Schistosoma mansoni: Cholesteryl ester profiles of plasma and liver in experimentally infected mice

Oliveira, Dalmo N.G. de; Costa, JoséCarlos de M.

doi:10.1016/0014-4894(77)90029-7

Cited by 6 publications

(2 citation statements)

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“…Forty-three of these studies reported on total cholesterol [6][7][8][13][14][15][16][17]. Of these, 28 reported on participants infected with Schistosoma species or with mixed helminths that included Schistosoma species [6,7,13,15,[25][26][27][28]30,31,35,37,[39][40][41][42][43][44]46,[48][49][50][51][52][53][54][55]. These 28 studies mostly reported that infected individuals or those challenged with helminth products had lower total cholesterol than uninfected participants.…”

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

“…These 28 studies mostly reported that infected individuals or those challenged with helminth products had lower total cholesterol than uninfected participants. Including all helminths in other studies, 96% (24 of 25 total studies, which consisted of 11 human and 13 animal studies with 1 mixed study) that reported a relationship between helminth infection and lower total cholesterol found this inverse association to be significant [13,17,[24][25][26][27][28][29][30][31]33,35,[38][39][40][41]44,[46][47][48][49][50][51]54,55]. In contrast, 6 studies (14%, all with different helminths with 4 human and 2 animal studies) reported associations with increased total cholesterol [6,20,21,33,34,36], and 13 (30%, 10 human and 3 animal studies, of which 6 examined schistosome infections) demonstrated no effect of infection on total cholesterol [7,8,[14][15][16]22,23,32,36,37,42,43,53].…”

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

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Effects of helminths and anthelmintic treatment on cardiometabolic diseases and risk factors: A systematic review

et al. 2023

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Background Globally, helminth infections and cardiometabolic diseases often overlap in populations and individuals. Neither the causal relationship between helminth infections and cardiometabolic diseases nor the effect of helminth eradication on cardiometabolic risk have been reviewed systematically in a large number of human and animal studies. Methods We conducted a systematic review assessing the reported effects of helminth infections and anthelmintic treatment on the development and/or severity of cardiometabolic diseases and risk factors. The search was limited to the most prevalent human helminths worldwide. This study followed PRISMA guidelines and was registered prospectively in PROSPERO (CRD42021228610). Searches were performed on December 10, 2020 and rerun on March 2, 2022 using Ovid MEDLINE ALL (1946 to March 2, 2022), Web of Science, Cochrane Library, Global Index Medicus, and Ovid Embase (1974 to March 2, 2022). Randomized clinical trials, cohort, cross-sectional, case-control, and animal studies were included. Two reviewers performed screening independently. Results Eighty-four animal and human studies were included in the final analysis. Most studies reported on lipids (45), metabolic syndrome (38), and diabetes (30), with fewer on blood pressure (18), atherosclerotic cardiovascular disease (11), high-sensitivity C-reactive protein (hsCRP, 5), and non-atherosclerotic cardiovascular disease (4). Fifteen different helminth infections were represented. On average, helminth-infected participants had less dyslipidemia, metabolic syndrome, diabetes, and atherosclerotic cardiovascular disease. Eleven studies examined anthelmintic treatment, of which 9 (82%) reported post-treatment increases in dyslipidemia, metabolic syndrome, and diabetes or glucose levels. Results from animal and human studies were generally consistent. No consistent effects of helminth infections on blood pressure, hsCRP, or cardiac function were reported except some trends towards association of schistosome infection with lower blood pressure. The vast majority of evidence linking helminth infections to lower cardiometabolic diseases was reported in those with schistosome infections. Conclusions Helminth infections may offer protection against dyslipidemia, metabolic syndrome, diabetes, and atherosclerotic cardiovascular disease. This protection may lessen after anthelmintic treatment. Our findings highlight the need for mechanistic trials to determine the pathways linking helminth infections with cardiometabolic diseases. Such studies could have implications for helminth eradication campaigns and could generate new strategies to address the global challenge of cardiometabolic diseases.

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