Scientific review on mosquitoes and mosquito‐borne diseases

Pages, Nitu; Huber, Karine; Cipriani, Micaela; Chevallier, Véronique; Conraths, Franz Josef; Goffredo, Maria; Balenghien, Thomas

doi:10.2903/sp.efsa.2009.en-7

Cited by 11 publications

(18 citation statements)

References 225 publications

(294 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Severe cases result in intoxication and hemorrhages leading to liver and kidney failure and may turn fatal. This disease is endemic in parts of Africa and enjoys the status of an epidemic in South America [18]. Yellow fever has its origin in tropical Africa [42] and later on invaded other parts of the world [43,44].…”

Section: Yellow Fevermentioning

confidence: 99%

“…The virus exhibits an animal-vector-human cycle and pigs acts as the major reservoir host [42,53]. In addition, there are few other members of Flavivirus group causing different neurological infections in different parts of the world such as the West Nile Fever, Rift Valley Fever, Eastern Equine Encephalitis, etc., all being transmitted by mosquitoes [18] and are not dealt in detail in this review, as this work intends to focus more on mosquito repellents.…”

Section: Japanese Encephalitismentioning

confidence: 99%

“…In the Mediterranean, Ae. aegypti acted as the major transmitting agent of dengue during the 19 th and 20 th centuries [18]. By the year 2000 and beyond the mosquito has been attained worldwide distribution [38].…”

Section: Denguementioning

confidence: 99%

“…Volume 8 ranks as an urban epidemic (Table 1) [18]. A new point mutation was identified from Chikungunya virus which confers the virus an increased fitness for infectivity, dissemination, and transmission in Ae.…”

mentioning

confidence: 99%

“…Chikungunya fever is characterized by sudden onset of fever followed by the appearance of rashes especially on the face, the trunk and the limbs followed by joint pain, the latter last for a long duration of time ranging from weeks to months together leading to chronic joint pain in several patients. The infection manifests in both endemic and epidemic forms and is a major epidemic in urban Asia [18].…”

mentioning

confidence: 99%

See 4 more Smart Citations

Evolution, Current Status and Prospects of Phyto-Repellents against Mosquitoes

Bhat¹,

Aravind

2017

IJPPE

View full text Add to dashboard Cite

Mosquitoes enjoy wide geographical distribution and act as vectors for diverse pathogenic organisms from viruses to protozoans. Mosquito-borne diseases have a long history with some of them like Malaria dominating the scene for centuries. New diseases like Dengue fever, Zika viral disease etc. get added to the list from time to time. Vector control is an effective and widely accepted strategy in the management of mosquito-borne diseases. Mosquito repellents are an important product range extensively used for the management of mosquito-borne diseases. The research and development activities on mosquito repellents of plant origin have been reviewed in this article and classified into three categories like research reports, patents and commercial products, based on their outcomes. The relevance of plant-based mosquito repellents is discussed with reference to current societal and market trends. The review has revealed an increasing trend among researchers towards product development and entry of effective and innovative products into the market. The market analysis reports also confirm competitive advantage for herbal repellents in the coming years.

show abstract

Section: Yellow Fevermentioning

confidence: 99%

Section: Japanese Encephalitismentioning

confidence: 99%

Section: Denguementioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Evolution, Current Status and Prospects of Phyto-Repellents against Mosquitoes

Bhat¹,

Aravind

2017

IJPPE

View full text Add to dashboard Cite

show abstract

Toxicity and possible mechanisms of action of honokiol from Magnolia denudata seeds against four mosquito species

Wang

Perumalsamy

Xue

et al. 2019

Sci Rep

View full text Add to dashboard Cite

This study was performed to determine the toxicity and possible mechanism of the larvicidal action of honokiol, extracted from Magnolia denudata seeds, and its 10 related compounds against third-instar larvae of insecticide-susceptible Culex pipiens pallens, Aedes aegypti, and Aedes albopictus and Anopheles sinensis resistant to deltamethrin and temephos. Honokiol (LC50, 6.13–7.37 mg/L) was highly effective against larvae of all of the four mosquito species, although the toxicity of the compound was lower than that of the synthetic larvicide temephos. Structure–activity relationship analyses indicated that electron donor and/or bulky groups at the ortho or para positions of the phenol were required for toxicity. Honokiol moderately inhibited acetylcholinesterase and caused a considerable increase in cyclic AMP levels, indicating that it might act on both acetylcholinesterase and octopaminergic receptors. Microscopy analysis clearly indicated that honokiol was mainly targeted to the midgut epithelium and anal gills, resulting in variably dramatic degenerative responses of the midgut through sequential epithelial disorganization. Honokiol did not affect the AeCS1 mRNA expression level in Ae. aegypti larvae, but did enhance expression of the genes encoding vacuolar-type H+-ATPase and aquaporin 4, indicating that it may disturb the Na+, Cl− and K+ co-transport systems. These results demonstrate that honokiol merits further study as a potential larvicide, with a specific target site, and as a lead molecule for the control of mosquito populations.

show abstract

Synthesis, toxicological and in silico evaluation of novel spiro pyrimidines against Culex pipiens L. referring to chitinase enzyme

Abbass,

Ali,

El-Farargy

et al. 2024

Sci Rep

View full text Add to dashboard Cite

The exponential development of resistance to conventional chemical insecticides adds another important motive for the creation of novel insecticidal active agents. One of the keys to meeting this challenge is the exploration of novel classes of insecticidal molecules with different modes of action. Herein, a novel series of spiro pyrimidine derivatives was prepared using some green synthetic methodologies such as microwave irradiation, and sonication under ultrasound waves. Spiro pyrimidine aminonitrile 1 is a key starting material for the synthesis of targets 2–9 by reaction with different carbon electrophiles and nitrogen nucleophiles. The structures of all the newly synthesized compounds were approved using spectral data. The toxicological efficiency and biological impacts of the synthesized spiro pyrimidine derivatives were assessed against Culex pipiens L. larvae. The toxicity of synthesized compounds showed remarkable variations against the C. pipiens larvae. Where, 3, 4 and 2 were the most efficient compounds with LC50 values of 12.43, 16.29 and 21.73 µg/mL, respectively. While 1 was the least potent compound with an LC50 value of 95.18 µg/mL. As well, other compounds were arranged according to LC50 values as follows 5 > 7 > 6 > 9 > 8. In addition, 3 and 4 exhibited significant prolongation of the developmental duration and greatly inhibited adult emergence. Moreover, many morphological deformities were observed in all developmental stages. Furthermore, cytotoxicity of the most effective compounds was assessed against the normal human cells (WI-38) as non-target organisms, where compounds 2, 4 and 3 showed weak to non-toxic effects. The study of binding affinity and correlation between chemical structure and reactivity was carried out using molecular docking study and DFT calculations to investigate their mode of action. This study shed light on promising compounds with larvicidal activity and biological impacts on the C. pipiens life cycle.

show abstract

Scientific review on mosquitoes and mosquito‐borne diseases

Cited by 11 publications

References 225 publications

Evolution, Current Status and Prospects of Phyto-Repellents against Mosquitoes

Evolution, Current Status and Prospects of Phyto-Repellents against Mosquitoes

Toxicity and possible mechanisms of action of honokiol from Magnolia denudata seeds against four mosquito species

Synthesis, toxicological and in silico evaluation of novel spiro pyrimidines against Culex pipiens L. referring to chitinase enzyme

Contact Info

Product

Resources

About