Scientific Opinion on Flavouring Group Evaluation 203, Revision 2 (FGE.203Rev2): α,β‐unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.4 of FGE.19 with two or more conjugated double‐bonds and with or without additional non‐conjugated double‐bonds

Abstract

.057] was also tested in an in vivo gene mutation assay giving negative results. Both hexa-2(trans),4(trans)-dienal .057] and deca-2(trans),4(trans)-dienal .140] were tested in vivo for the induction of micronuclei in rats bone marrow and peripheral reticulocytes after oral or intraperitoneal administration. None of the two substances induced increased frequencies of micronuclei. The Panel concluded that the concern for genotoxicity can be ruled out for the representative substances hexa-2(trans),4(trans)-dienal .057] and deca-2(trans),4(trans)-dienal .140] and therefore also for the other substances in this group 02.153, 02.162, 02.188, 05.064,

Safety and efficacy of 26 compounds belonging to chemical group 3 (α,β‐unsaturated straight‐chain and branched‐chain aliphatic primary alcohols, aldehydes, acids and esters) when used as flavourings for all animal species and categories

“… secondary components: mixture of the ( cis, cis )‐, ( cis, trans )‐ and ( trans, cis )‐2,4‐decadienals (sum of all isomers 95%); acetone and isopropanol (EFSA CEF Panel, ). …”

“… at least 92% (predominantly E,E ); secondary components 2–4% ( E,Z )‐2,4‐heptadienal and 2–4% 2,4‐heptadienoic acid (EFSA CEF Panel, ). …”

“… secondary components: 4–5% deca‐2( trans ),4( cis )‐dienal, < 1% deca‐2( cis ),4( cis )‐dienal, < 0.5% deca‐2( cis ),4( trans )‐dienal and < 0.1% 2,4‐decadienoic acid (EFSA CEF Panel, ). …”

“…The remaining 26 compounds were excluded from the previous assessment because the EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) was not in the position to conclude on the genotoxicity of this group of compounds and expressed the need for additional data to complete the assessment (EFSA CEF Panel, ,b). Subsequently, the EFSA CEF Panel delivered two opinions on the 26 compounds, concluding that there are no genotoxicity concerns (EFSA CEF Panel, ; EFSA FAF Panel, ).…”

Safety and efficacy of eight compounds belonging to different chemical groups when used as flavourings for cats and dogs

“…For 2‐ethyl‐4‐hydroxy‐5‐methyl‐3(2 H )‐furanone [13.084], hexa‐2( trans ),4( trans )‐dienal [05.057] and tridec‐2‐enal [05.078], the EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) raised a concern for genotoxicity (EFSA, ; EFSA CEF Panel, ,b), which was ruled out based on the additional data submitted (EFSA CEF Panel, , , ; EFSA FAF Panel, ).…”