Rural schools are key places for accessing children needing supportive mental and behavioral healthcare services (Crumb et al., 2021). With appropriate supports and interventions that integrate trauma-informed principles, rural youth can overcome traumatic and adverse childhood experiences that impact their well-being, such as physical and emotional abuse, poverty, homelessness, exposure to household dysfunction, substance use, parental separation, and accidents and injuries (Center for Disease Control, 2021). The Substance Abuse and Mental Health Services Administration (SAMHSA) outlined six principles that guide a trauma-informed approach: 1) safety; 2) trustworthiness and transparency; 3) peer support; 4) collaboration and mutuality; 5) empowerment, voice, and choice; and 6) cultural, historical and gender issues (SAMHSA, 2014). All rural school personnel can embrace a culturally responsive approach and translate into practice value-driven approaches to student learning and services that leverage healing from adversity and minimize the risk of re-traumatization guided by these principles. This is especially important as childhood, adolescence, and emerging adulthood are sensitive developmental periods in which healing from adversity can occur (Cantor et al., 2018;Duane et al., 2021;Simmons, 2021). Furthermore, adopting SAMHSA's principles using a culturally responsive approach supports the wellbeing of rural school personnel who are at risk of experiencing burnout and compassion fatigue from working with students who have experienced trauma or who may be dealing with their adversities (Mullen & Gutierrez, 2016;Ruble et al., 2023).A combination of strengths-based school and community interventions may circumvent barriers to mental health treatment faced by rural students, school staff, families, and community members, such as time and resource constraints, transportation difficulties, communication breakdowns, and gaps in mental health literacy (Fears et al., 2023;Mingo & Cofield, 2023). These interventions also aid in reducing the stigma associated with seeking mental health services in rural areas (Crowe & Kim, 2020;Crumb et al., 2019). In this special issue of the Theory & Practice in Rural Education journal (TPRE), we highlight a range of articles that capture research and professional practices that promote cultural and trauma competence in rural settings and uphold the six guiding principles of a trauma-informed approach to help build resiliency and decrease the