Schizophrénie à début précoce et agénésie partielle du corps calleux

Micoulaud-Franchi, Jean-Arthur; Bat-Pitault, F.; Fonséca, D. Da; Rufo, Marcel

doi:10.1016/j.arcped.2010.11.015

Cited by 5 publications

(1 citation statement)

References 21 publications

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“…Given the evidence that agCC was found to be associated with deficits in emotion recognition, labeling of emotional arousal, and decoding visual social cues even in highly functioning and otherwise healthy individuals (Paul et al, 2006; Symington et al, 2011), it is conceivable that callosal dysgenesis in schizophrenia may also be associated with dysfunction in the treatment of emotionally laden information. Two case studies of patients with schizophrenia and agCC provided such evidence (Hallak et al, 2007; Micoulaud-Franchi et al, 2011), but a direct comparison between these kind of individuals and schizophrenia patients with no evidence of callosal abnormality has not been attempted.…”

Section: Introductionmentioning

confidence: 99%

Agenesis of Corpus Callosum and Emotional Information Processing in Schizophrenia

Lungu¹,

Stip²

2012

Front. Psychiatry

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Corpus callosum (CC) is essential in providing the integration of information related to perception and action within a subcortico-cortical network, thus supporting the generation of a unified experience about and reaction to changes in the environment. Its role in schizophrenia is yet to be fully elucidated, but there is accumulating evidence that there could be differences between patients and healthy controls regarding the morphology and function of CC, especially when individuals face emotionally laden information. Here, we report a case study of a patient with partial agenesis of corpus callosum (agCC patient with agenesis of the anterior aspect, above the genu) and we provide a direct comparison with a group of patients with no apparent callosal damage (CC group) regarding the brain activity during the processing of emotionally laden information. We found that although the visual cortex activation in response to visual stimuli regardless of their emotional content was comparable in agCC patient and CC group both in terms of localization and intensity of activation, we observed a very large, non-specific and non-lateralized cerebral activation in the agCC patient, in contrast with the CC group, which showed a more lateralized and spatially localized activation, when the emotional content of the stimuli was considered. Further analysis of brain activity in the regions obtained in the CC group revealed that the agCC patient actually had an opposite activation pattern relative to most participants with no CC agenesis, indicating a dysfunctional response to these kind of stimuli, consistent with the clinical presentation of this particular patient. Our results seem to give support to the disconnection hypothesis which posits that the core symptoms of schizophrenia are related to aberrant connectivity between distinct brain areas, especially when faced with emotional stimuli, a fact consistent with the clinical tableau of this particular patient.

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