Schizophrenia and Sudden Death

Chute, Dennis J.; Grove, Christopher; Rajasekhara, Balu; Smialek, John E.

doi:10.1097/00000433-199906000-00005

Cited by 27 publications

(4 citation statements)

References 15 publications

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“…The cause for the apparent association is unclear: a proposed link to psychotropic medication is not without controversy, but recent publication indicates increased risk of sudden death in users of typical and atypical antipsychotic drugs [441][442][443]. In the obscure autopsy the neuroleptic malignant syndrome should be considered [444][445][446]: muscle changes may be present and there may be myoglobin in the renal tubules [447].…”

Section: Psychiatric Illness and Sudden Deathmentioning

confidence: 99%

Sudden adult death

Langlois

2009

Forensic Sci Med Pathol

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In the investigation of sudden death in adults, channelopathies, such as long QT syndrome, have risen to the fore in the minds of forensic pathologists in recent years. Examples of these disorders are touched upon in this review as an absence of abnormal findings at postmortem examination is characteristic and the importance of considering the diagnosis lies in the heritable nature of these conditions. Typically, a diagnosis of a possible channelopathy is evoked as an explanation for a 'negative autopsy' in a case of apparent sudden natural death. However, the one potential adverse effect of this approach is that subtle causes of sudden death may be overlooked. The intention of this article is to review and discuss potential causes of sudden adult death (mostly natural) that should be considered before resorting to a diagnosis of possible channelopathy. Nonetheless, it becomes apparent that many of the potential causes of sudden death can have a genetic basis. Thus, it becomes an important consideration that there may be a genetic basis to sudden death that extends beyond the negative autopsy.

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Section: Psychiatric Illness and Sudden Deathmentioning

confidence: 99%

Sudden adult death

Langlois

2009

Forensic Sci Med Pathol

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“…Retrospective , 2000). Retrospective studies conclude that cardiovascular mor-studies conclude that cardiovascular mortality tality in psychiatric patients is higher than in psychiatric patients is higher than in in the general population, especially in the general population, especially in patients patients with schizophrenia treated with with schizophrenia treated with antipsychotic drugs (Ruschena antipsychotic drugs (Ruschena et al et al, 1998;, 1998; Chute Chute et al et al, 1999). Disturbances of electri-, 1999).…”

Section: Declaration Of Interestmentioning

confidence: 99%

“…In general, psychotic systems (Lader, 1999). In general, psychotic disorders are related to higher rates of death, disorders are related to higher rates of death, not all of which can be related causally to not all of which can be related causally to medications, including suicide (Chute medications, including suicide (Chute et et al al, 1999). Antipsychotic medications have , 1999).…”

Section: Antipsychotic Medication Antipsychotic Medication and Suddenmentioning

confidence: 99%

“…Controversy continues of sudden death. Controversy continues to surround the issue of sudden death in to surround the issue of sudden death in patients with schizophrenia (Anon., patients with schizophrenia (Anon., 1966(Anon., ), 1966, although numerous reports of sudden although numerous reports of sudden deaths deaths of patients on antipsychotic medication ex-of patients on antipsychotic medication exist and many authors relate the phenome-ist and many authors relate the phenomenon to medications (Ruschena non to medications (Ruschena et al et al, 1998;, 1998; Chute Chute et al et al, 1999). , 1999).…”

Section: Antipsychotic Medication Antipsychotic Medication and Suddenmentioning

confidence: 99%

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