Schneiderian Papillomas and Nonsalivary Glandular Neoplasms of the Head and Neck

Barnes, Leon

doi:10.1038/modpathol.3880524

Cited by 163 publications

(208 citation statements)

References 161 publications

(170 reference statements)

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“…It is most common in inverted papillomas, with rates as low as 2 % and as high as 27 % reported. Most of the literature, including a large collective literature review by Barnes in 2002 of 1390 patients [4], suggests that it is *10 %. Given that a recent, large series showed a rate of only 1.9 % [5], the actual rate is probably between these two figures.…”

Section: Precursor Lesionsmentioning

confidence: 99%

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Sinonasal Squamous Cell Carcinoma: A Review with Emphasis on Emerging Histologic Subtypes and the Role of Human Papillomavirus

Lewis

2016

Head and Neck Pathol

110

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The sinonasal tract is one of the least frequent sites for squamous cell carcinoma in the head and neck. However, it is still a complex tumor type for pathologists because there are numerous histologic variants with unusual morphologic features, several non-squamous carcinomas in the differential diagnosis that can have similar morphology and even squamous differentiation, and because of the increasing recognition of human papillomavirus (HPV) in a subset of the tumors. In addition, the unique and complex anatomy of the sinonasal tract can make proper staging and management of patients' tumors quite challenging. This article reviews sinonasal tract squamous cell carcinoma in depth and provides the latest data on Schneiderian papillomas and HPV in their pathogenesis.

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Section: Precursor Lesionsmentioning

confidence: 99%

“…Approximately 60 % of the SCC arising from inverted papillomas present synchronously. Data on rates of SCC in oncocytic papillomas are much less reliable because of their rarity, but range between 4 and 17 % [4]. The histologic features of the SCCs, and the role of HPV are discussed below.…”

Section: Precursor Lesionsmentioning

confidence: 99%

Sinonasal Squamous Cell Carcinoma: A Review with Emphasis on Emerging Histologic Subtypes and the Role of Human Papillomavirus

Lewis

2016

Head and Neck Pathol

110

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“…The published frequency of these subtypes varies by study, but the inverted type is the most common, accounting for nearly two thirds of cases. Fungiform and oncocytic types account for nearly one third and about 5 %, respectively [1][2][3]. The clinical and morphological features of each are quite distinct, and although some overlap exists, they should not be lumped together for diagnostic purposes as ''Schneiderian papilloma'' without further qualification.…”

Section: Schneiderian Papillomas Backgroundmentioning

confidence: 99%

Low-Grade Epithelial Proliferations of the Sinonasal Tract

Bullock

2016

Head and Neck Pathol

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Low-grade epithelial proliferations of the sinonasal tract include Schneiderian papillomas, respiratory epithelial adenomatoid hamartoma, seromucinous hamartoma and low-grade non-intestinal adenocarcinoma. There is considerable overlap in their clinical presentation, endoscopic appearance, and imaging features. Although well-described diagnostic criteria exist, a definitive diagnosis may be difficult to reach on a small biopsy. Schneiderian papillomas are divided into fungiform, inverted, and oncocytic types, each with characteristic clinical and morphological features. The latter two may progress to malignancy. The majority are still considered to be HPVrelated. Two lesions are designated as hamartomas, but their pathogenesis remains uncertain, with inflammatory and neoplastic origins proposed. Respiratory epithelial adenomatoid hamartoma is increasingly being recognized for its association with chronic rhinosinusitis and olfactory cleft site of origin. Seromucinous hamartoma has gained attention in recent years and overlaps with both respiratory epithelial adenomatoid hamartoma and low-grade non-intestinal adenocarcinoma. Controversy surrounds their distinction, particularly from low-grade adenocarcinoma. The latter generally is cured by complete excision, with a 26 % risk of recurrence but rare metastases and deaths from disease.

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“…It is a rare sinonasal tumor comprising only 0.5-4% of all nasal tumors [1]. Although this tumor is benign in nature, it exhibits the characteristics of local invasiveness, recurrence, and malignant transformation [2][3][4][5].The incidence of malignant change in individual series of inverted papillomas ranges from 2 to 27% [6]. Recently, it was reported that there is a clear relationship between paranasal IP and squamous cell carcinoma (SCC), and that nearly 10% of inverted papillomas are associated with SCC [7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of P53, P63, P21, P27, Ki-67 in Paranasal Sinus Squamous Cell Carcinoma and Inverted Papilloma

Öncel

Cosgul

Çallı

et al. 2011

Indian J Otolaryngol Head Neck Surg

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Using a molecular genetic approach, we try to confirm the molecular alterations of inverted papilloma and clarify its status as a putative precursor lesion of sinonasal squamous cell carcinoma. To better understand its genetics, we investigated the immunohistochemical protein expression patterns of cell-cycle-regulators p53, p63, p21, p27 and proliferation marker Ki-67 in 22 inverted papilloma and 9 squamous cell carcinoma of the sinonasal tract. Significantly elevated levels of p53 and p63 in squamous cell carcinoma of sinonasal tract compared with inverted papilloma were revealed. Ki-67-stained neoplastic cell nuclei were found in a significantly higher percentage of squamous cell carcinoma of sinonasal tract than in inverted papilloma, whereas no variation of p21 and p27 expression was identified. This work first examined the immunohistochemical overexpression of p63 in sinonasal inverted papilloma and squamous cell carcinoma. In conclusion, this is a first study shedding light on the expression of p63 in tumors of paranasal sinuses.

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Schneiderian Papillomas and Nonsalivary Glandular Neoplasms of the Head and Neck

Abstract: Schneiderian papillomas and nonsalivary glandular neoplasms of the head and neck continue to be a source of confusion for both the clinician and pathologist. An update on these lesions is provided.

Cited by 163 publications

References 161 publications

Sinonasal Squamous Cell Carcinoma: A Review with Emphasis on Emerging Histologic Subtypes and the Role of Human Papillomavirus

Sinonasal Squamous Cell Carcinoma: A Review with Emphasis on Emerging Histologic Subtypes and the Role of Human Papillomavirus

Low-Grade Epithelial Proliferations of the Sinonasal Tract

Evaluation of P53, P63, P21, P27, Ki-67 in Paranasal Sinus Squamous Cell Carcinoma and Inverted Papilloma

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