School Performance After Preterm Birth

Ahlsson, Fredrik; Kaijser, Magnus; Adami, Johanna; Lundgren, Maria; Palme, Mårten

doi:10.1097/ede.0000000000000171

Cited by 41 publications

(50 citation statements)

References 22 publications

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“…Large Scandinavian register-based data analyses have found associations between preterm birth and a wide range of educational, social, cognitive and mental health outcomes in adolescence and young adulthood [2–4, 18, 23–27]. However, a causal relationship between preterm birth and cognition was recently questioned in a Swedish analysis which showed that the effect of preterm birth (<30 weeks) on low school grades attenuated in sibling analyses[28]. …”

Section: Discussionmentioning

confidence: 99%

Premature Adult Death in Individuals Born Preterm: A Sibling Comparison in a Prospective Nationwide Follow-Up Study

et al. 2016

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BackgroundClose to one in ten individuals worldwide is born preterm, and it is important to understand patterns of long-term health and mortality in this group. This study assesses the relationship between gestational age at birth and early adult mortality both in a nationwide population and within sibships. The study adds to existing knowledge by addressing selected causes of death and by assessing the role of genetic and environmental factors shared by siblings.MethodsStudy population was all Norwegian men and women born from 1967 to 1997 followed using nation-wide registry linkage for mortality through 2011 when they were between 15 and 45 years of age. Analyses were performed within maternal sibships to reduce variation in unobserved genetic and environmental factors shared by siblings. Specific outcomes were all-cause mortality and mortality from cardiovascular diseases, cancer and external causes including accidents, suicides and drug abuse/overdoses.ResultsCompared with a sibling born in week 37–41, preterm siblings born before 34 weeks gestation had 50% increased mortality from all causes (adjusted Hazard Ratio (aHR) 1.54, 95% confidence interval (CI) 1.17, 2.03). The corresponding estimate for the entire population was 1.27 (95% CI 1.09, 1.47). The majority of deaths (65%) were from external causes and the corresponding risk estimates for these deaths were 1.52 (95% CI 1.08, 2.14) in the sibships and 1.20 (95% CI 1.01, 1.43) in the population.ConclusionPreterm birth before week 34 was associated with increased mortality between 15 and 45 years of age. The results suggest that increased premature adult mortality in this group is related to external causes of death and that the increased risks are unlikely to be explained by factors shared by siblings.

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Section: Discussionmentioning

confidence: 99%

Premature Adult Death in Individuals Born Preterm: A Sibling Comparison in a Prospective Nationwide Follow-Up Study

et al. 2016

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“…3 Increased utilization of resources in early life, increased need for early intervention services, and reduced school performance are more common among survivors of preterm birth, resulting in significant societal costs. 4–6 …”

Section: Introductionmentioning

confidence: 99%

The phenotype of spontaneous preterm birth: application of a clinical phenotyping tool

Manuck

Esplin

Biggio

et al. 2015

American Journal of Obstetrics and Gynecology

112

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Objective Spontaneous preterm birth (SPTB) is a complex condition that is likely a final common pathway with multiple possible etiologies. We hypothesized that a comprehensive classification system could appropriately group women with similar STPB etiologies, and provide an explanation, at least in part, for the disparities in SPTB associated with race and gestational age at delivery. Study Design Planned analysis of a multicenter, prospective study of singleton SPTB. Women with SPTB < 34 weeks were included. We defined 9 potential SPTB phenotypes based on clinical data, including infection/inflammation, maternal stress, decidual hemorrhage, uterine distention, cervical insufficiency, placental dysfunction, premature rupture of the membranes, maternal comorbidities, and familial factors. Each woman was evaluated for each phenotype. Delivery gestational age was compared between those with and without each phenotype. Phenotype profiles were also compared between women with very early (20.0–27.9 weeks) SPTB vs. those with early SPTB (28.0–34.0 weeks), and between African-American and Caucasian women. Statistical analysis was by t-test and chi-square as appropriate. Results The phenotyping tool was applied to 1025 women with SPTB who delivered at a mean 30.0 (+/− 3.2) weeks gestation. Of these, 800 (78%) had ≥2 phenotypes. Only 43 (4.2%) had no phenotypes. The 281 women with early SPTB were more likely to have infection/inflammation, decidual hemorrhage, and cervical insufficiency phenotypes (all p≤0.001). African-American women had more maternal stress and cervical insufficiency but less decidual hemorrhage and placental dysfunction compared to Caucasian women (all p<0.05). Gestational age at delivery decreased as the number of phenotypes present increased. Conclusions Precise SPTB phenotyping classifies women with SPTB and identifies specific differences between very early and early SPTB and between African-Americans and Caucasians.

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“…Following the advances in perinatal care, an increasing number of preterm infants reach childhood (2). Negative effects of preterm birth on neurodevelopmental and psychiatric development of children and adolescents have been well documented (3)(4)(5)(6)(7)(8). Severe neurological impairment has been reported in 10 to 12% of school-aged children, who were born very preterm (less than 32 weeks of gestation) (9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Effect of Neonatal Intensive Care Unit Hospitalization on Incidence of Attention Deficit Hyperactivity Disorder in Preschool Children

Baboli

Pasha

Mousavi

et al. 2016

Iran J Psychiatry Behav Sci

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School Performance After Preterm Birth

Abstract: Our study suggests that the association between school performance and preterm birth after 30 gestational weeks is attributable to factors other than preterm birth per se.

Cited by 41 publications

References 22 publications

Premature Adult Death in Individuals Born Preterm: A Sibling Comparison in a Prospective Nationwide Follow-Up Study

Premature Adult Death in Individuals Born Preterm: A Sibling Comparison in a Prospective Nationwide Follow-Up Study

The phenotype of spontaneous preterm birth: application of a clinical phenotyping tool

Effect of Neonatal Intensive Care Unit Hospitalization on Incidence of Attention Deficit Hyperactivity Disorder in Preschool Children

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