Schisandrin C Affects Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells and Glucose Uptake in Skeletal Muscle Cells

Lee, Dahae; Kim, Youngmi; Kim, Hyun Woo; Choi, You-Kyoung; Park, Bang Ju; Joo, Sang Hoon; Kang, Ki Sung

doi:10.3390/molecules26216509

Cited by 6 publications

(2 citation statements)

References 38 publications

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“…In addition to the aforementioned pharmacological activities, Sch C was also found to have antiviral activity, [89] and experiments showed that Sch C reduced HBeAg, HBcAg, HBsAg and HBV DNA levels in HBV model mice and increased IFN β production and expression of interferon-stimulated genes (IFIT1, ISG15 and CXCL10). In contrast, a study by D. Lee [90] illustrated that Sch C is also effective in hypoglycemia, enhancing insulin secretion in response to high glucose levels, with no toxic effects on INS-1 cells and better effects than gliclazide (positive control), while enhancing glucose uptake.…”

Section: Othersmentioning

confidence: 95%

A Review of Extraction and Purification, Biological Properties, Structure–Activity Relationships and Future Prospects of Schisandrin C: A Major Active Constituent of Schisandra Chinensis

Xu,

Wang,

et al. 2023

Chemistry & Biodiversity

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Since ancient times, China has used natural medicine as the primary way to combat diseases and has a rich arsenal of natural medicines. With the progress of the times, the extraction of bioactive molecules from natural drugs has become the new development direction for natural medicines. Among the numerous natural drugs, Schisandrin C (Sch C), derived from Schisandra Chinensis (Turcz.) Baill. It has excellent potential for development and has been shown to possess various pharmacological properties, including hepatoprotective, antitumor and anti‐inflammatory activities. Based on the biological properties of hepatoprotection, scholars have explored Sch C and its synthetic products in depth; some studies have shown that pentosidine has the effect of improving the symptoms of liver fibrosis and reducing the concentration of alanine transaminase (ALT) and aspartate aminotransferase (AST) in the serum of rats, which is an essential inspiration for the development of anti‐liver fibrosis drugs. But more in vivo and ex vivo studies still need to be included. This paper focuses on Sch C′s extraction and synthesis, biological activities and drug development progress. The future application prospects of Sch C are discussed to perfect its development work further.

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Section: Othersmentioning

confidence: 95%

A Review of Extraction and Purification, Biological Properties, Structure–Activity Relationships and Future Prospects of Schisandrin C: A Major Active Constituent of Schisandra Chinensis

Xu,

Wang,

et al. 2023

Chemistry & Biodiversity

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“…QKF Improves STZ-Induced Mouse Inflammation. DOP is an inflammatory response caused by high blood glucose [15]. To validate that QKF could reduce the inflammatory expression of STZ-induced mice, we used qRT-PCR and Western blot to determine changes in mRNA and protein levels (Figure 4).…”

Section: Effect Of Qkf On the General Features Of Stz-inducedmentioning

confidence: 99%

Qizhi Kebitong Formula Ameliorates Streptozocin‐Induced Diabetic Osteoporosis through Regulating the PI3K/Akt/NF‐κB Pathway

Tian

Ding

Wang

et al. 2022

BioMed Research International

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Background. Diabetic osteoporosis (DOP) is a progressive osteoblast dysfunction induced by high glucose, which has negative impacts on bone homeostasis. Qizhi Kebitong formula (QKF) is a traditional Chinese medicine (TCM) formula for treating DOP. However, its role in the protection of DOP has not been clarified yet. Here, we aimed to explore the potential mechanisms of QKF on DOP development via in vivo experiment. Methods. Network pharmacology was used to detect the key targets and signaling pathways of QKF on DOP. The effects of QKF on DOP were examined by the phenotypic characteristics, micro-CT, and hematoxylin-eosin (H&E) staining. The predicted targets and pathways were validated by a streptozocin- (STZ-) induced mouse model. Subsequently, the levels of the selected genes and proteins were analyzed using qRT-PCR and Western blot. Finally, AutoDock and PyMOL were used for molecular docking. Results. In this study, 90 active compounds and 2970 related disease targets have been found through network pharmacology. And QKF could improve the microstructures of femur bone mass, reduce inflammatory cell infiltration, and downregulate the levels of TNF-α, IKBKB, IL-6, and IL-1β. Moreover, the underlying effect of PI3K/Akt/NF-κB pathways was also recommended in the treatment. Conclusion. Altogether, our findings suggested that QKF could markedly alleviate osteoblast dysfunction by modulating the key targets and PI3K/Akt/NF-κB signaling pathway.

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Plant‐Derived Treatments for Different Types of Muscle Atrophy

Wang,

Tang,

Wang

et al. 2025

Phytotherapy Research

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With the development of medicine and chemistry, an increasing number of plant‐derived medicines have been shown to exert beneficial therapeutic on the treatment of various physical and psychological diseases. In particular, by using physical chemistry methods, we are able to examine the chemical components of plants and the effects of these substances on the human body. Muscle atrophy (MA) is characterized by decreased muscle mass and function, is caused by multiple factors and severely affects the quality of life of patients. The multifactorial and complex pathogenesis of MA hinders drug research and disease treatment. However, phytotherapy has achieved significant results in the treatment of MA. We searched PubMed and the Web of Science for articles related to plant‐derived substances and muscle atrophy. After applying exclusion and inclusion criteria, 166 and 79 articles met the inclusion criteria, respectively. A total of 173 articles were included in the study after excluding duplicates. The important role of phytoactives such as curcumin, resveratrol, and ginsenosides in the treatment of MA (e.g., maintaining a positive nitrogen balance in muscles and exerting anti‐inflammatory and antioxidant effects) has been extensively studied. Unfortunately, MA dose not have to a single cause, and each cause has its own unique mechanism of injury. This review focuses on the therapeutic mechanisms of active plant components in MA and provides insights into the personalized treatment of MA.

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Schisandrin C Affects Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells and Glucose Uptake in Skeletal Muscle Cells

Cited by 6 publications

References 38 publications

A Review of Extraction and Purification, Biological Properties, Structure–Activity Relationships and Future Prospects of Schisandrin C: A Major Active Constituent of Schisandra Chinensis

A Review of Extraction and Purification, Biological Properties, Structure–Activity Relationships and Future Prospects of Schisandrin C: A Major Active Constituent of Schisandra Chinensis

Qizhi Kebitong Formula Ameliorates Streptozocin‐Induced Diabetic Osteoporosis through Regulating the PI3K/Akt/NF‐κB Pathway

Plant‐Derived Treatments for Different Types of Muscle Atrophy

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