Schlemms Canal in OCT Images in Glaucoma Patients and Healthy Subjects

Forgácová, Viera; Lešták, Jan; Pitrová, S; Rozsíval, P; Clinic, V Hurkách Jl; Prague,

doi:10.4172/2155-9570.1000292

Cited by 3 publications

(6 citation statements)

References 8 publications

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“…The mean CSA was found to be significantly larger in the temporal section than in the nasal section (14,552 vs. 13,296 μm 2 ; P < 0.05). This is inconsistent with previous findings by Kagemann et al (2014b ; reviewed in Forgáčová et al, 2013 ) who noted that the mean CSA was significantly smaller in the temporal section in 21 healthy subjects (8,303 vs. 10,983 μm 2 ; P = 0.009). Similarly, Li et al (2017) reported greater CSA on the nasal side in 11 normal eyes (3,839 ± 1,402 mm 2 vs. 3,189 ± 1,209 mm 2 ; P = 0.033).…”

Section: Discussioncontrasting

confidence: 99%

“…With higher scanning resolution, SD-OCT has been proven to be a powerful tool for SC assessment when compared with other measuring instruments, such as ultrasound ( McKee et al, 2013 ; Kagemann et al, 2014a , b ). Forgáčová et al (2013) investigated SCs of 92 eyes from 46 healthy volunteers in the horizontal meridian at 3 and 9 o’clock positions using time-domain OCT. They reported that the external and internal SC diameters were 381.75 and 380.65 μm, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Covered by the trabecular meshwork (TM), SC makes the greatest contribution to the outflow resistance of the aqueous humor. Researchers have determined that most resistance in the aqueous outflow network occurs in the inner wall of the SC ( Forgáčová et al, 2013 ; Yang et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

“…The dimension of SC varies under different circumstances. In healthy subjects who suffered from acute intraocular pressure (IOP) elevation, as well as glaucoma eyes, decreased SC dimensions were reported ( Forgáčová et al, 2013 ; Hong et al, 2013 ; Kagemann et al, 2014b ; Xin et al, 2016 ). According to a recent research, only the CSA and the diameter of SC at the inferior quadrant were negatively associated with IOP changes ( Gao et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

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Age-Related Changes in Human Schlemm’s Canal: An in Vivo Optical Coherence Tomography-Based Study

Zhao

Chen

et al. 2018

Front. Physiol.

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Purpose: To investigate age-related changes in human Schlemm’s canal (SC) using spectral-domain optical coherence tomography (SD-OCT).Methods: A total of 125 normal eyes were imaged using SD-OCT nasally and temporally. The age-related variations of SC sagittal diameter and cross-sectional area (CSA) from four age groups [A (16–20 years), B (21–40 years), C (41–60 years), and D (61–80 years)] were analyzed with Spearman correlation.Results: The positive detection rates of SC showed a significantly downward trend with age. The mean CSA was 13,296 ± 1,897 μm2 nasally and 14,552 ± 2,589 μm2 temporally. The mean CSA was significantly larger in the temporal than in the nasal region (P < 0.05). Nasal CSA values varied among the four age groups (P = 0.004).Conclusion: Our study found for the first time that SC in vivo exhibits a morphological variant with age in healthy humans. Clinicians may need to consider this phenomenon when performing examinations targeting SC for glaucoma patients.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Age-Related Changes in Human Schlemm’s Canal: An in Vivo Optical Coherence Tomography-Based Study

Zhao

Chen

et al. 2018

Front. Physiol.

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“…12 Early investigations and more recent optical coherence tomography studies analyzing primary open-angle glaucoma (POAG) eyes found decreased SC cross-sectional area, perimeter, and length. [13][14][15][16] Histopathologic changes to the outer wall in POAG include increased collapse and narrowing of CCs and intrascleral veins along with adhesion of SC endothelium to CC orifice walls and herniation of JCT with blockage of CC orifices (Gong H, et al IOVS 2007;48:ARVO E-Abstract 2079). [17][18][19] These changes in POAG eyes identify SC and CCs as important anatomic structures for the study of resistance mechanisms to aqueous outflow.…”

mentioning

confidence: 99%

Anatomic Changes in Schlemm's Canal and Collector Channels in Normal and Primary Open-Angle Glaucoma Eyes Using Low and High Perfusion Pressures

Hann

Vercnocke

Bentley

et al. 2014

Invest. Ophthalmol. Vis. Sci.

106

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The 360° circumferential opening of Schlemm's canal in normal individuals detected by enhanced depth imaging optical coherence tomography

Jing

Chen²,

Chen³

et al. 2020

Medicine

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We aimed to observe the opening status and morphological parameters of Schlemm's canal (SC) in normal eyes using enhanced depth imaging optical coherence tomography (EDI-OCT). Consecutive EDI-OCT scans were used to examine the right eye of 20 normal individuals. EDI-OCT was performed clockwise for 8 regions (at the 12:00, 1:30, 3:00, 4:30, 6:00, 7:30, 9:00 and 10:30 o’clock positions). Image processing and analysis in java software was used to measure the area, perimeter, and diameter of SC. Twenty-one serial scans of each region were evaluated and a total of 168 images were included in the analyses of each eye. The SC was detected in 100.0% of the sections. The distribution of individual measurements of SC was highly variable. The mean values of SC size significantly differed among the different clock-face positions. The mean values of the area, perimeter, and diameter of SC in the 9:00 o’clock position were the lowest, and those at the 7:30 o’clock position were the highest (P < .05). There was no obvious association between intraocular pressure and SC size at any clock position. Although SC tends to open circumferentially in normal individuals, the distribution of individual measurements is highly variable. Morphological manifestation of SC measured by EDI-OCT is a useful way to evaluate the circumferential opening status of SC.

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Schlemms Canal in OCT Images in Glaucoma Patients and Healthy Subjects

Cited by 3 publications

References 8 publications

Age-Related Changes in Human Schlemm’s Canal: An in Vivo Optical Coherence Tomography-Based Study

Age-Related Changes in Human Schlemm’s Canal: An in Vivo Optical Coherence Tomography-Based Study

Anatomic Changes in Schlemm's Canal and Collector Channels in Normal and Primary Open-Angle Glaucoma Eyes Using Low and High Perfusion Pressures

The 360° circumferential opening of Schlemm's canal in normal individuals detected by enhanced depth imaging optical coherence tomography

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