Schizophrenia Susceptibility and HL-A Antigen

Eberhard, Göran; Franzén, Göran; Löw, Bengt

doi:10.1159/000117496

Cited by 55 publications

(17 citation statements)

References 9 publications

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“…In psychiatry, significant associations have been described in connection with schizophrenia (6,10,27) and with affec tive psychoses by others (3,13,26) and also by our group (2). The results in the field of affective disorders are, however, still incon sistent.…”

mentioning

confidence: 62%

HL-A Antigens and the Response to Prophylactic Lithium

1979

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82 consecutive patients checked at the out-patient clinic of the Psychiatric Department of the Umeå University were typed for HL-A antigens. The patients belonged to the diagnostic subgroups: bipolar (manic-depressive) psychosis (n = 33), unipolar recurrent depressive psychosis (n = 29) and cycloid psychosis (n = 20) and all had been on lithium treatment for at least 6 months. By comparing the group of those who did not relapse on lithium therapy (n = 48) with the group of those who did relapse (n = 34) there was a significantly higher frequency of the HL-A A3 antigens among those who did relapse, and none of those who did not relapse were found to have the HL-A B18 antigens. The results suggest a possible interference between HL-A antigens and response to lithium treatment. However, a large number of antigens were tested and a small number of patients.

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confidence: 62%

HL-A Antigens and the Response to Prophylactic Lithium

1979

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“…However, there is also significant heterogeneity across the studies (p = 0.015) so that in Japanese [Miyanaga et al, 1984] and in Swedish pa tients [Rudduck et al, 1984b] A9 was de creased compared with controls. This is somewhat surprising since in previous studies of schizophrenia as a whole both in Japan [/Isafcaet al, 1981] and Sweden [Eberhard et al, 1975] A9 was increased. Di agnostic differences may be responsible for the differences between centres.…”

Section: Hla Systemmentioning

confidence: 82%

“…Eberhard et al [1975] found a pronounced increase in A9 in older patients. It is possible to spec ulate that this was due to the inclusion of a high proportion of paranoid patients.…”

Section: Unfortunately Subsequent Investigatorsmentioning

confidence: 84%

Genetic Markers in Schizophrenia

McGuffin¹,

Sturt²

1986

Hum Hered

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A genetic contribution to schizophrenia is the best established aetiological clue for this common and serious condition. Purely statistical attempts to establish the mode of inheritance have yielded inconclusive results although SML models where a major gene is the sole cause of concordance between relatives can be effectively excluded. The question of genetic heterogeneity is also unresolved. Genetic marker studies offer potentially productive strategies for detecting major genes for schizophrenia or schizophrenia subtypes, but also offer the possibility of detecting contributory (minor) susceptibility loci. The most consistent genetic marker finding, to date, of an association between HLA A9 and paranoid schizophrenia may fall into the latter category. This and other possible associations discovered by recent population studies (e.g. with complement factors) merit further investigation. On the other hand, the findings of linkage studies, including those with HLA, have been predominantly negative. Recent advances in recombinant DNA technology, and the potential availability of many more polymorphisms, make genetic marker studies an increasingly attractive prospect in schizophrenia. However, as in other disorders with complex and non-Mendelian patterns of inheritance, there remain formidable problems in the statistical analysis of the results.

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“…Contrarily to investigations by other authors where a signifi cant decrease of HLA-A10 was found in schizo phrenic patients, a significant increase was found in our series. Our series did not include patients as old as those in the series by Eberhard et al (6), thus we were unable to divide our patients into comparable subgroups. Also, a subdivision into the classical schizophrenic diagnostic subgroups was not possible, partly because of the small number of patients in vestigated, and partly because most of the patients had been hospitalized for many years and had undergone different clinical phases of the disease.…”

Section: Commentsmentioning

confidence: 97%

“…In a larger series investigated later, the same group (10,11) found a significant ne gative association between HLA-A10 and schizophrenia in 146 patients. Eberhard et al (6) studied the distribution of HLA antigens in 47 chronic schizophrenic patients subdivided in an older and a younger group. They found a significant increase of HLA-A9 in the psychotics as compared to a large group of healthy individuals, the increase being most pronounced in an older subgroup (50 years or older).…”

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confidence: 99%

HLA Antigens in Patients with Schizophrenic Syndromes

Perris¹,

Román²,

Wählby³

1979

Neuropsychobiology

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HLA antigens were studied in 50 patients, 40 males, 10 females and two brothers of patients, all suffering from schizophrenic syndromes. The average duration of illness for the whole group was 18 ± 1.5 years. The frequency of A10 antigen was increased in the schizophrenic patients as compared with 449 healthy individuals. None of the findings concerning HLA and schizophrenia reported in the literature could be verified in the present study. The two ill brothers comprised in the study proved to have the same HLA phenotype as their respective ill sibling. So far there is no conclusive evidence for association between any HLA antigen and ‘schizophrenia’. Further investigations should be concerned with families and not with single patients.

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Schizophrenia Susceptibility and HL-A Antigen

Cited by 55 publications

References 9 publications

HL-A Antigens and the Response to Prophylactic Lithium

HL-A Antigens and the Response to Prophylactic Lithium

Genetic Markers in Schizophrenia

HLA Antigens in Patients with Schizophrenic Syndromes

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