Scintigraphy of the salivary glands in Sjögen's syndrome.

Arrago, J. P.; Rain, J. D.; Brochériou, C; Rocher, François

doi:10.1136/jcp.40.12.1463

Cited by 38 publications

(15 citation statements)

References 14 publications

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“…Salivary scintigraphy is a readily available, minimally invasive diagnostic test used to evaluate salivary gland functions. It has been used in the diagnosis of a variety of salivary disorders [23, 24, 25]. Scintigraphy is a particularly valuable tool as it produces a dynamic, objective, and quantitative measurement of the major salivary gland functions, and allowed for differentiation of abnormalities in saliva production (UR) and secretion (ER) in our study.…”

Section: Discussionmentioning

confidence: 99%

Evidence for Decreased Salivary Function in Patients with Reflux Esophagitis

Kao

Ho²,

ChangLai³

et al. 1999

Digestion

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It has been speculated that impaired salivary flow contributes to abnormal acid clearance of the esophagus in gastroesophageal reflux and results in reflux esophagitis (RE). To test this hypothesis, salivary functions were measured by quantitative salivary scintigraphies in patients with RE and in age- and sex-matched controls for comparison. Nineteen patients with RE and 36 healthy volunteers were enrolled in the study. After an intravenous injection of 5 mCi Tc-99m pertechnetate, sequential images of 1 min/frame were acquired for 30 min. The 1- and 15-min uptake ratios (UR) of the tracer in the four major salivary glands over the backgrounds were calculated. Saliva excretion was stimulated by 1 tablet of 200 mg ascorbic acid given orally 15 min after injection of the tracer, then the maximal excretion ratios (ER) of the four major salivary glands were calculated for the sialagogue stimulation. RE patients had lower values of 1st and 15th min UR and maximal ER than controls in the 4 major salivary glands. Poor salivary functions which represented a decrease in both UR and ER for patients with RE have been confirmed by quantitative salivary scintigraphy in this study.

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Section: Discussionmentioning

confidence: 99%

Evidence for Decreased Salivary Function in Patients with Reflux Esophagitis

Kao

Ho²,

ChangLai³

et al. 1999

Digestion

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“…Third, there may be differences in the nature or the progression of the pathologic process in the 2 types of glands. Discrepancies between the parotid and submandibular glands were also reported in a study of their functions (17), in which scintigraphy of the salivary glands (using technetium-pertechnetate) showed more severe functional impairment of the submandibular glands than of the parotid glands in patients with S S . In their report of findings at autopsy, Waterhouse and Doniach suggested that the submandibular glands might be the most sensitive indicator of salivary gland involvement in SS (18).…”

Section: Discussionmentioning

confidence: 99%

Salivary gland echography in patients with sjögren's syndrome

Kawamura

Taniguchi

Itoh

et al. 1990

Arthritis & Rheumatism

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Ultrasonographic examinations of salivary glands were performed on 24 patients with Sjögren's syndrome. On B‐mode echographic images, the submandibular glands of 21 of the patients (88%) showed a heterogeneous pattern, whereas all of the control subjects had homogeneous patterns. This distinction was further confirmed by the results of the analysis of the histogram patterns of echo intensity and echo frequency of the submandibular glands, which showed that the width of the echo level at 0% and 10% of the maximum normalized frequency was significantly greater in patients with Sjögren's syndrome than in the control subjects. Similar histographic findings were present in the parotid glands, although the heterogeneous ultrasonographic pattern was observed in only 8 of the 24 patients (33%). These results indicate that ultrasonography may be useful in the evaluation of salivary gland involvement in patients with Sjögren's syndrome.

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“…Zur Objektivierung und Erfassung der Xerostomie, als Teil des dominierenden Sicca-Syndroms beim SS, kann eine Speicheldrüsenszintigraphie eingesetzt werden, welche eine funktionelle Messung und Beurteilung der Radionuklidaufnahme und -exkretion [2] ermöglicht. Mit der Sialographie, die bei schwieriger Gangsondierung technisch nicht immer möglich ist, kann das häufig rarefizierte Gangsystem der Speicheldrüsen dargestellt werden [12].…”

Section: Glandulärunclassified

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Ostendorf

Cohnen²,

Scherer³

2006

Z. Rheumatol.

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Guidelines and diagnostic algorithms for the introduction of diagnostic procedures for connective tissue diseases have not yet been established and standardized. Diagnosis is often based on the patients's typical history, clinical symptoms and specific laboratory profiles. The use of diagnostic imaging procedures is relevant for differential diagnosis, for the assessment of disease activity and organ involvement, for defining the prognosis and monitoring responses to therapy and side effects. Experience with these techniques and diagnostic procedures, their application, indications and analysis represent the platform for rational and optimal diagnosis as well of defined therapy stratification.

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Scintigraphy of the salivary glands in Sjögen's syndrome.

Cited by 38 publications

References 14 publications

Evidence for Decreased Salivary Function in Patients with Reflux Esophagitis

Evidence for Decreased Salivary Function in Patients with Reflux Esophagitis

Salivary gland echography in patients with sjögren's syndrome

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