Schnellere Zentrifugen ins Laboratorium!

Schmidt-Lange, W.

doi:10.1007/bf02071936

Cited by 2 publications

(1 citation statement)

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“…The antimicrobial effects of bee venom have been widely evaluated for many years. [ 55 ] MLT has become a promising effectual agent against drug‐resistant bacteria due to its potent activity on cell membranes and pore formation. [ 56,57 ] Some of the prominent cases where the effects of MLT have been examined are as follows.…”

Section: Anti‐inflammatory Effects Of Mlt On Various Diseasesmentioning

confidence: 99%

Immunomodulatory activities and biomedical applications of melittin and its recent advances

Jafari,

Sadeghi,

Dehaghi

et al. 2024

Archiv der Pharmazie

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Melittin (MLT), a peptide containing 26 amino acids, is a key constituent of bee venom. It comprises ∼40%–60% of the venom's dry weight and is the main pricing index for bee venom, being the causative factor of pain. The unique properties of MLT extracted from bee venom have made it a very valuable active ingredient in the pharmaceutical industry as this cationic and amphipathic peptide has propitious effects on human health in diverse biological processes. It has the ability to strongly impact the membranes of cells and display hemolytic activity with anticancer characteristics. However, the clinical application of MLT has been limited by its severe hemolytic activity, which poses a challenge for therapeutic use. By employing more efficient mechanisms, such as modifying the MLT sequence, genetic engineering, and nano‐delivery systems, it is anticipated that the limitations posed by MLT can be overcome, thereby enabling its wider application in therapeutic contexts. This review has outlined recent advancements in MLT's nano‐delivery systems and genetically engineered cells expressing MLT and provided an overview of where the MLTMLT's platforms are and where they will go in the future with the challenges ahead. The focus is on exploring how these approaches can overcome the limitations associated with MLT's hemolytic activity and improve its selectivity and efficacy in targeting cancer cells. These advancements hold promise for the creation of innovative and enhanced therapeutic approaches based on MLT for the treatment of cancer.

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Section: Anti‐inflammatory Effects Of Mlt On Various Diseasesmentioning

confidence: 99%