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Objective: To explore the complex relationship between metabolic syndrome (MetS) and musculoskeletal (MSK) disorders, highlighting the impact of MetS on bone and joint health, and to propose effective management strategies for improving patient outcomes. Methods: This comprehensive review involved an extensive literature search conducted on 17 September 2024, utilising scientific databases such as PubMed, Google Scholar, and Scopus. The search, focused on articles published in English and pertaining to humans, employed Boolean operators and MeSH terms ‘MSK’, ‘metabolic diseases’, ‘diabetes’ and ‘osteoporosis’. Results: MetS, characterised by obesity, inflammation, insulin resistance (IR), and hypertension, is closely associated with a variety of MSK disorders including osteoarthritis, osteoporosis, and tendinopathy, among others. These conditions exacerbate MetS symptoms, creating a feedback loop that complicates patient management. The review identifies both common and rare metabolic and genetic disorders contributing to MSK issues, emphasising the intricate interplay between metabolic dysfunctions and MSK health. Special attention is given to the MSK manifestations of prevalent metabolic diseases such as diabetes mellitus, gout, and osteoporosis, underscoring their significant impact on quality of life. Conclusion: Understanding the relationship between MetS and MSK disorders is crucial for the development of holistic management strategies. The review suggests that addressing the root metabolic issues alongside direct treatment of MSK symptoms can significantly improve patient outcomes. Future research should focus on integrated care approaches that offer hope and optimism for individuals facing these interconnected challenges.
Objective: To explore the complex relationship between metabolic syndrome (MetS) and musculoskeletal (MSK) disorders, highlighting the impact of MetS on bone and joint health, and to propose effective management strategies for improving patient outcomes. Methods: This comprehensive review involved an extensive literature search conducted on 17 September 2024, utilising scientific databases such as PubMed, Google Scholar, and Scopus. The search, focused on articles published in English and pertaining to humans, employed Boolean operators and MeSH terms ‘MSK’, ‘metabolic diseases’, ‘diabetes’ and ‘osteoporosis’. Results: MetS, characterised by obesity, inflammation, insulin resistance (IR), and hypertension, is closely associated with a variety of MSK disorders including osteoarthritis, osteoporosis, and tendinopathy, among others. These conditions exacerbate MetS symptoms, creating a feedback loop that complicates patient management. The review identifies both common and rare metabolic and genetic disorders contributing to MSK issues, emphasising the intricate interplay between metabolic dysfunctions and MSK health. Special attention is given to the MSK manifestations of prevalent metabolic diseases such as diabetes mellitus, gout, and osteoporosis, underscoring their significant impact on quality of life. Conclusion: Understanding the relationship between MetS and MSK disorders is crucial for the development of holistic management strategies. The review suggests that addressing the root metabolic issues alongside direct treatment of MSK symptoms can significantly improve patient outcomes. Future research should focus on integrated care approaches that offer hope and optimism for individuals facing these interconnected challenges.
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