2018
DOI: 10.1016/j.archoralbio.2018.01.018
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Schisandrin C enhances odontoblastic differentiation through autophagy and mitochondrial biogenesis in human dental pulp cells

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Cited by 16 publications
(13 citation statements)
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“…Recently, it was demonstrated that resveratrol induced autophagy by directly inhibiting the mTOR-ULK1 pathway in human cells (Park et al, 2016). Moreover, previous studies have suggested that autophagy functions positively in odontoblastic differentiation (Takanche, Kim, Kim, Han, & Yi, 2018) and that autophagy maintains cellular homeostasis by improving pulpal mitochondrial activity (Y. H. Lee et al, 2015), while the present work further establishes a regulatory loop among resveratrol, autophagy, and the JNK signaling pathway in human DPSCs during TNFα-stimulated inflammatory responses.…”
Section: Discussionsupporting
confidence: 69%
“…Recently, it was demonstrated that resveratrol induced autophagy by directly inhibiting the mTOR-ULK1 pathway in human cells (Park et al, 2016). Moreover, previous studies have suggested that autophagy functions positively in odontoblastic differentiation (Takanche, Kim, Kim, Han, & Yi, 2018) and that autophagy maintains cellular homeostasis by improving pulpal mitochondrial activity (Y. H. Lee et al, 2015), while the present work further establishes a regulatory loop among resveratrol, autophagy, and the JNK signaling pathway in human DPSCs during TNFα-stimulated inflammatory responses.…”
Section: Discussionsupporting
confidence: 69%
“…The inducing effects of Schisandrin B on cell autophagy may contribute to its liver toxic effects [39]. Schisandrin C enhanced the regulation of autophagy to exert an anti-oxidative mechanism [40] or promote odontoblastic differentiation of human dental pulp cells [41]. For the conflicting roles of schisandrins on autophagy between different investigations, several reasons are considered, such as different cell types and drug treatment time.…”
Section: Discussionmentioning
confidence: 99%
“…Mineral trioxide aggregate (MTA) inhibits autophagy via Notch pathway to enhance proliferation and odontoblastic differentiation of DPCs 67 . Schisandrin C activates autophagy in hDPCs to enhances its odontoblastic differentiation 68 . Furthermore, resin monomers 2‐hydroxyethyl methacrylate (HEMA) and triethylene glycol dimethacrylate (TEGDMA), two cytotoxic chemicals released from dental materials, activate autophagy in hDPSCs and dental mesenchymal cells, 69‐71 which are respectively mediated by nuclear factor‐kB (NF‐kB), MEK/ERK and AMPK/mTOR signal pathways 69‐71 .…”
Section: Physiological Functions Of Autophagy In Toothmentioning
confidence: 99%
“…Induction of autophagy by resveratrol suppresses the secretion of interleukin‐6 (IL‐6) and interleukin‐8 (IL8) by TNF‐a‐treated DPSCs 89 . Activation of autophagy by natural compound Schisandrin C enhances odontoblastic differentiation of hDPCs 68 …”
Section: Therapeutic Implication Of Autophagy In Toothmentioning
confidence: 99%