The goal of this paper is to develop the theory of Schur complementation in the context of operators acting on anti-dual pairs. As a byproduct, we obtain a natural generalization of the parallel sum and parallel difference, as well as the Lebesgue-type decomposition. To demonstrate how this operator approach works in application, we derive the corresponding results for operators acting on rigged Hilbert spaces, and for representable functionals of * -algebras.2010 Mathematics Subject Classification. Primary 47B65, Secondary 28A12, 46K10.