Schizophrenic patients without neuropsychological deficits: subgroup, disease severity or cognitive compensation?

Holthausen, E. A. E.; Wiersma, Durk; Sitskoorn, Margriet M.; Hijman, Ron; Dingemans, Peter; Schene, Aart H.; Bosch, Robert J. van den

doi:10.1016/s0165-1781(02)00184-1

Cited by 79 publications

(71 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A similar discrepancy occurs with regards to disorganization symptoms in schizophrenia (Holthausen et al, 2002;Cobia et al, 2011). …”

Section: Study Aimmentioning

confidence: 84%

“…More specifically, several investigators have reported no significant differences in positive and negative symptom severities between patients with intellectual or cognitive impairments and patients with relatively normal intellect or cognition Holthausen et al, 2002;Kremen et al, 2000;Palmer et al, 1997;Vaskinn et al, 2014). More recent reviews have substantiated previous reports that associations between psychopathology, especially psychotic symptoms, and many standard cognitive tasks used in clinical neuropsychology, are unimpressive and often absent in schizophrenia (Berenbaum et al, 2008;Dibben et al, 2009;Dominguez et al, 2009).…”

Section: Cognition and Psychopathologymentioning

confidence: 94%

“…The third tasks, although the common variance is seldom more than 15% (Ammari et al, 2010;Cobia et al, 2011;de Gracia Dominguez, Viechtbauer, Simons, van Os, & Krabbendam, 2009;Greenwood, Sigmundsson, Morris, & Wykes, 2000;Vaz & Heinrichs, 2006;Palmer et al, 1997), but others failed to find a relationship (Holthausen et al, 2002;Heinrichs et al, 2008;Palmer et al, 1997;Wexler et al, 2009). A similar discrepancy occurs with regards to disorganization symptoms in schizophrenia (Holthausen et al, 2002;Cobia et al, 2011).…”

Section: Study Aimmentioning

confidence: 98%

“…Although some studies found that schizophrenia patients with average range intellectual ability are truly free of other cognitive deficits (Ammari et al, 2010), others found that patients may perform in the average range on a composite score like IQ, but still demonstrate abnormalities in executive, attention-related, memory, and processing speed abilities (Allen et al, 2003;Gray, McMahon, & Gold, 2013;Holthausen et al, 2002;Joyce et al, 2002;Kremen et al, 2000;Weickert et al, 2000) when compared directly with a healthy control group. These cognitive domains are highly vulnerable to many neurological events and disease processes.…”

Section: Study Aimmentioning

confidence: 99%

See 3 more Smart Citations

Preserved, deteriorated, and premorbidly impaired patterns of intellectual ability in schizophrenia.

Ammari¹,

Heinrichs²,

Pinnock³

et al. 2014

Neuropsychology

View full text Add to dashboard Cite

Objective: Although impaired general intellectual ability is a prevalent feature in schizophrenia, patterns suggesting preserved, deteriorated, and premorbidly impaired intellect have also been identified. The main purpose of this investigation was to examine the clinical, cognitive, and neuroanatomical characteristics of these intellectual subtypes, and to establish the value and validity of this approach for reducing the heterogeneity of schizophrenia. Methods: A total of 71 patients with a diagnosis of schizophrenia or schizoaffective disorder and 66 healthy controls were assessed. A 'preserved' performance pattern (n=29) was defined by average-range estimated premorbid and current IQ with no evidence of decline (premorbid-current IQ difference <10 points). A 'deteriorated' pattern (n=14) was defined by a difference between estimated premorbid and current IQ estimates of 10 points or more. A 'premorbidly impaired' pattern (n=14) was defined by below average estimated premorbid and current IQ and no evidence of decline greater than 10 points. The groups were compared on demographic,

show abstract

“…A similar discrepancy occurs with regards to disorganization symptoms in schizophrenia (Holthausen et al, 2002;Cobia et al, 2011). …”

Section: Study Aimmentioning

confidence: 84%

Section: Cognition and Psychopathologymentioning

confidence: 94%

Section: Study Aimmentioning

confidence: 98%

Section: Study Aimmentioning

confidence: 99%

See 2 more Smart Citations

Preserved, deteriorated, and premorbidly impaired patterns of intellectual ability in schizophrenia.

Ammari¹,

Heinrichs²,

Pinnock³

et al. 2014

Neuropsychology

View full text Add to dashboard Cite

show abstract

“…It would likely lead to a more comprehensive assessment, management and prognostication. Although cognitive impairment is not a sine qua non of schizophrenia, as there may be a subgroup who does not show clinically relevant cognitive deficits (3,4), the structure of DSM could easily accommodate this, since most of the disorders in the manual are defined polythetically (5).…”

Section: Institute Of Mental Health Buangkok Greenmentioning

confidence: 99%

Inclusion of cognitive impairment in the DSM diagnosis of schizophrenia: if not now, when?

Chong

2008

World Psychiatry

View full text Add to dashboard Cite

From Comorbidity to Multiple Health Behaviour Change

Baker

Hiles

Thornton

et al. 2013

Emerging Perspectives on Substance Misuse

View full text Add to dashboard Cite

Schizophrenic patients without neuropsychological deficits: subgroup, disease severity or cognitive compensation?

Cited by 79 publications

References 34 publications

Preserved, deteriorated, and premorbidly impaired patterns of intellectual ability in schizophrenia.

Preserved, deteriorated, and premorbidly impaired patterns of intellectual ability in schizophrenia.

Inclusion of cognitive impairment in the DSM diagnosis of schizophrenia: if not now, when?

From Comorbidity to Multiple Health Behaviour Change

Contact Info

Product

Resources

About