Schizophrenia, “just the facts” 4. Clinical features and conceptualization

Tandon, Rajiv; Nasrallah, Henry A.; Keshavan, Matcheri S.

doi:10.1016/j.schres.2009.03.005

Cited by 845 publications

(664 citation statements)

References 398 publications

Supporting

Mentioning

578

Contrasting

Unclassified

Order By: Relevance

“…These collective findings suggest that affective symptoms may be a core feature of the methamphetamine psychosis, perhaps similar to depression with psychotic features or schizoaffective disorder (Tsuang et al, 1982). Affective symptoms are also commonly seen in people with schizophrenia, including in the prodromal phase of first episode psychosis (Tandon et al, 2009), and can arise secondary to the distress caused by psychotic symptoms (Birchwood, 2003). Further research should elucidate whether the affective syndrome is more prominent in methamphetamine psychosis, or different in nature, than affective symptoms seen in other psychotic disorders.…”

Section: Discussionmentioning

confidence: 99%

“…Although the absence of a negative syndrome is inconsistent with the findings of Srisurapanont et al (2011), only 8% of patients in the Srisurapanont et al study had reported negative symptoms. These symptoms may have been secondary to psychosis or heavy drug use (e.g., due to deprivation, intoxication, or the effects of antipsychotic medication (Tandon et al, 2009)) or the result of misdiagnosis (i.e., patients with schizophrenia being misdiagnosed as having methamphetamine psychosis). Because we only examined symptom exacerbation during periods of methamphetamine use, we cannot discount the possibility that negative symptoms may manifest subsequent to methamphetamine-induced psychosis as part of a residual symptom profile (Tandon et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The profile of psychiatric symptoms exacerbated by methamphetamine use

McKetin

Dawe

Burns

et al. 2016

Drug and Alcohol Dependence

View full text Add to dashboard Cite

Methods: 164 methamphetamine users, who did not meet DSM-IV criteria for a lifetime primary psychotic disorder, were followed monthly for one year to assess the relationship between days of methamphetamine use and symptom severity on the 24-item Brief Psychiatric Rating Scale.Exacerbation of psychiatric symptoms with methamphetamine use was quantified using random coefficient models. The dimensions of symptom exacerbation were examined using principal axis factoring and a latent profile analysis. Results:Symptoms exacerbated by methamphetamine loaded on three factors: positive psychotic symptoms (suspiciousness, unusual thought content, hallucinations, bizarre behavior); affective symptoms (depression, suicidality, guilt, hostility, somatic concern, self-neglect); and psychomotor symptoms (tension, excitement, distractibility, motor hyperactivity). Methamphetamine use did not significantly increase negative symptoms. Vulnerability to positive psychotic and affective symptom exacerbation was shared by 28% of participants, and this vulnerability aligned with a past year DSM-IV diagnosis of substance-induced psychosis (38% vs. 22%, χ 2 (df 1) = 3.66, p = 0.056). Conclusion:Methamphetamine use produced a symptom profile comprised of positive psychotic and affective symptoms, which aligned with a diagnosis of substance-induced psychosis, with no evidence of a negative syndrome.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The profile of psychiatric symptoms exacerbated by methamphetamine use

McKetin

Dawe

Burns

et al. 2016

Drug and Alcohol Dependence

View full text Add to dashboard Cite

show abstract

“…Examples of positive symptoms include hallucinations and delusions, while social withdrawal, lack of motivation and diminished emotional reactivity are considered negative symptoms [8]. Schizophrenia is also often associated with cognitive deficits that may affect functions such as working memory and attention [8]. …”

