Schistosoma japonicum infection modulates the development of allergen-induced airway inflammation in mice

Mo, Hongmei; Lei, Jiahui; Jiang, Ziwei; Wang, Cheng-zu; Cheng, Yue; Lü, Yonglong; Liu, Wenqi

doi:10.1007/s00436-008-1114-1

Cited by 41 publications

(35 citation statements)

References 33 publications

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“…Several species of helminthes including S . japonicum have been shown to down-modulate airway hyperresponsiveness in human and murine models [13–15]. The interaction between helminthes infection and airway inflammation is affected by various factors, such as infection phases, parasite loads and species of helminthes [16].…”

Section: Introductionmentioning

confidence: 99%

Schistosoma japonicum infection downregulates house dust mite-induced allergic airway inflammation in mice

Qiu¹,

Fan²,

Yang³

et al. 2017

PLoS ONE

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The “hygiene hypothesis” is a theory try to explain the dramatic increases in the prevalence of autoimmune and allergic diseases over the past two to three decades in developed countries. According to this theory, reduced exposure to parasites and microorganisms in childhood is the main cause for the increased incidences of both T helper 1 (Th1)-mediated autoimmunity and Th2-mediated allergy. In this study, we investigated the impact of Schistosoma japonicum infection on the allergic airway inflammation induced by repeated intracheal inoculations of house dust mites (HDM), which is a Th17 and neutrophils dominant murine asthma model, mimicking severe asthma. We found that S. japonicum infection downregulated airway hyperresponsiveness. The infiltrating cells, Th17 and Th2 effector cytokines in the bronchoalveolar lavage (BAL) fluids and lungs were significantly reduced in the infected mice. Our findings indicated that S. japonicum infection was able to effectively inhibit host’s allergic airway inflammation, which may be related to the upregulated Treg cells upon infection. To our knowledge, it is the first study to reveal the impact of S. japonicum infection on house dust mite induced severe asthma. More in depth investigation is need to elucidate the underlying mechanisms.

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Section: Introductionmentioning

confidence: 99%

Schistosoma japonicum infection downregulates house dust mite-induced allergic airway inflammation in mice

Qiu¹,

Fan²,

Yang³

et al. 2017

PLoS ONE

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“…Apart from S. pneumoniae, other infectious agents such as helminths, lactobacilli, and Mycobacterium have been shown to induce Tregs and suppress AAD in mouse models (35)(36)(37). Mycobacterial cell wall components (lipoglycans lipoarabinomannan, and phosphatidylinositol mannan) also have been shown to suppress AAD; however, their effects on AHR have not been determined (38).…”

Section: Discussionmentioning

confidence: 99%

Components of Streptococcus pneumoniae Suppress Allergic Airways Disease and NKT Cells by Inducing Regulatory T Cells

Thorburn

Foster

Gibson

et al. 2012

The Journal of Immunology

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Asthma is an allergic airways disease (AAD) caused by dysregulated immune responses and characterized by eosinophilic inflammation, mucus hypersecretion, and airway hyperresponsiveness (AHR). NKT cells have been shown to contribute to AHR in some mouse models. Conversely, regulatory T cells (Tregs) control aberrant immune responses and maintain homeostasis. Recent evidence suggests that Streptococcus pneumoniae induces Tregs that have potential to be harnessed therapeutically for asthma. In this study, mouse models of AAD were used to identify the S. pneumoniae components that have suppressive properties, and the mechanisms underlying suppression were investigated. We tested the suppressive capacity of type-3-polysaccharide (T3P), isolated cell walls, pneumolysoid (Ply) and CpG. When coadministered, T3P + Ply suppressed the development of: eosinophilic inflammation, Th2 cytokine release, mucus hypersecretion, and AHR. Importantly, T3P + Ply also attenuated features of AAD when administered during established disease. We show that NKT cells contributed to the development of AAD and also were suppressed by T3P + Ply treatment. Furthermore, adoptive transfer of NKT cells induced AHR, which also could be reversed by T3P + Ply. T3P + Ply-induced Tregs were essential for the suppression of NKT cells and AAD, which was demonstrated by Treg depletion. Collectively, our results show that the S. pneumoniae components T3P + Ply suppress AAD through the induction of Tregs that blocked the activity of NKT cells. These data suggest that S. pneumoniae components may have potential as a therapeutic strategy for the suppression of allergic asthma through the induction of Tregs and suppression of NKT cells.

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“…Thus, a number of groups have hypothesized that Schistosoma egg antigens can induce production of CD4 ϩ CD25 ϩ regulatory T cells, downmodulating Th2 allergic airway inflammation and inhibiting asthma development. Indeed, this appears to be the case in experiments with murine models, which have revealed novel aspects of protection against asthma and suggest a mechanistic explanation for the protective effect of schistosome infection on its development and other allergic responses as well (87,145,150,222).…”

Section: Allergy Autoimmune Disease and Schistosome Infectionmentioning

confidence: 94%

Schistosomiasis in the People's Republic of China: the Era of the Three Gorges Dam

et al. 2010

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SUMMARY The potential impact of the Three Gorges Dam (TGD) on schistosomiasis transmission in China has invoked considerable global concern. The TGD will result in changes in the water level and silt deposition downstream, favoring the reproduction of Oncomelania snails. Combined with blockages of the Yangtze River's tributaries, these changes will increase the schistosomiasis transmission season within the marshlands along the middle and lower reaches of the Yangtze River. The changing schistosome transmission dynamics necessitate a comprehensive strategy to control schistosomiasis. This review discusses aspects of the epidemiology and transmission of Schistosoma japonicum in China and considers the pathology, clinical outcomes, diagnosis, treatment, immunobiology, and genetics of schistosomiasis japonica together with an overview of current progress in vaccine development, all of which will have an impact on future control efforts. The use of synchronous praziquantel (PZQ) chemotherapy for humans and domestic animals is only temporarily effective, as schistosome reinfection occurs rapidly. Drug delivery requires a substantial infrastructure to regularly cover all parts of an area of endemicity. This makes chemotherapy expensive and, as compliance is often low, a less than satisfactory control option. There is increasing disquiet about the possibility that PZQ-resistant schistosomes will develop. Consequently, as mathematical modeling predicts, vaccine strategies represent an essential component in the future control of schistosomiasis in China. With the inclusion of focal mollusciciding, improvements in sanitation, and health education into the control scenario, China's target of reducing the level of schistosome infection to less than 1% by 2015 may be achievable.

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Schistosoma japonicum infection modulates the development of allergen-induced airway inflammation in mice

Cited by 41 publications

References 33 publications

Schistosoma japonicum infection downregulates house dust mite-induced allergic airway inflammation in mice

Schistosoma japonicum infection downregulates house dust mite-induced allergic airway inflammation in mice

Components of Streptococcus pneumoniae Suppress Allergic Airways Disease and NKT Cells by Inducing Regulatory T Cells

Schistosomiasis in the People's Republic of China: the Era of the Three Gorges Dam

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