This paper summarizes the key findings from a systematic literature review that sought to identify existing evidence about the ways in which the needs of neglected children and their parents are signalled and the response to those needs. Using systematic review guidelines, 14 databases were searched for primary research studies published in English from 1995 to 2005. An initial 20 480 items were systematically filtered down to 63 papers for inclusion. The evidence suggests that, while there is little evidence about how needs for help are directly signalled, there is considerable evidence about how needs are indirectly signalled. There is evidence that professionals can identify signs of neglect, but are not always clear about the best response. There remain gaps in evidence about how best to respond to neglected needs, especially within schools