Schizophrenia: A New Approach. II. Result of a Year's Research

Hoffer, A.; Osmond, Humphry; Smythies, J. R.

doi:10.1192/bjp.100.418.29

Cited by 290 publications

(51 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is a growing number of studies on this topic, since toxic radicals are suggested to play a role in the etiology of schizophrenia [17]. The increase in oxidative stress index (OSI) in patients with schizophrenia may play a significant role in pathophysiological disease mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Oxidative metabolism may be associated with negative symptoms in schizophrenia

Güneş

Altındağ

Bulut

et al. 2017

Psychiatry and Clinical Psychopharmacology

View full text Add to dashboard Cite

Objective: In the present study, we aimed to examine the relationship between the oxidative metabolism with disease severity, sociodemographic, and clinical characteristics in the patients with schizophrenia. Methods: Seventy-one patients with schizophrenia and 76 healthy volunteers were included in the study. Plasma total antioxidant level (TAL) and total oxidant level (TOL) were analyzed, and oxidative stress index (OSI) was calculated.Results: There was a statistically significant increase in TOL and OSI and decrease in TAL in the patients with schizophrenia compared to the controls (p < .05). There were positive, mild, statistically significant correlations between TOL, OSI, and Positive and Negative Syndrome Scale-Total scores (p = .01, p = .01, respectively), Positive and Negative Syndrome ScaleNegative scores (p = .002, p = .001, respectively), Positive and Negative Syndrome Scale Global Psychopathology scores (p = .03, p = .03, respectively), and Clinical Global ImpressionSeverity Scale scores (p = .008, p = .009 respectively). OSI levels were significantly lower in the patients who were on treatment with atypical antipsychotics (AAP) compared to the patients who were on typical antipsychotics (TAP) and combined antipsychotic (CAP) agents (p = .032). Conclusions: Oxidative stress was higher in schizophrenia patients. The increased severity of negative symptoms was in line with the disruption in oxidative balance. Oxidative stress is quite lower in AAP users compared to the TAP and CAP users. One of the mechanisms underlying the fact that AAPs are more effective on negative symptoms than typical agents may be the positive effect on the oxidative stress.ARTICLE HISTORY

show abstract

Section: Introductionmentioning

confidence: 99%

Oxidative metabolism may be associated with negative symptoms in schizophrenia

Güneş

Altındağ

Bulut

et al. 2017

Psychiatry and Clinical Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…Osmond and Smythies suggested that schizophrenia is the result of a metabolic aberration of the catecho1amines (17). Hoffer suggested that oxidized derivatives of epinephrine were causal factors ( 11). Harley Mason suggested that 3-4 dimethoxypheny1ethylamine (DMPEA) caused psychopathological disturbances (10).…”

Section: Discussionmentioning

confidence: 99%

Psychiatric Manifestations of Levodopa

Yaryura-Tobias

Diamond

Merlis

1972

Canadian Psychiatric Association Journal

View full text Add to dashboard Cite

“…Antagonism 190,194,197 These eompounds included ergot hallucinogens, adrenoehrome and adrenolution, harmine, tryptamine, ibogaine, mitrogynine, dimethyl-and diethyltryptamine, and psiloeybin.…”

Section: How Does Lsd Oct?mentioning

confidence: 99%

D‐Lysergic acid diethylamide (LSD): A review of its present status

Hoffer

1965

Clin Pharma and Therapeutics

View full text Add to dashboard Cite

This is a review of an important but controversial subject, written by one of the important figures involved in the controversy. It was not possible to get a review in depth by someone who was not also involved in the controversy. With this in mind, this review was accepted for publication because it was written by an authority actively engaged in the problem and because it was thought important to bring details of the subject to the attention of a large readership. Correspondence is invited.

show abstract

Schizophrenia: A New Approach. II. Result of a Year's Research

Cited by 290 publications

References 8 publications

Oxidative metabolism may be associated with negative symptoms in schizophrenia

Oxidative metabolism may be associated with negative symptoms in schizophrenia

Psychiatric Manifestations of Levodopa

D‐Lysergic acid diethylamide (LSD): A review of its present status

Contact Info

Product

Resources

About