Schneider's first rank symptoms and continuous performance disturbance as indices of dysconnectivity of left- and right-hemispheric components of language in schizophrenia

Ceccherini-Nelli, Alfonso; Turpin-Crowther, Karen; Crow, Timothy J.

doi:10.1016/j.schres.2006.09.017

Cited by 22 publications

(25 citation statements)

References 39 publications

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“…On these tasks, the patients with FRS actually tended to perform better than the FRS-ones. Overall, we do not replicate the findings of language disturbances in FRS [26,28] . Indeed the current results are consistent with those reported by Verdoux et al [27] , indicating an advantage for FRS+ patients in language abilities.…”

Section: Discussioncontrasting

confidence: 99%

“…This result underscores other findings of reduced right-hand preference in FRS patients [26,27] by showing decreased lateralization for a range of motor (hand, foot and eye) activities. An analysis of z-scores and effect sizes also indicated a trend towards less lateralization of another motor test (Tapping Task) and language functions (Dichotic Listening NF LQ) in the FRS+ group relative to both the FRS-patients and healthy controls, consistent with the proposal advocating reduced cerebral asymmetry.…”

Section: Discussionsupporting

confidence: 87%

“…Another proposed test of this hypothesis involves examination of speech disturbances. In 2 separate studies, Ceccherini-Nelli et al [26] and CeccheriniNelli and Crow [28] reported positive correlations between FRS scores and factor scores on the Clinical Language Disorder Rating Scale. However, Verdoux et al [27] showed that higher FRS scores were associated with less impairment on another language scale, providing contrary findings for the proposal of language dis turbances in FRS.…”

Section: Introductionmentioning

confidence: 96%

“…One consequence of these abnormalities is thought to be a blurring of the boundaries between externally and internally generated speech and actions. Evidence for decreased lateralization is based on a reported association between reduced right-hand preference and FRS [26,27] . Another proposed test of this hypothesis involves examination of speech disturbances.…”

Section: Introductionmentioning

confidence: 99%

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Neuropsychological Functioning in Schizophrenia Patients with First-Rank (Passivity) Symptoms

et al. 2009

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Background: In this study, we conducted a broad investigation of neuropsychological functioning in schizophrenia patients with first-rank (passivity) symptoms (FRS) using standardized cognitive tests. We focused on 3 neuropsychological domains, partly informed by 3 broad hypotheses concerning the pathogenesis of FRS. We tested predictions that patients with FRS would show: (i) memory deficits consistent with abnormalities in medial temporal lobe functioning; (ii) reduced cerebral lateralization on tasks of motor and language functions, and (iii) deficits on tasks of executive functions as a measure of the integrity of the prefrontal cortex for supporting self-monitoring processes. Sampling and Methods: In 2 parallel studies, we administered a range of neuropsychological tests to patients with FRS (sample A = 17, sample B = 15) and without FRS (sample A = 28, sample B = 20) and to healthy controls (sample A = 109, sample B = 22). Results: The results showed reduced cerebral lateralization in patients with FRS, but there were no memory deficits or executive dysfunctions relative to patients without FRS. An unexpected finding was that, on many cognitive tasks, the performance of the patients with FRS was relatively spared compared to that of the patients without FRS. These results could not be accounted for by demographic features or medication effects. Conclusions: Our results provide qualified support for the reduced lateralization hypothesis. Analyses of performance across neuropsychological domains showed that generalized deficit is not a sufficient explanation for the occurrence of FRS.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Neuropsychological Functioning in Schizophrenia Patients with First-Rank (Passivity) Symptoms

et al. 2009

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“…Language disorganization is an observable expression of formal thought disorder (FTD) that has been strongly associated with clinical expression and broader neurocognitive deficits in psychotic disorders, including schizophrenia-spectrum disorders (Kerns and Berenbaum, 2002;Subotnik et al, 2006;Ceccherini-Nelli et al, 2007). Previous studies have demonstrated a close association between FTD and other symptomotology in schizophrenia-spectrum disorders, such as delusions and hallucinations, (Andreasen and Grove, 1986;Harrow and Marengo, 1986;Kimhy et al, 2005;Strik et al, 2008), implicating it as a clinical indicator of acute psychotic states.…”

Section: Introductionmentioning

confidence: 99%

Executive function as predictors of persistent thought disorder in first-episode schizophrenia: A one-year follow-up study

Hui

Longenecker

et al. 2014

Schizophrenia Research

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Functional and anatomical connectivity abnormalities in left inferior frontal gyrus in schizophrenia

Jeong

Wible

Hashimoto

et al. 2009

Human Brain Mapping

106

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Functional studies in schizophrenia demonstrate prominent abnormalities within the left inferior frontal gyrus(IFG) and also suggest the functional connectivity abnormalities in language network including left IFG and superior temporal gyrus during semantic processing. White matter connections between regions involved in the semantic network have also been indicated in schizophrenia. However, an association between functional and anatomical connectivity disruptions within the semantic network in schizophrenia has not been established. Functional (using Levels of Processing paradigm) as well as Diffusion Tensor Imaging data from 10 controls and 10 chronic schizophrenics were acquired and analyzed. First, semantic encoding specific activation was estimated, showing decreased activation within the left IFG in schizophrenia. Second, functional time series were extracted from this area, and left IFG specific functional connectivity maps were produced for each subject. In an independent analysis, Tract-Based Spatial Statistics(TBSS) was used to compare Fractional Anisotropy(FA) values between groups, and to correlate these values with functional connectivity maps. Schizophrenia patients showed weaker functional connectivity within the language network that includes left IFG and left superior temporal sulcus/middle temporal gyrus. FA was reduced in several white matter regions including left inferior frontal and left internal capsule. Finally, left inferior frontal white matter FA was positively correlated with connectivity measures of the semantic network in schizophrenics, but not in controls. Our results indicate an association between anatomical and functional connectivity abnormalities within the semantic network in schizophrenia, suggesting further that the functional abnormalities observed in this disorder might be directly related to white matter disruptions.

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Schneider's first rank symptoms and continuous performance disturbance as indices of dysconnectivity of left- and right-hemispheric components of language in schizophrenia

Cited by 22 publications

References 39 publications

Neuropsychological Functioning in Schizophrenia Patients with First-Rank (Passivity) Symptoms

Neuropsychological Functioning in Schizophrenia Patients with First-Rank (Passivity) Symptoms

Executive function as predictors of persistent thought disorder in first-episode schizophrenia: A one-year follow-up study

Functional and anatomical connectivity abnormalities in left inferior frontal gyrus in schizophrenia

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