Scientific Evidences of Calorie Restriction and Intermittent Fasting for Neuroprotection in Traumatic Brain Injury Animal Models: A Review of the Literature

Yang, Xu; Liu, Zejie; Xu, Shuting; Li, Chengxian; Li, Manrui; Cao, Shuqiang; Sun, Yuhui; Dai, Hao; Guo, Yadong; Chen, Xiameng; Liang, Weibo

doi:10.3390/nu14071431

Cited by 10 publications

(11 citation statements)

References 98 publications

(113 reference statements)

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“…Thus, autophagy activation is recently emerging as a hot topic to study neuroprotective mechanisms in chronic retinal neurodegenerative disorders (Kaarniranta et al, 2022). Similarly, given the parallelism between traumatic and chronic degenerative conditions, the activation of autophagy in the course of traumatic CNS injury is thought to produce a strong activation to elicit functional and anatomical recovery (Movahedpour et al, 2022;Zhang et al, 2022;Filippone et al, 2022;Xu et al, 2022;Kanno et al, 2022). This is partly based on the induction of stem cells (Xu et al, 2021;Maiti et al, 2019;Ceccariglia et al, 2020;Hwang et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Combined pulses of light and sound in the retina with nutraceuticals may enhance the recovery of foveal holes

Pinelli¹,

Berti²,

Scaffidi³

et al. 2022

Archives Italiennes De Biologie

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The present manuscript stems from evidence, which indicates that specific wavelength produce an activation of the autophagy pathway in the retina. These effects were recently reported to synergize with the autophagy-inducing properties of specific phytochemicals. The combined administration of photo-modulation and phytochemicals was recently shown to have a strong potential in eliciting the recovery in the course of retinal degeneration and it was suggested as a non-invasive approach named "Lugano protocol" to treat age-related macular degeneration (AMD). Recent translational findings indicate that the protective role of autophagy may extend also to acute neuronal injuries including traumatic neuronal damage. At the same time, very recent investigations indicate that autophagy activation and retinal anatomical recovery may benefit from sound exposure. Therefore, in the present study, the anatomical rescue of a traumatic neuronal loss at macular level was investigated in a patient with idiopathic macular hole by using a combined approach of physical and chemical non-invasive treatments. In detail, light exposure was administered in combination with sound pulses to the affected retina. This treatment was supplemented by phytochemicals known to act as autophagy inducers, which were administered orally for 6 months. This combined administration of light and sound with nutraceuticals reported here as Advanced Lugano's Protocol (ALP) produced a remarkable effect in the anatomical architecture of the retina affected by the macular hole. The anatomical recovery was almost complete at roughly one year after diagnosis and beginning of treatment. The structural healing of the macular hole was concomitant with a strong improvement of visual acuity and the disappearance of metamorphopsia. The present findings are discussed in the light of a synergism shown at neuronal level between light and sound in the presence of phytochemicals to stimulate autophagy and promote proliferation and neuronal differentiation of retinal stem cells.

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Section: Introductionmentioning

confidence: 99%

Combined pulses of light and sound in the retina with nutraceuticals may enhance the recovery of foveal holes

Pinelli¹,

Berti²,

Scaffidi³

et al. 2022

Archives Italiennes De Biologie

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“…4.1 Nutritional strategies: Fasting, phytochemicals, phytomelatonin, and fermented food 4.1.1 Fasting Fasting is an effective way to recover mitochondrial efficiency, and multiple human studies have shown its ability to restore metabolic pathways in people suffering from chronic pathologies. Fasting regimens are promising primary and secondary prevention strategies in patients suffering from metabolic and cardiovascular diseases (Oliveira et al, 2022;Papakonstantinou et al, 2022;Vasim et al, 2022;Zang et al, 2022), pain, inflammation and immune conditions (Feng et al, 2022;Fitzgerald et al, 2022;Parveen and Alhazmi, 2022), cancer (Lv et al, 2014;Marinac et al, 2016;Taucher et al, 2022;Tiwari et al, 2022), and neurological diseases characterized by altered mood, sleep, pain, and cognition (Phillips, 2019;Brocchi et al, 2022;Caron et al, 2022;Feng et al, 2022;Lobo et al, 2022;Xu et al, 2022).…”

