Scholarisines H–O, novel indole alkaloid derivatives from long-term stored Alstonia scholaris

The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research

“…The oxidized furoindoline motif in 87a is embedded within a polycyclic framework, referred to as “indolinolid” in the original report 205. Although the molecular framework of 87a was the first of its kind, the akuammiline MIAs have since been expanded by nine congeners: picranitine,208 alstolactines A, B, and C,209 alstoniascholarines L and M,210 as well as scholarisines K, L, and M 211…”

Acute and Chronic Toxicity of Indole Alkaloids from Leaves of Alstonia scholaris (L.) R. Br. in Mice and Rats

“…The leaves have long been used in "dai" ethno-pharmacy to treat postinfectious cough, chronic bronchitis, asthma, and other respiratory tract infections in Yunnan Province, China [6]. The authors of this paper have investigated intensively the phytochemical constituents of the different parts of the plant [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. The chemical profile and metabolites of alkaloidal extract of leaves of A. scholaris indicate that scholaricine, 19-epischolaricine, vallesamine, and picrinine are the major indole alkaloids [27,28].…”

Effects of indole alkaloids from leaf of Alstonia scholaris on post-infectious cough in mice

“…Its leaves have long been used in "dai" ethno-pharmacy for the treatment of whooping cough (post infectious cough), chronic bronchitis, asthma, and other respiratory tract infections in Yunnan Province, PR China (Compiling Group of Yunnan Traditional Chinese Medicine, 1977). Phytochemical constituents of different parts of the plant were investigated intensively by our group (Cai et al, 2010(Cai et al, , 2008a(Cai et al, , 2008b(Cai et al, , 2007Chen et al, 2016;Du et al, 2007aDu et al, , 2007bFeng et al, 2009Feng et al, , 2008Liu et al, 2015;Pan et al, 2016;Qin et al, 2015aQin et al, , 2015bXu et al, 2009;Yang et al, 2015aYang et al, , 2015bYang et al, , 2014aYang et al, , 2014bZhang et al, 2014;Zhou et al, 2005). Meanwhile, the chemical profiling and metabolites of alkaloidal extract of A. scholaris were reported (Cao et al, 2015), in which scholaricine, 19-epischolaricine, vallesamine, and picrinine were the major indole alkaloids of its leaf ( Fig.…”