Schwellk�rper am Septum nasi

Wustrow, F

doi:10.1007/bf00523536

Cited by 32 publications

(13 citation statements)

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“…A slight increase with age of samples almost completely lacking subepithelial glands tendentially confirms the findings of Wustrow (1951) and Janzen (1986) who described atrophy of subepithelial glands in the elderly, but this is not very conclusive.…”

Section: Discussionsupporting

confidence: 85%

“…Till the age of 16-18 years, resistance declines to an adult value and shows only a slow decline with increasing age (Eccles 2000). While changes from child to adult seem to be dependent on growth, further decline of resistance seems to depend on atrophy of the mucosa, the submucosal glands, the cavernous tissue and the bones of the turbinates (Wustrow 1951;Janzen 1986). The complete restoration of the pseudostratified ciliated epithelial layer after laryngectomy even in the senium implicates the importance of effects triggered by the inhaled air.…”

Section: High Incidence Of Squamous Metaplasiamentioning

confidence: 96%

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Histological evaluation of age-related changes in human respiratory mucosa of the middle turbinate

Schrödter

Biermann

Halata

2003

Anatomy and Embryology

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Though the lining of the healthy human nose is subject of numerous investigations, age-related changes have attracted little attention. Furthermore, varying sampling sites complicate the evaluation of the available information. Reference is needed for evaluation of abnormal conditions, e.g. in persons with sleep apnea. Biopsy samples from the middle turbinate of 40 healthy humans aged 5 to 75 years were examined. Tissue samples were fixed immediately in glutaraldehyde and embedded in Epon for semi-thin sectioning and blind histological evaluation. In all age groups, patchy arrangement of different epithelial types were found. Ciliated epithelium decrease with age. Stratified and atrophic epithelial types show striking changes. Thin atrophic epithelium with conspicuously thickened basement membranes is only seen above the age of 40 years and is frequently found in older subjects. Stratified epithelial types initially increase with age, but decrease above 50 years. In the middle aged group (26 to 50 years) we found a remarkably high amount of squamous metaplasia, resulting in overall thicker epithelium becoming thinner in older subjects. In contrast, basement membranes are thinnest in the middle aged group. In conclusion, evaluating the histology of nasal respiratory epithelium must take pronounced age-related physiological changes into account.

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Section: Discussionsupporting

confidence: 85%

Section: High Incidence Of Squamous Metaplasiamentioning

confidence: 96%

Histological evaluation of age-related changes in human respiratory mucosa of the middle turbinate

Schrödter

Biermann

Halata

2003

Anatomy and Embryology

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“… 1 This has been further defined more recently. 2–3 Although a relationship between anterior septal thickness and nasal resistance has been suggested 4 it is not certain if the anterior septal intumescence contributes significantly to nasal obstruction. Although nasal surgery for airway resistance is usually based on subjective symptoms and a clinical assessment of the anatomical appearance and airway, there is poor or at best contradictory evidence to suggest that these correlate well with objective methods of assessing the nasal airway.…”

mentioning

confidence: 99%

Parameters of nasal airway anatomy on magnetic resonance imaging correlate poorly with subjective symptoms of nasal patency

1999

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Forty-four patients undergoing magnetic resonance imaging (MRI) head scans for non-nasal disease were asked to complete a questionnaire immediately after the scan. Subjective patency was scored for each nasal airway, patients were also asked about other nasal symptoms, hay fever, upper respiratory tract infections, medication and any history of nasal surgery or trauma. The following measurements from MRI scans were made: the cross-sectional area of the nasal airway at the anterior end of the middle turbinate, the horizontal width of the inferior turbinate and maximum septal mucosal thickness. In addition the presence of any septal deviation and the thickness or the mucosa of the paranasal sinuses was assessed. Correlation between subjective airway patency and the anatomical parameters studied was generally very weak. However, patients with sinus mucosal thickening on MRI scanning had significantly lower subjective patency scores (left P = 0.003, right P = 0.029) for both nasal airways. Assessment of the nasal airway on MRI correlates poorly with symptoms of nasal obstruction. However, patients with sinus mucosal thickening (> 5 mm) had significantly more symptoms of nasal obstruction on both sides.

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“…Further decline of resistance seems to depend on atrophy of the mucosa, the submucosal glands, the cavernous tissue and the turbinate bones [9,10]. Elderly patients have atrophic changes [11] and damage to the subepithelial capillaries [12,13] of the nasal mucosa, resulting in lower blood flow. Lower resistance may decrease the tightness of contact between the endoscope and the nasal mucosa.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for nasal bleeding in patients undergoing transnasal gastrointestinal endoscopy

Mieda

Miyashita

Osawa

et al. 2018

The Kaohsiung J of Med Scie

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Transnasal endoscopy is widely used in screening for upper gastrointestinal lesions because of less associated pain. Nasal bleeding is the most severe adverse effect, but specific risk factors have not been identified. The aim of this study is to identify risk factors for nasal bleeding during transnasal endoscopy. Nasal bleeding occurred in 160/3035 (5.3%) of patients undergoing transnasal endoscopy as part of health checkups. Patient data were retrospectively evaluated including anthropometric, medical, and life-style parameters with multiple logistic regression analysis. Multiple logistic regression revealed that nasal bleeding was significantly associated with age in decades [odds ratio/10 years 0.78, 95% confidence interval (CI) 0.63-0.97, p = 0.027], female gender (2.15, 95% CI 1.48-3.12, p < 0.001), a history of previous upper gastrointestinal endoscopy (0.55, 95% CI 0.36-0.82, p = 0.004), and chronic/allergic rhinitis (0.60, 95% CI 0.36-0.98, p = 0.043). Other factors including the use of antiplatelet and/or anticoagulant drugs were not significantly associated with nasal bleeding. Female and young patients are significantly associated with an increased risk of bleeding from transnasal endoscopy, but antiplatelet and/or anticoagulant medications and a history of chronic/allergic rhinitis may not be associated.

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Schwellk�rper am Septum nasi

Cited by 32 publications

References 0 publications

Histological evaluation of age-related changes in human respiratory mucosa of the middle turbinate

Histological evaluation of age-related changes in human respiratory mucosa of the middle turbinate

Parameters of nasal airway anatomy on magnetic resonance imaging correlate poorly with subjective symptoms of nasal patency

Risk factors for nasal bleeding in patients undergoing transnasal gastrointestinal endoscopy

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