Schistosoma mansoni: Neurotransmitters and the mobility of cercariae and schistosomules

Ercoli, N.; Payares, Gilberto; Nunez, Deyanira

doi:10.1016/0014-4894(85)90074-8

Cited by 25 publications

(15 citation statements)

References 22 publications

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“…HA is variably distributed among parasitic flatworms [74][75][76][77][78] but is also implicated in the control of muscle function and movement [31]. Some species are capable of endogenous biosynthesis of HA and have high tissue levels of the amine [79][80][81], whereas in other species, HA is present at low levels and may be entirely of host origin [82].…”

Section: Discussionmentioning

confidence: 99%

Histamine Immunoreactive Elements in the Central and Peripheral Nervous Systems of the Snail, Biomphalaria spp., Intermediate Host for Schistosoma mansoni

et al. 2015

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Histamine appears to be an important transmitter throughout the Animal Kingdom. Gastropods, in particular, have been used in numerous studies establishing potential roles for this biogenic amine in the nervous system and showing its involvement in the generation of diverse behaviours. And yet, the distribution of histamine has only previously been described in a small number of molluscan species. The present study examined the localization of histamine-like immunoreactivity in the central and peripheral nervous systems of pulmonate snails of the genus Biomphalaria. This investigation demonstrates immunoreactive cells throughout the buccal, cerebral, pedal, left parietal and visceral ganglia, indicative of diverse regulatory functions in Biomphalaria. Immunoreactivity was also present in statocyst hair cells, supporting a role for histamine in graviception. In the periphery, dense innervation by immunoreactive fibers was observed in the anterior foot, perioral zone, and other regions of the body wall. This study thus shows that histamine is an abundant transmitter in these snails and its distribution suggest involvement in numerous neural circuits. In addition to providing novel subjects for comparative studies of histaminegic neurons in gastropods, Biomphalaria is also the major intermediate host for the digenetic trematode parasite, which causes human schistosomiasis. The study therefore provides a foundation for understanding potential roles for histamine in interactions between the snail hosts and their trematode parasites.

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Section: Discussionmentioning

confidence: 99%

Histamine Immunoreactive Elements in the Central and Peripheral Nervous Systems of the Snail, Biomphalaria spp., Intermediate Host for Schistosoma mansoni

et al. 2015

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“…Exogenously added histamines are known to increase the neuromuscular activity of schistosomes (40) possibly by binding to a 65-kDa G protein-coupled histamine receptor expressed on the surface of S. mansoni (41). Because SmTCTP can induce release of histamine, the above findings might suggest an important physiological function for SmTCTP in the regulation of motor activity of the worm.…”

Section: Fig 4 Expression Of Smtctp In Various Life Cycle Stages Of Smentioning

confidence: 96%

Cloning and Characterization of a Calcium-binding, Histamine-releasing Protein from Schistosoma mansoni

Rao¹,

Chen

Munirathinam

et al. 2002

Journal of Biological Chemistry

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A homologue of the mammalian translationally controlled tumor protein (TCTP) was cloned from the human parasite Schistosoma mansoni (SmTCTP). Sequence analysis showed that SmTCTP differed from other reported TCTPs in having only one signature sequence. Subsequently, SmTCTP was cloned in a T7 expression system and expressed as a histidine-tagged fusion protein. Recombinant SmTCTP (rSmTCTP) has a molecular mass of ϳ23 kDa with the histidine tag. Further analysis showed that SmTCTP transcripts and protein are expressed in all life cycle stages of the parasite within the vertebrate hosts. Interestingly, antibodies to SmTCTP were present in the sera of mice 9 weeks after infection with S. mansoni. Characterization studies showed that rSmTCTP is a calcium-binding protein that can cause histamine release from basophil/mast cells and induce eosinophil infiltration. These findings suggest that SmTCTP may have an important role in the development of allergic inflammatory responses associated with schistosomiasis and may be a target for new drug development.

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“…The observed cercaricidal effect of Safe Sea on T. szidati cercariae may, at least in part, be related to the H1-antihistamine diphenhydramine contained in the product. H1-antihistamines seem to interfere with cercarial histaminergic mechanisms, leading to a complete immobilisation and death (Ercoli et al 1985).…”

Section: Discussionmentioning

confidence: 99%

Cream formulations protecting against cercarial dermatitis by Trichobilharzia

2007

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Dermatitis caused by penetrating bird schistosome cercariae is an emerging global public health problem. Infections may be prevented by the use of topical formulations that inhibit cercarial skin penetration. We evaluated nine water resistant formulations by exposing treated arms of volunteers to Trichobilharzia szidati cercariae. Six formulations protected from cercarial invasion. However, after immersion of the treated skin in water (2 x 20 min), only two formulations offered full protection: (1) Safe Sea, a cream protecting against jelly fish, (2) niclosamide in water resistant sun protecting cream formulations at concentrations as low as 0.05%. In an in vitro system Safe Sea and a 0.1% niclosamide formulation caused a high damage rate in T. szidati (92% and 99% after 5 min; only niclosamide with lethal effect) but not in Schistosoma mansoni (1% and 72%; both formulations with lethal effect). However, a 1% niclosamide formulation damaged S. mansoni sufficiently (100% after 5 min) and might offer full penetration protection.

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Schistosoma mansoni: Neurotransmitters and the mobility of cercariae and schistosomules

Cited by 25 publications

References 22 publications

Histamine Immunoreactive Elements in the Central and Peripheral Nervous Systems of the Snail, Biomphalaria spp., Intermediate Host for Schistosoma mansoni

Histamine Immunoreactive Elements in the Central and Peripheral Nervous Systems of the Snail, Biomphalaria spp., Intermediate Host for Schistosoma mansoni

Cloning and Characterization of a Calcium-binding, Histamine-releasing Protein from Schistosoma mansoni

Cream formulations protecting against cercarial dermatitis by Trichobilharzia

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