Scintigraphy with 201Tl for detection of thyroid cancer metastases

Piers, Da; Sluiter, Wim J.; Willemse, Phb; Doorenbos, H

doi:10.1007/bf00257220

Cited by 12 publications

(1 citation statement)

References 12 publications

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“…In this series, there were no patients on thyroid medication. Some authors [17,18], however, have reported preferential radiothallium uptake in patients with thyroid carcinoma while on thyroid suppressive therapy. We have also noted such uptake, as well as accumulation in suppressed thyroid tissue, in patients with autonomous hyperfunctioning nodules, and in subacute thyroiditis.…”

Section: Discussionmentioning

confidence: 99%

Radiothallium scintigraphy in solitary nonfunctioning thyroid nodules

et al. 1984

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The role of radiothallium201Tl chloride scintigraphy was evaluated in 117 patients with solitary thyroid nodules, demonstrated as nonfunctioning with99mTc pertechnetate, and in which histologic diagnosis was obtained. The nodules were malignant in 25 patients and benign in 92. In an attempt to improve the initial diagnostic discrimination between malignant and benign lesions, the degree of accumulation of201Tl by the nodule was assessed semiquantiatively. The uptake was graded by comparing the accumulation by the nodule with that in the paranodular tissue (PN) (1‐absent; 2‐minimal uptake but lower than in PN; 3‐uptake equal to PN; 4‐mildly preferential uptake in comparison with PN; 5‐markedly increased uptake). None of the patients with grade 1 or grade 2 uptake had malignant disease. Of 25 patients with histologically confirmed cysts, 21 had uptake of grade 1 and 4 of grade 2. Benign adenomas (67 patients) were associated with all grades, 45% having grade 3 uptake. Uptake of201Tl in malignant lesions was in all instances at least equal to paranodular tissue or higher (grades 3–5). The incidence of malignancy was 17% in grade 3, 15% in grade 4, and 67% in grade 5 uptake. It is considered that thallium scintigraphy is not by itself a definitive investigation for thyroid cancer but, since the predictive value of malignancy with strict decision threshold (grades 1–4 considered normal and grade 5 abnormal) is 67%, and predictive value of a negative test is 90%, the procedure does have a useful role in investigation of nonfunctioning solitary thyroid nodules either by heightening the suspicion of malignancy or by indicating a very low probability of malignant change.

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Section: Discussionmentioning

confidence: 99%

Radiothallium scintigraphy in solitary nonfunctioning thyroid nodules

et al. 1984

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Early and delayed thallium 201 imaging diagnosis of patients with cold thyroid nodules

Bleichrodt

Vermey

Piers³

et al. 1987

Cancer

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Thallous chloride uptake and DNA profile in parathyroid adenomas

Carlson

Farndon

Shenton

et al. 1990

Journal of British Surgery

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Thallium isotope scintigraphy is used to localize parathyroid adenomas but the mechanism underlying the technique is poorly understood. While larger adenomas are reliably localized the results are less certain for small tumours. This study explores the relationship between cellular DNA profile and thallium uptake (localization accuracy) in 24 parathyroid adenomas. The DNA profile was assessed using flow cytometry and standard subtraction thallium scintigraphy was performed before surgery. Fifteen of the 24 adenomas demonstrated excessive mitotic activity and 13 of these glands were accurately localized. Of the remaining nine glands, only five were localized accurately (P less than 0.01, chi 2 test including Yates' correction). This difference in thallium uptake could not be accounted for on the basis of gland weight. Thallium localization of parathyroid adenomas is related to mitotic activity. This may explain some of the limitations of this technique.

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Scintigraphy with 201Tl for detection of thyroid cancer metastases

Cited by 12 publications

References 12 publications

Radiothallium scintigraphy in solitary nonfunctioning thyroid nodules

Radiothallium scintigraphy in solitary nonfunctioning thyroid nodules

Early and delayed thallium 201 imaging diagnosis of patients with cold thyroid nodules

Thallous chloride uptake and DNA profile in parathyroid adenomas

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