Schisandrin A ameliorates airway inflammation in model of asthma by attenuating Th2 response

Qiu, Qingtao; Zhang, Weizhen; Liu, Ke; Huang, Fangfang; Su, Jiating; Deng, Liyan; He, Juan; Qianwen, Lin; Luo, Lianxiang

doi:10.1016/j.ejphar.2023.175850

Cited by 8 publications

(2 citation statements)

References 71 publications

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“…Schisandra chinensis contains a significant amount of pharmacologically active components, with the majority being phenolic substances such as flavonoids, lignans, and anthocyanins. Lignan is the main pharmacologically active ingredient in Schisandra chinensis; it has shown a good curative effect on many diseases [3][4][5][6][7]. Therefore, this experiment conducted an in-depth study on lignans.…”

Section: Analysis Of Lignans In Fruit Of Schisandra Chinensis At Diff...mentioning

confidence: 99%

“…Additionally, schisandrin A is recognized for attenuating ferroptosis and necroptosis triggered by hyperglycemia, conferring anti-inflammatory advantages and presenting a potential diabetes therapy [4]. Moreover, schisandrin A has been reported to mitigate asthma symptoms through its anti-inflammatory action [5]. Schisantherin A markedly curtails oxidative stress and inflammation induced by isoproterenol, offering prophylactic protection against myocardial infarction-induced cardiac injury [6].…”

Section: Introductionmentioning

confidence: 99%

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Based on HPLC and HS-GC-IMS Techniques, the Changes in the Internal Chemical Components of Schisandra chinensis (Turcz.) Baill. Fruit at Different Harvesting Periods Were Analyzed

Sun,

Yan,

et al. 2024

Molecules

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Schisandra chinensis, as a traditional Chinese herbal medicine, has clear pharmacological effects such as treating asthma, protecting nerves and blood vessels, and having anti-inflammatory properties. Although the Schisandra chinensis fruit contain multiple active components, the lignans have been widely studied as the primary pharmacologically active compound. The volatile chemical components of Schisandra chinensis include a large amount of terpenes, which have been proven to have broad pharmacological activities. However, when to harvest to ensure the highest accumulation of pharmacologically active components in Schisandra chinensis fruits is a critical issue. The Schisandra chinensis fruit trees in the resource nursery were all planted in 2019 and began bearing fruit in 2021. Their nutritional status and tree vigor remain consistently good. The content of lignans and organic acids in the fruits of Schisandra chinensis over seven different harvest periods was tested, and the results of high-performance liquid chromatography (HPLC) indicated that the lignan content was higher, at 35 mg/g, in late July, and the organic acid content was higher, at 72.34 mg/g, in early September. If lignans and organic acids are to be selected as raw materials for pharmacological development, the harvest can be carried out at this stage. Using HS-GC-IMS technology, a total of 67 volatile flavor substances were detected, and the fingerprint of the volatile flavor substances in the different picking periods was established. It was shown by the results that the content of volatile flavor substances was the highest in early August, and 16 flavor substances were selected by odor activity value (OAV). The variable importance in projection (VIP) values of 16 substances were further screened, and terpinolene was identified as the key volatile flavor substance that caused the aroma characteristics of Schisandra chinensis fruit at different harvesting periods. If the aroma component content of Schisandra chinensis fruit is planned to be used as raw material for development and utilization, then early August, when the aroma component content is higher, should be chosen as the time for harvest. This study provides a theoretical basis for the suitable harvesting time of Schisandra chinensis for different uses, and promotes the high-quality development of the Schisandra chinensis industry.

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Section: Analysis Of Lignans In Fruit Of Schisandra Chinensis At Diff...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Based on HPLC and HS-GC-IMS Techniques, the Changes in the Internal Chemical Components of Schisandra chinensis (Turcz.) Baill. Fruit at Different Harvesting Periods Were Analyzed

Sun,

Yan,

et al. 2024

Molecules

View full text Add to dashboard Cite

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The inhibitory impact of Schisandrin on inflammation and oxidative stress alleviates LPS‐induced acute kidney injury

Liu,

Huang,

et al. 2024

Biotech and App Biochem

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Inflammation and oxidative stress (OS) are the major pathogenic characteristics of acute kidney injury (AKI). Studies have shown that Schisandrin (Sch) could regulate inflammatory disease. However, the function and mechanism of Sch in AKI progression are still unknown. Here, we investigated Sch's potential effects and mechanism on mice's renal damage and macrophages induced by lipopolysaccharide (LPS). Sch decreased LPS‐induced inflammatory factor production while increasing the activity of related antioxidant enzymes in macrophages and mouse kidney tissues. Hematoxylin and eosin staining revealed that Sch may have the ability to profoundly inhibit inflammatory cell invasion and tissue damage caused by LPS in renal tissue. Furthermore, Western blot and immunohistochemical studies showed that Sch exerted its effects mainly through up‐regulation of nuclear factor erythroid 2‐related factor 2/heme oxygenase‐1 and inhibition of Toll‐like receptor 4‒mitogen‐activated protein kinases/nuclear factor‐kappa B pathways. Collectively, this study illustrates that Sch suppresses LPS‐stimulated AKI by descending inflammation and OS, illuminating prospective AKI treatment options.

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Extraction, purification, structural characterization, and bioactivities of the genus Schisandra polysaccharides: A review

Chen,

Qin,

Yang

et al. 2024

International Journal of Biological Macromolecules

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Schisandrin A ameliorates airway inflammation in model of asthma by attenuating Th2 response

Cited by 8 publications

References 71 publications

Based on HPLC and HS-GC-IMS Techniques, the Changes in the Internal Chemical Components of Schisandra chinensis (Turcz.) Baill. Fruit at Different Harvesting Periods Were Analyzed

Based on HPLC and HS-GC-IMS Techniques, the Changes in the Internal Chemical Components of Schisandra chinensis (Turcz.) Baill. Fruit at Different Harvesting Periods Were Analyzed

The inhibitory impact of Schisandrin on inflammation and oxidative stress alleviates LPS‐induced acute kidney injury

Extraction, purification, structural characterization, and bioactivities of the genus Schisandra polysaccharides: A review

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