Section: Figurementioning

confidence: 99%

Mitochondria: It is all about energy

et al. 2023

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Mitochondria play a key role in both health and disease. Their function is not limited to energy production but serves multiple mechanisms varying from iron and calcium homeostasis to the production of hormones and neurotransmitters, such as melatonin. They enable and influence communication at all physical levels through interaction with other organelles, the nucleus, and the outside environment. The literature suggests crosstalk mechanisms between mitochondria and circadian clocks, the gut microbiota, and the immune system. They might even be the hub supporting and integrating activity across all these domains. Hence, they might be the (missing) link in both health and disease. Mitochondrial dysfunction is related to metabolic syndrome, neuronal diseases, cancer, cardiovascular and infectious diseases, and inflammatory disorders. In this regard, diseases such as cancer, Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis (ALS), chronic fatigue syndrome (CFS), and chronic pain are discussed. This review focuses on understanding the mitochondrial mechanisms of action that allow for the maintenance of mitochondrial health and the pathways toward dysregulated mechanisms. Although mitochondria have allowed us to adapt to changes over the course of evolution, in turn, evolution has shaped mitochondria. Each evolution-based intervention influences mitochondria in its own way. The use of physiological stress triggers tolerance to the stressor, achieving adaptability and resistance. This review describes strategies that could recover mitochondrial functioning in multiple diseases, providing a comprehensive, root-cause-focused, integrative approach to recovering health and treating people suffering from chronic diseases.

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“…There is a strong consensus in that IF and CR promote AHN; for example by increasing the number of immature neuroblasts (Dias et al, 2021), increasing the survival of neuronal precursor cells and their differentiation into mature neurons (Lee et al, 2002;Levenson and Rich, 2007;Kaptan et al, 2015;Baik et al, 2020); boost the number of shuttle shaped cells in the subgranular zone, the cell density in CA3 and the number of neurons and glia (Bondolfi et al, 2004;Liu et al, 2017;Mana et al, 2017;Cao et al, 2022;Xu et al, 2022). Only one study evidenced a decreased number of new hippocampal neurons in response to IF (Setel et al, 2022).…”

Section: Caloric Restriction and Intermittent Fastingmentioning

confidence: 99%

“…Several studies highlighted that IF and CR dependent neurogenesis is linked with increased expression of hippocampal NPY (Singh et al, 2015;Cao et al, 2022;Xu et al, 2022) and depends on increased quantities of hippocampal acyl-ghrelin (Kim et al, 2015;Hornsby et al, 2016) and ghrelin receptor (Hornsby et al, 2016). Notably, IF and CR also induced a CREB-dependent increase in SIRT1 and SIRT3 (Pani, 2015;Liu et al, 2019;Baik et al, 2020;Landry and Huang, 2021).…”

Section: Caloric Restriction and Intermittent Fastingmentioning

confidence: 99%

Nutrition and adult neurogenesis in the hippocampus: Does what you eat help you remember?

et al. 2023

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Neurogenesis is a complex process by which neural progenitor cells (NPCs)/neural stem cells (NSCs) proliferate and differentiate into new neurons and other brain cells. In adulthood, the hippocampus is one of the areas with more neurogenesis activity, which is involved in the modulation of both emotional and cognitive hippocampal functions. This complex process is affected by many intrinsic and extrinsic factors, including nutrition. In this regard, preclinical studies performed in rats and mice demonstrate that high fats and/or sugars diets have a negative effect on adult hippocampal neurogenesis (AHN). In contrast, diets enriched with bioactive compounds, such as polyunsaturated fatty acids and polyphenols, as well as intermittent fasting or caloric restriction, can induce AHN. Interestingly, there is also growing evidence demonstrating that offspring AHN can be affected by maternal nutrition in the perinatal period. Therefore, nutritional interventions from early stages and throughout life are a promising perspective to alleviate neurodegenerative diseases by stimulating neurogenesis. The underlying mechanisms by which nutrients and dietary factors affect AHN are still being studied. Interestingly, recent evidence suggests that additional peripheral mediators may be involved. In this sense, the microbiota-gut-brain axis mediates bidirectional communication between the gut and the brain and could act as a link between nutritional factors and AHN. The aim of this mini-review is to summarize, the most recent findings related to the influence of nutrition and diet in the modulation of AHN. The importance of maternal nutrition in the AHN of the offspring and the role of the microbiota-gut-brain axis in the nutrition-neurogenesis relationship have also been included.

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Scientific Evidences of Calorie Restriction and Intermittent Fasting for Neuroprotection in Traumatic Brain Injury Animal Models: A Review of the Literature

Cited by 10 publications

References 98 publications

Combined pulses of light and sound in the retina with nutraceuticals may enhance the recovery of foveal holes

Combined pulses of light and sound in the retina with nutraceuticals may enhance the recovery of foveal holes

Mitochondria: It is all about energy

Nutrition and adult neurogenesis in the hippocampus: Does what you eat help you remember?

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