Schwangerschaftsspezifisches Protein (SP-1): klinische Aspekte

Variations in some of the body fluid hormone levels currently used for endocrine monitoring during the third trimester of pregnancy

“…The Standard deviations were great for the steroids (especially for E 4 ) and much less for the proteins (especially SPi). This implies that it is necessary to have serial assays of the steroids to have any confidence in [3,23], against a 20 minute half-life for HPL [24]. This means that even though a single assay may give more accurate picture of placental function [26], if HPL samples taken closer together are assayed, one can have a more up-to-the-minute indication of the development of a pathological condition in J. Perinat.…”

Pregnancy‐Specific β1Glycoprotein, SP1 in Maternal Serum During Uncomplicated Single Pregnancies

“…Interestingly, the maternal SP1 level in late pregnancy was found to show a weak but significant correlation with both the birth weight of the infant and the placental weight, a finding also reported by other authors (10,34,39). The clinical significance of these relationships is not clear at present.…”

Quantitative analysis of pregnancy-associated plasma proteins in human placenta.

“…Although these observations do not necessarily indicate that the PAPP's are synthesized in placenta, other findings support this interpretation of the data: (a) all of the PAPP's rapidly disappeared from the maternal circulation after childbirth (7); (b) immunofluorescence studies showed that PAPP-A, PAPP-C, and HCS were strongly localized in the trophoblast, while PZP was found diffusely in placental tissue (17); and (c) the placental weight has been found to be significantly correlated with maternal PAPP-A, PAPP-C, as well as HCS concentrations (18,19).' In addition, the present study also failed to reveal binding of PAPP's by placental tissue residues, indicating that the elevated PAPP levels in placenta were not due to a receptor type of localization of these proteins synthesized elsewhere.…”