Scientific Opinion on the substantiation of health claims related to<i>Lactobacillus plantarum</i>299 (DSM 6595, 67B) (ID 1078) and decreasing potentially pathogenic intestinal microorganisms pursuant to Article 13(1) of Regulation (EC) No 1924/2006

Lactobacilli occupy a unique position in human culture and scientific history. Like brewer's and baker's yeast, lactobacilli have been associated with food production and preservation for thousands of years. species are used in mixed microbial cultures, such as the classical/ inoculum for yogurt fermentation, or combinations of diverse lactobacilli/yeasts in kefir grains. The association of lactobacilli consumption with greater longevity and improved health formed the basis for developing lactobacilli as probiotics, whose market has exploded worldwide in the past 10 years. The decade that followed the determination of the first genome sequence of a food-associated species, , saw the application to lactobacilli of a full range of functional genomics methods to identify the genes and gene products that govern their distinctive phenotypes and health associations. In this review, we will briefly remind the reader of the range of beneficial effects attributed to lactobacilli, and then explain the phylogenomic basis for the distribution of these traits across the genus. Recognizing the strain specificity of probiotic effects, we review studies of intraspecific genomic variation and their contributions to identifying probiotic traits. Finally we offer a perspective on classification of lactobacilli into new genera in a scheme that will make attributing probiotic properties to clades, taxa, and species more logical and more robust.

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Scientific Opinion on the substantiation of health claims related toLactobacillus plantarum299 (DSM 6595, 67B) (ID 1078) and decreasing potentially pathogenic intestinal microorganisms pursuant to Article 13(1) of Regulation (EC) No 1924/2006

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References 6 publications

The Genomic Basis of Lactobacilli as Health-Promoting Organisms

The Genomic Basis of Lactobacilli as Health-Promoting Organisms

The Genomic Basis of Lactobacilli as Health-Promoting Organisms

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