Scientific instruments such as telescopes and distillation columns have played a prominent role in the history of science, but the key material of which these instruments were made has received scant attention. Focusing on the glass used to make scientific instruments and on the supply chains on which its production relied-allows us to see that "glass" covers a variety of materials and that the nature of glass depends on the material knowledge and environmental expertise invested in its manufacture. Between the seventeenth and the twentieth centuries, glassware moved back and forth between a dependence on processing locally sourced materials and reusing household items and a reliance on intraregional supply chains of specialty materials. G alileo's telescope is an iconic scientific instrument, and the telescopic discoveries he published in Sidereus Nuncius are arguably among the most famous episodes in the history of science. Yet the material of which Galileo's telescope lenses were made has remained remarkably invisible to historians of science. To see this optical glass, and the materials and the knowledge invested in its production, we need to turn our attention from this epoch-making book to the astronomer's shopping list. (See Figure 1.)In the autumn of 1609, Galileo jotted down on the back of a letter a list of items that he wished to buy on a shopping trip to Venice. 1 This list includes soap, oranges, sugar and spices, raisins, rice, slippers, and a small hat for his son Vincenzo, as well as more technical items such as German ground glass, pieces of mirror, and tripoli-and an address where these things might be found: the mirror-maker shop at the Sign of the King. Clearly, Galileo hoped to equip his optical workshop with the material substances, tools, and abrasives he needed to improve his telescope lenses. Venice was the ideal place to buy such things: the nearby island of Murano was home to the world's center of luxury glass production, and Venetian mirrors, made of cristallo glass, were widely acclaimed as the best. Galileo's shopping list reveals his knowledge of the quality of glass materials and the way in which mirrors were manufactured. Glass made according to the "German" method, which produced flat sheets by cutting and reheating a cylinder of glass, was preferable to glass made by the crown method, which resulted in much less even, irregular pieces. Galileo ground his lenses starting