Schneiderian Papillomas: Comparative Review of Exophytic, Oncocytic, and Inverted Types

Vorasubin, Nopawan; Vira, Darshni; Suh, Jeffrey D.; Bhuta, Sunita; Wang, Marilene B.

doi:10.2500/ajra.2013.27.3904

Cited by 107 publications

(127 citation statements)

References 28 publications

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“…2a). There may be focal hyperostosis or osteitis within the sinuses [1]. Pressure erosion of bone may occur, but not destructive invasion.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…FSP almost exclusively arise on the nasal septum (preferentially anterior), with a small minority involving or arising from the lateral nasal wall, turbinates, or vestibule [1]. Involvement of paranasal sinuses is extremely rare.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…Papillomas are commonly associated with chronic rhinosinusitis, particularly ISP and OSP, but a causal association has not been proven. They typically occur in adults, with a mean age in the 6th decade for ISP and OSP, and slightly younger for FSP [1]. ISP and FSP are more common in men (male to female ratio of 3-4:1), with an equal gender distribution for OSP.…”

Section: Schneiderian Papillomas Backgroundmentioning

confidence: 99%

“…The published frequency of these subtypes varies by study, but the inverted type is the most common, accounting for nearly two thirds of cases. Fungiform and oncocytic types account for nearly one third and about 5 %, respectively [1][2][3]. The clinical and morphological features of each are quite distinct, and although some overlap exists, they should not be lumped together for diagnostic purposes as ''Schneiderian papilloma'' without further qualification.…”

Section: Schneiderian Papillomas Backgroundmentioning

confidence: 99%

“…They may be multiple, but are rarely bilateral. Presentation is with obstructive symptoms, epistaxis, or as an incidentally identified mass [1,2]. Imaging studies are not typically performed, but might show soft tissue thickening along the septum, with no septal destruction.…”

Section: Clinical Featuresmentioning

confidence: 99%

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Low-Grade Epithelial Proliferations of the Sinonasal Tract

Bullock

2016

Head and Neck Pathol

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Low-grade epithelial proliferations of the sinonasal tract include Schneiderian papillomas, respiratory epithelial adenomatoid hamartoma, seromucinous hamartoma and low-grade non-intestinal adenocarcinoma. There is considerable overlap in their clinical presentation, endoscopic appearance, and imaging features. Although well-described diagnostic criteria exist, a definitive diagnosis may be difficult to reach on a small biopsy. Schneiderian papillomas are divided into fungiform, inverted, and oncocytic types, each with characteristic clinical and morphological features. The latter two may progress to malignancy. The majority are still considered to be HPVrelated. Two lesions are designated as hamartomas, but their pathogenesis remains uncertain, with inflammatory and neoplastic origins proposed. Respiratory epithelial adenomatoid hamartoma is increasingly being recognized for its association with chronic rhinosinusitis and olfactory cleft site of origin. Seromucinous hamartoma has gained attention in recent years and overlaps with both respiratory epithelial adenomatoid hamartoma and low-grade non-intestinal adenocarcinoma. Controversy surrounds their distinction, particularly from low-grade adenocarcinoma. The latter generally is cured by complete excision, with a 26 % risk of recurrence but rare metastases and deaths from disease.

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“…2a). There may be focal hyperostosis or osteitis within the sinuses [1]. Pressure erosion of bone may occur, but not destructive invasion.…”

Section: Clinical Featuresmentioning

confidence: 99%

Section: Clinical Featuresmentioning

confidence: 99%

Section: Schneiderian Papillomas Backgroundmentioning

confidence: 99%

Section: Schneiderian Papillomas Backgroundmentioning

confidence: 99%

Section: Clinical Featuresmentioning

confidence: 99%

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Low-Grade Epithelial Proliferations of the Sinonasal Tract

Bullock

2016

Head and Neck Pathol

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A Growing Mass in the Nostril

Barboza-Guadagnini

Shendrik²,

Garcia³

2017

JAMA Dermatol

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A man in his 30s presented with a mass in the right nostril that had been growing for about 1 year. The lesion bled with minimal trauma but did not obstruct his breathing. The patient did not smoke and denied any medical history of chronic rhinosinusitis. Physical examination revealed a 1-cm, nontender, exophytic, verrucous, skin-colored plaque on the right nasal vestibule (Figure , A and B). A diagnostic shave biopsy specimen was taken after informed consent was obtained (Figure , C and D). Clinical image A Clinical image B Histologic image C Histologic image D Figure. A and B, An exophytic, verrucous, and skin-colored plaque on the right nasal vestibule. C, Histologic sections display papillary fronds with slender fibrovascular cores that are lined by nonkeratinizing squamous epithelium (original magnification ×200). D, Higher magnification shows mucin-containing goblet cells. Neither cytologic atypia nor atypical mitotic figures are present (original magnification ×400).

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International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

Kuan

Wang

Adappa

et al. 2024

Int Forum Allergy Rhinol

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BackgroundSinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represents a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and presents 48 thematic and histopathology‐based topics spanning the field.MethodsIn accordance with prior ICAR documents, ICSNT assigned each topic as an Evidence‐Based Review with Recommendations, Evidence‐Based Review, and Literature Review based on level of evidence. An international group of multidisciplinary author teams were assembled for the topic reviews using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses format, and completed sections underwent a thorough and iterative consensus‐building process. The final document underwent rigorous synthesis and review prior to publication.ResultsThe ICNST document consists of 4 major sections: general principles, benign neoplasms and lesions, malignant neoplasms, and quality of life and surveillance. It covers 48 conceptual and/or histopathology‐based topics relevant to sinonasal neoplasms and masses. Topics with a high level of evidence provided specific recommendations, while other areas summarized the current state of evidence. A final section highlights research opportunities and future directions, contributing to advancing knowledge and community intervention.ConclusionAs an embodiment of the multidisciplinary and collaborative model of care in sinonasal neoplasms and masses, ICSNT was designed as a comprehensive, international, and multidisciplinary collaborative endeavor. Its primary objective is to summarize the existing evidence in the field of sinonasal neoplasms and masses.This article is protected by copyright. All rights reserved

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Schneiderian Papillomas: Comparative Review of Exophytic, Oncocytic, and Inverted Types

Abstract: ABSTRACT

Cited by 107 publications

References 28 publications

Low-Grade Epithelial Proliferations of the Sinonasal Tract

Low-Grade Epithelial Proliferations of the Sinonasal Tract

A Growing Mass in the Nostril

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors

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