Schwann cell precursors: Where they come from and where they go

Solovieva, Tatiana; Bronner, Marianne E.

doi:10.1016/j.cdev.2021.203686

Cited by 18 publications

(18 citation statements)

References 68 publications

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“…We note too that work in mouse and lamprey has recently provided evidence for a contribution of Schwann cell precursors to the enteric neuron population [84,85]; we would predict that the same is likely in zebrafish. Finally, we note how our observations support the growing awareness of the breadth of multipotency of Schwann cell precursors [33,[86][87][88][89][90].…”

Section: Zebrafish Pigment Cell Developmentsupporting

confidence: 76%

Cell Fate Decisions in the Neural Crest, from Pigment Cell to Neural Development

Dawes

Kelsh

2021

IJMS

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The neural crest shows an astonishing multipotency, generating multiple neural derivatives, but also pigment cells, skeletogenic and other cell types. The question of how this process is controlled has been the subject of an ongoing debate for more than 35 years. Based upon new observations of zebrafish pigment cell development, we have recently proposed a novel, dynamic model that we believe goes some way to resolving the controversy. Here, we will firstly summarize the traditional models and the conflicts between them, before outlining our novel model. We will also examine our recent dynamic modelling studies, looking at how these reveal behaviors compatible with the biology proposed. We will then outline some of the implications of our model, looking at how it might modify our views of the processes of fate specification, differentiation, and commitment.

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Section: Zebrafish Pigment Cell Developmentsupporting

confidence: 76%

Cell Fate Decisions in the Neural Crest, from Pigment Cell to Neural Development

Dawes

Kelsh

2021

IJMS

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“…In addition to these peripheral autonomic neurons, neuralcrest-derived sympathoblasts also produce SCPs (Figure 2) (Bechmann et al, 2021;Furlan et al, 2017). SCPs are multipotent progenitor cells that can differentiate into Schwann cells, as well as melanocytes and MES cells (fibroblasts and myofibroblasts) (Figure 2B) (Solovieva and Bronner, 2021). Thus, sympathoblasts have the potential to produce both neuronal and MES cell types during normal development, and recent studies suggest that SCPs can cross the MES-neuronal developmental boundary (Furlan et al, 2017).…”

Section: Ll Open Accessmentioning

confidence: 98%

Neuroblastoma: When differentiation goes awry

Zeineldin

Patel

Dyer

2022

Neuron

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“…Similarly, there is not much known about the heterogeneity of nerve-associated SCs themselves and how distinct the activation mechanisms for these cells would be. The SCPs that the SCs originate from can be of a distinct embryonic origin [ 17 ], and it is conceivable that the SCs in various anatomical locations are different. Influenced by the local tissue environment, these cells would respond to injury or disease onset differently.…”

Section: Discussionmentioning

confidence: 99%

“…The term SCP refers to a set of cell populations that form directly from NC cells or NC-derived boundary cap cells [ 17 ]. SCPs are distinct from the migrating NC cells and have a strong association with the axons.…”

Section: Origins Of the Pns Glial Cell Types And Their Functionsmentioning

confidence: 99%

Schwann Cells in Digestive System Disorders

Goluba

Kunrade

Riekstiņa

et al. 2022

Cells

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Proper functioning of the digestive system is ensured by coordinated action of the central and peripheral nervous systems (PNS). Peripheral innervation of the digestive system can be viewed as intrinsic and extrinsic. The intrinsic portion is mainly composed of the neurons and glia of the enteric nervous system (ENS), while the extrinsic part is formed by sympathetic, parasympathetic, and sensory branches of the PNS. Glial cells are a crucial component of digestive tract innervation, and a great deal of research evidence highlights the important status of ENS glia in health and disease. In this review, we shift the focus a bit and discuss the functions of Schwann cells (SCs), the glial cells of the extrinsic innervation of the digestive system. For more context, we also provide information on the basic findings regarding the function of innervation in disorders of the digestive organs. We find diverse SC roles described particularly in the mouth, the pancreas, and the intestine. We note that most of the scientific evidence concerns the involvement of SCs in cancer progression and pain, but some research identifies stem cell functions and potential for regenerative medicine.

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Schwann cell precursors: Where they come from and where they go

Cited by 18 publications

References 68 publications

Cell Fate Decisions in the Neural Crest, from Pigment Cell to Neural Development

Cell Fate Decisions in the Neural Crest, from Pigment Cell to Neural Development

Neuroblastoma: When differentiation goes awry

Schwann Cells in Digestive System Disorders

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