Section: Introductionmentioning

confidence: 99%

Healthcare resource use in schizophrenia, EuroSC findings

Millier

Horváth

Kóczián

et al. 2017

Journal of Market Access & Health Policy

View full text Add to dashboard Cite

Background: It is unclear if the burden associated with schizophrenia is affected by the type and severity of patient’s symptoms. Objective: This study aims to quantify healthcare resource use associated with different profiles of schizophrenia symptoms. Study design: Post-hoc analysis of data from a naturalistic follow-up study. Setting: Secondary psychiatric services in France, Germany and the UK. Patients: EuroSC cohort:, representative sample of 1,208 schizophrenia patients Main outcome measure: We classified patients into eight health states, according to the Lenert classification (HS1–HS8), and estimated 6-month healthcare resource use (outpatient and day clinic visits, and hospitalisations) across the health states. Results: Approximately half of the patients were classed as having mild symptoms (HS1), with around 20% experiencing moderate, predominantly negative symptoms (HS2). The remaining health states were represented by <10% of patients each. Very few patients experienced extremely severe symptoms (HS8). No health state was associated with excess utilisation across all resource types. In terms of outpatient visits, patients were estimated to see a psychiatrist most often (3.01–4.15 visits over 6 months). Hospital admission was needed in 11%(HS1) – 35%(HS8) of patients and inpatient stays were generally prolonged for all health states (39–57 days). The average number of inpatient days was highest for patients in HS8 (18.17 days), followed by patients with severe negative symptoms (HS4; 13.37 days). In other health states characterised by severe symptoms (HS5–HS7), the average number of inpatient days was approximately half of those seen for HS4 (6.09–7.66). Conclusion: While none of the symptom profiles was associated with excess resource usage, hospitalization days were highest for HS with severe, predominantly negative or extremely severe symptoms. Patients with predominantly negative, moderate or severe symptoms appeared to have a high number of psychologist visits – an interesting finding that may reflect a specific therapeutic approach to the treatment of these patients.

show abstract

“…The clinical presentation of schizophrenia is heterogeneous and its manifestations vary among patients and during the course of the disorder 4 . Symptoms can be divided into five dimensions or syndromes: positive (delusions and hallucinations), negative (affective flattening, avolition, anhedonia, social isolation, and alogy), cognitive (executive dysfunction, memory and attention), disorganization (disorganized speech and behavior) and affective (depression, anxiety, dysphoria and mania) 5 .…”

Section: Introductionmentioning

confidence: 99%

Arterial spin labeling in patients with schizophrenia: a systematic review

Guimarães¹,

Machado‐de‐Sousa²,

Crippa³

et al. 2016

Arch. Clin. Psychiatry (São Paulo)

View full text Add to dashboard Cite

Background: Neuroimaging studies are an invaluable source of information about the physiopathology of schizophrenia. Arterial spin labeling (ASL) is a new magnetic resonance technique (MRI) that is able to effectively evaluate brain function without the use of radiation. Objective: To make a systematic review of studies using ASL to compare resting-state regional cerebral blood flow (rCBF) patterns in patients with schizophrenia and healthy controls. Methods: Original articles were searched for on PubMed, Scopus, Web of Science and PsycINFO electronic databases. The search terms used were 'arterial' , 'spin' , 'labeling' , and 'schizophrenia' . Only studies comparing resting-state rCBF were included, a qualitative synthesis was then performed. Results: Ten articles were included in the review among a total of 22. Decreased rCBF in schizophrenia patients was described in the anterior cingulate, cuneus, fusiform gyrus, frontal lobe, left middle frontal gyrus, inferior frontal gyrus, lingual gyrus, middle occipital gyrus, and parietal lobe. The putamen was the only region with increased rCBF in schizophrenia. Discussion: The evidence of the studies reviewed lends support to the concept of hipofrontality in schizophrenia. rCBF alterations were found in regions classically associated with schizophrenia. ASL seems to be valid, and reliable tool to assess schizophrenia.

show abstract

Schizophrenia, “just the facts” 4. Clinical features and conceptualization

Cited by 845 publications

References 398 publications

The profile of psychiatric symptoms exacerbated by methamphetamine use

The profile of psychiatric symptoms exacerbated by methamphetamine use

Healthcare resource use in schizophrenia, EuroSC findings

Arterial spin labeling in patients with schizophrenia: a systematic review

Contact Info

Product

Resources

About