Schizophrenia and Other Psychotic Disorders in a Cohort of Sexually Abused Children

Cutajar, Margaret; Mullen, Paul E.; Ogloff, James R. P.; Thomas, Stuart; Wells, David; Spataro, Josie

doi:10.1001/archgenpsychiatry.2010.147

Cited by 178 publications

(147 citation statements)

References 32 publications

(27 reference statements)

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“…Repeated exposure to severe stress in critical developmental stages, especially during the early childhood, may disrupt PFC development and impair working memory later in life (Evans and Schamberg, 2009;Hanson et al, 2012). Accumulating evidence demonstrates that early-life stress is one of the major risk factors for psychiatric disorders, including schizophrenia, depression, and anxiety disorders (Bradley et al, 2008;Cutajar et al, 2010;Nugent et al, 2011) that are associated with prefrontal dysfunction (Goto et al, 2010) and structural abnormalities (Black et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Stress during a Critical Postnatal Period Induces Region-Specific Structural Abnormalities and Dysfunction of the Prefrontal Cortex via CRF1

Yang

Liao

Uribe-Mariño

et al. 2014

Neuropsychopharmacol

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During the early postnatal period, environmental influences play a pivotal role in shaping the development of the neocortex, including the prefrontal cortex (PFC) that is crucial for working memory and goal-directed actions. Exposure to stressful experiences during this critical period may disrupt the development of PFC pyramidal neurons and impair the wiring and function of related neural circuits. However, the molecular mechanisms of the impact of early-life stress on PFC development and function are not well understood. In this study, we found that repeated stress exposure during the first postnatal week hampered dendritic development in layers II/III and V pyramidal neurons in the dorsal agranular cingulate cortex (ACd) and prelimbic cortex (PL) of neonatal mice. The deleterious effects of early postnatal stress on structural plasticity persisted to adulthood only in ACd layer V pyramidal neurons. Most importantly, concurrent blockade of corticotropin-releasing factor receptor 1 (CRF 1 ) by systemic antalarmin administration (20 mg/g of body weight) during early-life stress exposure prevented stress-induced apical dendritic retraction and spine loss in ACd layer V neurons and impairments in PFC-dependent cognitive tasks. Moreover, the magnitude of dendritic regression, especially the shrinkage of apical branches, of ACd layer V neurons predicted the degree of cognitive deficits in stressed mice. Our data highlight the region-specific effects of early postnatal stress on the structural plasticity of prefrontal pyramidal neurons, and suggest a critical role of CRF 1 in modulating early-life stress-induced prefrontal abnormalities.

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Section: Introductionmentioning

confidence: 99%

Stress during a Critical Postnatal Period Induces Region-Specific Structural Abnormalities and Dysfunction of the Prefrontal Cortex via CRF1

Yang

Liao

Uribe-Mariño

et al. 2014

Neuropsychopharmacol

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show abstract

“…There is a robust research foundation that has demonstrated a relationship between adverse childhood experience (poverty, neglect, maltreatment, physical, sexual, and psychological abuse) and development of an array of mental disorders (Beardslee, Chien, and Bell 2011;Fitzsimons et al 2016;Tillfors et al 2009;Hoeve et al 2015;Kelleher et al 2013;Cutajar et al 2010;Kelleher et al 2013;DaruyFilho et al 2011). It is abundantly clear that such social pathologies are good for no one's mental health.…”

Section: Anxiety and The Role Of Resiliencementioning

confidence: 99%

Global Mental Health and Adolescent Anxiety: Kin, Care and Struggle in New Mexico

Jenkins

Stone

2017

Cult Med Psychiatry

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While recent developments within the field of global mental health have illuminated the reality of serious mental health difficulties worldwide, particularly in low-income settings, research that focuses on children and adolescents remains underdeveloped. This is especially the case with respect to ethnographic studies of lived experience of adolescents diagnosed with serious mental health conditions. Drawing from an interdisciplinary study of adolescents in New Mexico who were afflicted with a broad range of disorders according to contemporary research diagnostic criteria, this article focuses on anxiety-related conditions with respect to subjective experience and social-ecological contexts of living with such conditions. We offer preliminary observations regarding the value of linking ethnographic and research diagnostic data to address questions of resilience, endurance, capacity and struggle. These observations are intended as the basis for the formulation of more precise hypotheses about adolescent anxiety, kin, and care under conditions of structural violence marked by psychological, residential, and intergenerational adversity.

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“…these factors may predict shifts upwards the psychosis continuum along the full spectrum. Many studies have shown the role of (psychological, physical and sexual) trauma during childhood and adolescence in the development of psychosis and psychotic symptoms/experiences (Arseneault et al, 2011;Cutajar et al, 2010;Fisher et al, 2010;Introduction 2004b;Verdoux, Sorbara et al, 2002), urbanicity (Spauwen, Krabbendam, Lieb, Wittchen, & van Os, 2004;Spauwen et al, 2006a;Stefanis, Delespaul, Smyrnis et al, 2004) and ethnic minority status . Recently, the concept of 'social defeat' has been introduced.…”

Section: Environmental Factorsmentioning

confidence: 99%

“…For example, one study reported the strongest associations for exposure before the age of 12 years (Fisher et al, 2010), others for exposure after age 12 years (Cutajar et al, 2010) and yet others did not find evidence for effect modification by age (Arseneault et al, 2011;Spauwen et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…One of the most extensively studied environmental factors in this context is developmental trauma (Read et al, 2005). Early trauma has been associated with a later diagnosis of schizophrenia (or other psychotic disorder) (Cutajar et al, 2010;Lardinois et al, 2011;Fisher et al, 2006) as well as with subthreshold psychotic experiences (Arseneault et al, 2011;Lataster et al, 2006;de Loore et al, 2007;Schreier et al, 2009). Early trauma has also been associated with developmental dynamic patterns, particularly in terms of abnormal persistence, of psychotic experiences over time (Spauwen et al, 2006;Cougnard et al, 2007;Wigman et al, 2011c and2011d).…”

Section: Introductionmentioning

confidence: 99%

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14:15 Persistence of the Extended Psychosis Phenotype in Young People: Link Between Vulnerability and Clinical Need

Wigman¹,

Vollebergh²,

Yung³

et al. 2012

Schizophrenia Research

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Schizophrenia and Other Psychotic Disorders in a Cohort of Sexually Abused Children

Cited by 178 publications

References 32 publications

Stress during a Critical Postnatal Period Induces Region-Specific Structural Abnormalities and Dysfunction of the Prefrontal Cortex via CRF1

Stress during a Critical Postnatal Period Induces Region-Specific Structural Abnormalities and Dysfunction of the Prefrontal Cortex via CRF1

Global Mental Health and Adolescent Anxiety: Kin, Care and Struggle in New Mexico

14:15 Persistence of the Extended Psychosis Phenotype in Young People: Link Between Vulnerability and Clinical Need

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