2016
DOI: 10.1186/s13034-016-0092-9
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Schizophrenia clinical symptom differences in women vs. men with and without a history of childhood physical abuse

Abstract: BackgroundChildhood abuse has been implicated as an environmental factor that increases the risk for developing schizophrenia. A recent large population-based case–control study found that abuse may be a risk factor for schizophrenia in women, but not men. Given the sex differences in onset and clinical course of schizophrenia, we hypothesized that childhood abuse may cause phenotypic differences in the disorder between men and women.MethodsWe examined the prevalence of childhood physical abuse in a cohort of … Show more

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Cited by 41 publications
(31 citation statements)
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“…In four additional studies, no associations between CT and cognitive function were observed (Green et al, 2014; Lysaker et al, 2002; Kelly et al, 2016; Ruby et al, 2017). In one study by van Os et al (2017), separate within-group analyses in patients and healthy participants identified a relationship between higher rates of CT and reduced general cognitive ability in healthy participants only but not in patients with schizophrenia (van Os et al, 2017).…”
Section: Resultsmentioning
confidence: 90%
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“…In four additional studies, no associations between CT and cognitive function were observed (Green et al, 2014; Lysaker et al, 2002; Kelly et al, 2016; Ruby et al, 2017). In one study by van Os et al (2017), separate within-group analyses in patients and healthy participants identified a relationship between higher rates of CT and reduced general cognitive ability in healthy participants only but not in patients with schizophrenia (van Os et al, 2017).…”
Section: Resultsmentioning
confidence: 90%
“…Five studies reported total severity scores, which were based on the RFQ (Poletti et al, 2017), the CAQ (Green et al, 2014), the CTQ (Marshall et al, 2016; Mansueto et al, 2017), and information retrieved from medical charts and non-standardized interviews (Schenkel et al, 2005). Thirteen studies used a composite score of severity and frequency and used dichotomous variables of CT exposure of (1) low versus high levels (Poletti et al, 2017; Aas et al, 2012b; Shannon et al, 2011; Mansueto et al, 2017), (2) absent versus high levels (Bucker et al, 2013; Kelly et al, 2016), (3) absent versus existent levels (van Os et al, 2017; Green et al, 2014; Green et al, 2015; McCabe et al, 2012; Schenkel et al, 2005) or (iv) below versus above the median split (Aas et al, 2012b) for the subscales or total scores. However not all studies reported mean group-level data for these measures.…”
Section: Resultsmentioning
confidence: 99%
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“…(2015) found that patients suffering from schizophrenia with increased awareness and concomitant increased distress were more likely to have experienced abuse as children. A study by Kelly et. al.…”
Section: Childhood Abuse Trauma and Schizophreniamentioning
confidence: 99%
“…before age 18) displayed impairments in tasks that rely on frontal and temporal brain areas. Furthermore, females with schizophrenia who reported experiencing childhood physical trauma had significantly more depressive and psychotic symptoms compared to males and females without a history of physical abuse (Kelly et al, 2016). So far, only one study has evaluated the influence of early adversity on post-concussive outcome.…”
Section: Early Adversity and Stressful Eventsmentioning
confidence: 99%