Scientometric analysis of mTOR signaling pathway in liver disease

Abstract

Background: The mTOR pathway is vital for homeostasis, metabolism, cancer transplantation and regeneration in the liver. The aim of this study is to use a bibliometric method to reveal current research hotspots and promising future trends in mTOR signaling in liver diseases. Methods: Publications were searched and downloaded from the Web of Science Core Collection (WOSCC) Database. CiteSpace, Carrot2, and VOSviewer programs were utilized to analyze the contribution of various countries/regions, institutes, and authors; and to reveal research hotspots and promising future trends in this research area.Results: Until May 21, 2019, a total of 2,232 papers regarding mTOR signaling pathway in liver disease were included, and each paper was cited 23.21 times on average. The most active country was the USA. 5 landmark articles with centrality and burstiness were determined by co-citation analysis. Research hotspots included "liver transplantation" "hepatic stellate cell proliferation" "NAFLD" "therapy of HCC". Moreover, six key clusters were discovered during the procedure of "clustering", including "liver transplantation" "protein synthesis" "mTOR inhibitor" "following early cyclosporine withdrawal" "srebp-1 activation", and "hepatocellular cancer". Conclusions:Various scientific methods were applied to reveal scientific productivity, collaboration, and research hotspots in the mTOR signaling pathway in liver disease. Liver transplantation, hepatic stellate cell proliferation, non-alcoholic fatty liver disease (NAFLD), therapy of hepatocellular carcinoma (HCC), cell growth and autophagy, are research hotspots and are likely to be promising in the next few years. Further studies in this field are needed.

The global trends of migraine research from 2010 to 2019: a scientometric study

“…As it can quantify the growth of literature in specific subjects and the impact of individual research results, scientometrics is considered an ideal methodological choice for evaluating research trends (9)(10)(11)(12). Scientometrics has been widely used in various research fields (10)(11)(12)(13)(14). For example, scientometric analysis was used to analyze the knowledge base and emerging topics of drug liver injury in the past decade (11).…”

“…For example, scientometric analysis was used to analyze the knowledge base and emerging topics of drug liver injury in the past decade (11). Another study used scientometric methods to analyze the mTOR (mammalian target of rapamycin) signaling pathway in liver diseases (14). To our knowledge, scientometrics has not been applied to analyze the status and foci of global migraine research over the past decade.…”

Emerging Trends and Research on Hydroxychloroquine Treatment in Diseases From 1991 to 2020

“…It is an effective analysis tool of knowledge mapping combines theories and methods from mathematics, graphics, statistics and other disciplines to reveal the core structure, developmental history, hotspots, and integral knowledge architecture of a eld [15,16]. CiteSpace supports various types of bibliometric studies, including collaboration network analysis, co-word analysis, author co-citation analysis and document co-citation [17,18]. Until now, it has been continuously developed to meet the needs for visual analytic tasks and widely used in bibliometric analysis.…”

Some comments on using of Web of Science Core Collection for bibliometric studies in Ann Transl Med. Vol. 8

“…Using the methods noticed in the two articles by Fang et al (1) and Liang et al (2) with "front page" as a filter, 2,068 publications and 7,250 publications were found in each of the articles respectively in Table 1. As a result, 499 publications (24% of the 2,068 publications) and 2,239 publications (31% of the 7,250 publications) did not contain searching keywords in their "front page."…”