Schistosomiasis in International Refugees and Migrant Populations

Adeel, Ahmed Awad

doi:10.1007/s40475-017-0128-0

Cited by 1 publication

(1 citation statement)

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“…Approximately 85% of these infections occur in sub-Sahara Africa 3,4 . Movement of refugees and mass migration of individuals from endemic to non-endemic areas have recently expanded the areas at risk of schistosomiasis and increased disease prevalence in recent times [5][6][7] . Around 200,000 people die from Schistosoma infections each year and many more suffer with serious disabilities.…”

Section: Introductionmentioning

confidence: 99%

Structural, functional and docking analysis against Schistosoma mansoni dihydroorotate dehydrogenase for potential chemotherapeutic drugs

Otarigho

2019

F1000Res

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Background: Praziquantel, as the only drug for the treatment of schistosomiasis, is under serious threat due to the emergence of resistant strains of Schistosoma species. There is an urgent need to search for alternative chemotherapy to supplement or complement praziquantel. Schistosoma dihydroorotate dehydrogenase (DHODH) has been recommended as a druggable target for schistosomiasis chemotherapy. The development of novel molecular modeling approaches, alongside with computational tools and rapid sequencing of pathogen genomes, have facilitated drug discovery. Therefore, the aim of this study was to employ computational approaches to screen compounds against Schistosoma mansoni DHODH. Methods: In this study, DHODH was used to blast on the latest version of DrugBank that contained 12,110 compounds, resulting in 26 drugs that can bind. Results: In silico docking shows that 13 drugs can bind strongly with an estimated free energy of binding, total intermolecular energy and estimated inhibition constant (Ki) greater than or equal to -8.6 kcal/mol, -8.12 kcal/mol and 1.12 µM, respectively. These compounds include the approved drugs manitimus, capecitabine, brequinar analog and leflunomide. Conclusions: These results indicate that these drugs have the potential for use in the control of schistosomiasis in the future.

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Section: Introductionmentioning

confidence: 99%

Structural, functional and docking analysis against Schistosoma mansoni dihydroorotate dehydrogenase for potential chemotherapeutic drugs

Otarigho

2019

F1000Res

View full text Add to dashboard Cite

show abstract

Schistosomiasis in International Refugees and Migrant Populations

Cited by 1 publication

References 54 publications

Structural, functional and docking analysis against Schistosoma mansoni dihydroorotate dehydrogenase for potential chemotherapeutic drugs

Structural, functional and docking analysis against Schistosoma mansoni dihydroorotate dehydrogenase for potential chemotherapeutic drugs

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