nutr.

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Natural polysaccharides (NPs) possess numerous health-promoting effects, such as liver protection, kidney protection, lung protection, neuroprotection, cardioprotection, gastrointestinal protection, anti-oxidation, anti-diabetic, and anti-aging. Nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant pathway is an important endogenous antioxidant pathway, which plays crucial roles in maintaining human health as its protection against oxidative stress. Accumulating evidence suggested that Nrf2 antioxidant pathway might be one of key regulatory targets for the health-promoting effects of NPs. However, the information concerning regulation of NPs on Nrf2 antioxidant pathway is scattered, and NPs show different regulatory behaviors in their different health-promoting processes. Therefore, in this article, structural features of NPs having regulation on Nrf2 antioxidant pathway are overviewed. Moreover, regulatory effects of NPs on this pathway for health-promoting effects are summarized. Furthermore, structure-activity relationship of NPs for health-promoting effects by regulating the pathway is preliminarily discussed. Otherwise, the prospects on future work for regulation of NPs on this pathway are proposed. This review is beneficial to well-understanding of underlying mechanisms for health-promoting effects of NPs from the view angle of Nrf2 antioxidant pathway, and provides a theoretical basis for the development and utilization of NPs in promoting human health.

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Structure of a highly branched galacturonoglucan from fruits of Schisandra chinensis (Turcz.) Baill.

Huang

Liang

Chai

et al. 2023

Carbohydrate Polymers

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Schisandra chinensis polysaccharide protects against cyclosporin A-induced liver injury by promoting hepatocyte proliferation

Cited by 11 publications

References 35 publications

A Reverse Thinking Based on Partially Methylated Aldononitrile Acetates to Analyze Glycoside Linkages of Polysaccharides Using Liquid Chromatography–Multiple Reaction Monitoring Mass Spectrometry

A Reverse Thinking Based on Partially Methylated Aldononitrile Acetates to Analyze Glycoside Linkages of Polysaccharides Using Liquid Chromatography–Multiple Reaction Monitoring Mass Spectrometry

Advances in health-promoting effects of natural polysaccharides: Regulation on Nrf2 antioxidant pathway

Structure of a highly branched galacturonoglucan from fruits of Schisandra chinensis (Turcz.) Baill.

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