2021
DOI: 10.3892/or.2021.8066
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Schisandrin B inhibits epithelial‑mesenchymal transition and stemness of large‑cell lung cancer cells and tumorigenesis in xenografts via inhibiting the NF‑κB and p38 MAPK signaling pathways

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Cited by 18 publications
(14 citation statements)
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“…Schisandrin B significantly suppressed the levels of CD133, CD44, OCT4 and Bmi-1 in the tumor tissues. Moreover, Schisandrin B significantly reduced p-IκBα, p-p65 and p-p38MAPK in the tumor tissues of xenografted mice (37).…”
Section: Tumor Suppressive Mirnasmentioning
confidence: 87%
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“…Schisandrin B significantly suppressed the levels of CD133, CD44, OCT4 and Bmi-1 in the tumor tissues. Moreover, Schisandrin B significantly reduced p-IκBα, p-p65 and p-p38MAPK in the tumor tissues of xenografted mice (37).…”
Section: Tumor Suppressive Mirnasmentioning
confidence: 87%
“…Schisandrin B upregulated E-cadherin and downregulated vimentin and N-cadherin in H661-CSCs and NCI-H460-CSCs (Li,37). Schisandrin B efficiently suppressed CD133, CD44, OCT4 and Bmi-1 in cancer stem cells.…”
Section: Tumor Suppressive Mirnasmentioning
confidence: 99%
“…Similarly, Man-BSA treatment had no effects on levels of TNF-α and IL-6 when compared with LPS treatment. The signal pathways involved in macrophage activation and inflammatory responses mainly included the NF-κB and MAPK signaling pathways (Li et al, 2021;Smith and Burger, 2021). Therefore, we evaluated the effects of the above treatments on the expression of p65 and IκB-α (key regulators of NF-κB pathway) and JNK and p38 (key regulators of MAPK pathway) proteins.…”
Section: Anti-inflammatory Activity Of Man-bsa@rb1 Nps In Vitromentioning
confidence: 99%
“…13 Some ingredients of AR and SCF have been reported to have functions on NSCLC. [14][15][16] The functions of the Qi Wei Wan (QWW) formula (composed of AR and SCF) have been documented in "Pu Ji Fang" (Prescriptions of Universal Relief, 1406). It is described as a supplement for the treatment of blood deficiency syndrome.…”
Section: Introductionmentioning
confidence: 99%