Schwann cells of the olfactory nerves contain glial fibrillary acidic protein and resemble astrocytes

Barber, P. C.; Lindsay, Ronald M.

doi:10.1016/0306-4522(82)90231-7

Cited by 243 publications

(160 citation statements)

References 23 publications

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“…1E8 appeared to immunostain the majority of olfactory nerve glia, but we cannot rule out the possibility that a small subpopulation of glia within the olfactory nerve is not immunostained by 1E8. In fact, electron microscopic and immunocytochemical experiments suggest that olfactory nerves may contain more than one glial cell type within the olfactory nerve (Barber and Lindsay, 1982;Pixley, 1992).…”

Section: Discussionmentioning

confidence: 99%

Development of olfactory nerve glia defined by a monoclonal antibody specific for schwann cells

Norgren

Ratner

Brackenbury

1992

Developmental Dynamics

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Although there is considerable interest in the possible role of olfactory glia in the pathfinding abilities of olfactory nerve axons, the complete development of these glia in vivo has not been described. Using a specific Schwann cell marker, the 1E8 antibody, we have found that olfactory nerve glia can be identified throughout development. These glia appear to originate in the olfactory placode and migrate initially into the periphery of the olfactory nerve, and later into the center of the nerve. Olfactory nerve glia enter the presumptive olfactory bulb with the olfactory receptor neuron axons and distribute themselves along the edge of the olfactory nerve layer. The fact that olfactory nerve glia are specifically immunostained by the lE8 monoclonal antibody, which recognizes the Schwann cell-specific protein Po, suggests that these cells more closely resemble Schwann cells than astrocytes or enteric glia. These results support and extend previous findings suggesting that olfactory nerve glia have distinctive developmental and anatomical features which may be important to the regenerative capacity of the olfactory system. 0 1992 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Development of olfactory nerve glia defined by a monoclonal antibody specific for schwann cells

Norgren

Ratner

Brackenbury

1992

Developmental Dynamics

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“…Glial processes in the sections were labeled with the lectin lycopersicon, which recognizes N-linked glycoproteins. The sequence shows the gradual increase in glial As is the case for their vertebrate counterparts (Kreutzberg and Gross, 1977;Doucette, 1984;Barber and Lindsay, 1982), olfactory receptor axons in the moth are small-diameter (0.1-0.2 µm) unmyelinated axons. In the mature nerve, these glial processes typically envelope groups of 50-80 axons.…”

Section: Development Of the Glial Network In The Antennal Nervementioning

confidence: 85%

“…The axonal bundles coursing along the mature antennal nerve are ensheathed by the processes of the peripherally derived AN glial cells, though we do not know to how many bundles a single glial cell might contribute. The glia enwrap bundles of 50-80 small-diameter axons, giving the antennal nerve a cross-sectional appearance similar to that of the olfactory nerve in vertebrates (Kreutzberg and Gross, 1977;Doucette, 1984;Barber and Lindsay, 1982;Burd, 1991). This pattern of glial ensheathment of bundles of small-diameter axons is also seen in the vertebrate central nervous system, for example in the cerebellar array of parallel fibers (Peters et al, 1991) and in Lissauer's tract in the spinal cord (Chung and Coggeshall, 1977).…”

Section: Network Formationmentioning

confidence: 99%

“…The final spatial distribution of the peripherally derived glial cells in the M. sexta olfactory pathway is well understood , the morphological organization of the nerve vis-à-vis axonal bundling closely resembling the vertebrate olfactory nerve (Kreutzberg and Gross, 1977;Doucette, 1984;Barber and Lindsay, 1982). Although our approach includes examination of network development using several markers in fixed tissue, a major objective was to probe the intact nerve electrophysiologically in order to examine glial-neuronal interactions in the three-dimensional and signaling context characteristic of the normal environment.…”

Section: Introductionmentioning

confidence: 99%

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Development of a glial network in the olfactory nerve: role of calcium and neuronal activity

2010

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In adult olfactory nerves of mammals and moths, a network of glial cells ensheathes small bundles of olfactory receptor axons. In the developing antennal nerve (AN) of the moth Manduca sexta, the axons of olfactory receptor neurons (ORNs) migrate from the olfactory sensory epithelium toward the antennal lobe. Here we explore developmental interactions between ORN axons and AN glial cells. During early stages in AN glial-cell migration, glial cells are highly dye coupled, dividing glia are readily found in the nerve and AN glial cells label strongly for glutamine synthetase. By the end of this period, dye-coupling is rare, glial proliferation has ceased, glutamine synthetase labeling is absent, and glial processes have begun to extend to enwrap bundles of axons, a process that continues throughout the remainder of metamorphic development. Whole-cell and perforated-patch recordings in vivo from AN glia at different stages of network formation revealed two potassium currents and an R-like calcium current. Chronic in vivo exposure to the R-type channel blocker SNX-482 halted or greatly reduced AN glial migration. Chronically blocking spontaneous Na-dependent activity by injection of tetrodotoxin reduced the glial calcium current implicating an activity-dependent interaction between ORNs and glial cells in the development of glial calcium currents.

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“…OECs express a curious mixture of astrocyte-specific and Schwann cell-specific phenotypic features (Doucette, 1990(Doucette, , 1995RamonCueto and Valverde, 1995;Franklin and Barnett, 1997; Ramon-Cueto and Franklin, 2002a) and have been reported to perform the roles of both astrocytes and Schwann cells (Doucette, 1990(Doucette, , 1993Doucette and Devon, 1993). For example, they contribute to the formation of the glia limitans of the olfactory bulb (Berger, 1971;Barber and Lindsay, 1982;Doucette, 1984Doucette, , 1990Doucette, , 1993Valverde and Lopez-Mascaraque, 1991), a role that elsewhere in the mammalian CNS is the exclusive domain of astrocytes (Peters et al, 1990). They also have the ability to assemble a PNStype myelin sheath around nerve fibers in vitro (Devon and Doucette, 1992Doucette, , 1995 as well as in vivo (Franklin et al, 1996;Imaizumi et al, 1998;Smith et al, 2002), thus being induced by axons to express a phenotype more like that of Schwann cells.…”

Section: Oecs Normally Differentiate Into Nonmyelinating Gliamentioning

confidence: 99%

Olfactory ensheathing cells: Historical perspective and therapeutic potential

Boyd

Skihar²,

Kawaja³

et al. 2003

The Anatomical Record Part B

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Schwann cells of the olfactory nerves contain glial fibrillary acidic protein and resemble astrocytes

Cited by 243 publications

References 23 publications

Development of olfactory nerve glia defined by a monoclonal antibody specific for schwann cells

Development of olfactory nerve glia defined by a monoclonal antibody specific for schwann cells

Development of a glial network in the olfactory nerve: role of calcium and neuronal activity

Olfactory ensheathing cells: Historical perspective and therapeutic potential

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