Science and religion are influential social forces, and their interplay has been subject to many public and scholarly debates. The present article addresses how people mentally conceptualize the relationship between science and religion and how these conceptualizations can be systematized. To that end, we provide a comprehensive, integrative review of the pertinent literature. Moreover, we discuss how cognitive (in particular, epistemic beliefs) and motivational factors (in particular, epistemic needs, identity, and moral beliefs), as well as personality and contextual factors (e.g., rearing practices and cross-cultural exposure), are related to these mental conceptualizations. And finally, we provide a flowchart detailing the psychological processes leading to these mental conceptualizations. A comprehensive understanding of how individuals perceive the science-religion relationship is interesting in and of itself and practically relevant for managing societal challenges, such as science denial