2019
DOI: 10.3389/fpsyt.2019.00270
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Schizophrenia and Hereditary Polyneuropathy: PMP22 Deletion as a Common Pathophysiological Link?

Abstract: Background: Schizophrenic disorders are common and debilitating due to their symptoms, which can include delusions, hallucinations, and other negative symptoms. Organic forms can result from various cerebral disorders. In this paper, we discuss a potential association between schizophrenia and hereditary polyneuropathies (PNPs). Case presentation: We present the case of a 55-year-old female patient with chronically paranoid–hallucinatory schizophrenia, severe cognitive defici… Show more

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Cited by 2 publications
(1 citation statement)
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“…We indeed found moderate upregulation of Rxrβ, Apoc2, Abca1, and Pmp22 in SZ dlPFC gray matter as compared to controls. Interestingly, LXR signaling is involved in the development of ventral midbrain dopaminergic neurons 52,58 and there is a genetic association between PMP22 and SZ 59 . In vitro studies have shown contradictory effects of antipsychotics on LXR signaling in that one study has reported an increased mRNA expression of Abca1 and Apoe 60 , whereas a second study has shown that antipsychotics reduce cholesterol synthesis and export from the endoplasmic reticulum, and do not induce LXR activation 61 .…”
Section: Discussionmentioning
confidence: 99%
“…We indeed found moderate upregulation of Rxrβ, Apoc2, Abca1, and Pmp22 in SZ dlPFC gray matter as compared to controls. Interestingly, LXR signaling is involved in the development of ventral midbrain dopaminergic neurons 52,58 and there is a genetic association between PMP22 and SZ 59 . In vitro studies have shown contradictory effects of antipsychotics on LXR signaling in that one study has reported an increased mRNA expression of Abca1 and Apoe 60 , whereas a second study has shown that antipsychotics reduce cholesterol synthesis and export from the endoplasmic reticulum, and do not induce LXR activation 61 .…”
Section: Discussionmentioning
confidence: 99%