Schizencephaly on fetal MRI

Reddy, Sai Nidhi G; Rudakemwa, Emmanuel; Modi, Mitul

doi:10.4102/sajr.v12i3.562

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“…There are limited reports of fetal schizencephaly using iuMR imaging—for example, small case series [ 16 ] and case reports [ 17 – 19 ] with the largest case series to date by Nabavizadeh et al [ 20 ] who reported 10 fetuses with schizencephaly on iuMR imaging and confirmed on post-natal imaging including eight bilateral cases. One interesting finding in that study was a morphological change in the type of cleft between the pre-natal and post-natal imaging as 47% of the ‘open-lip’ schizencephalies detected in utero had become ‘closed lip’ on post-natal imaging.…”

Section: Discussionmentioning

confidence: 99%

Schizencephaly revisited

Griffiths

2018

Neuroradiology

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PurposeIn this paper, I will report the range of appearances of schizencephaly in children and fetuses by reviewing a 10-year experience from a single centre and detail classification systems for the different forms of schizencephaly. This will lead to re-assessment of possible aetiological and mechanistic causes of schizencephaly.MethodsAll cases of pediatric and fetal schizencephaly were located on the local database between 2007 and 2016 inclusive. The studies were reviewed for the presence, location and type of schizencephaly, as well as the state of the (cavum) septum pellucidum, the location of the fornices and the presence of other brain abnormalities.ResultsThe review included 21 children and 11 fetuses with schizencephaly. Schizencephaly (type 1) was found in 9% of children but no fetuses, schizencephaly (type 2) was present in 67% of the pediatric cases and in 45% of fetuses, whilst schizencephaly (type 3) was present in approximately 24% of children and 55% of fetuses. Other brain abnormalities were found in 67% of children and 55% of fetuses.ConclusionI have proposed a new system for classifying schizencephaly that takes into account all definitions of the abnormality in the literature. Using that approach, I have described the appearances and associations of pediatric and fetal cases of schizencephaly from a single centre. Review of the current literature appears to favour an acquired destructive aetiology for most cases of schizencephaly, and I have proposed a mechanism to explain the cortical formation abnormalities found consistently in and around areas of schizencephaly.

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Section: Discussionmentioning

confidence: 99%

Schizencephaly revisited

Griffiths

2018

Neuroradiology

View full text Add to dashboard Cite

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Schizencephaly on fetal MRI

Cited by 1 publication

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Schizencephaly revisited

Schizencephaly revisited

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