Scirrhous carcinoma of the stomach: A clinical and pathological study of 106 surgical cases

Abstract

Clinical and pathological characteristics of scirrhous carcinoma of the stomach were studied in 106 cases treated by gastrectomy between 1973 and 1983. The male to female ratio was 0.58. The percentage of scirrhous carcinomas to all gastric carcinomas resected in the same period was three times higher in females than males. The age distribution of the patients suggested that there were two peaks in the forties and sixties in the male, and in the thirties and fifties in the female. The incidence of scirrhous carcinoma in all types of gastric carcinoma was significantly higher in the twenties, thirties and forties compared to the lowest incidence in the seventies. In the female group the primary lesion had a tendency to be adjacent to the fundic gland area and to avoid intestinal metaplasia. In the male the opposite was recognized. Cancer nests with single cells or only several cells were common in this type of carcinoma. These findings suggest that there might be two biologically different scirrhous carcinomas both in the male and the female, the appearance of single carcinoma cells might be favored by female sex hormones and young ages, and not only the original gastric mucosa but also mucosa with intestinal metaplasia could be precursors of single carcinoma cells.

Clinicopathological Analysis of Borrmann Type IV Gastric Cancer

“…We found that 9% of patients with gastric cancers had Borrmann type IV gastric cancer, an incidence rate similar to that observed in other studies (1,5,8,9). We also found that the mean age of patients with Borrmann type IV gastric cancer was similar to that of all gastric cancer patients in Korea (8).…”

“…The clinical characteristics of Borrmann type IV gastric cancer include a high rate of incidence in young females (1,2,5), delayed diagnosis and detection at an advanced stage (1,2,5～7), peritoneal dissemination at the first operation (1), many peritoneal recurrences after a curative resection (1～3), low hepatic metastasis (1,2) and a low curative resection rate (2). Difficulties in treating this type of tumor may be due to both these specific characteristics and the late diagnosis.…”

The novel long noncoding RNA RP11–357H14.17 acts as an oncogene by promoting cell proliferation and invasion in diffuse-type gastric cancer

“…Despite recent advances in surgical techniques and the medical treatment of DGC, the prognosis of patients with DGC remains relatively poor, in the absence of reliable early diagnostic markers and therapeutic targets for the suppression of tumor metastasis 4–6. The 5-year survival rate remains low 7–9. DGC has poorer prognosis, and occurs more frequently in younger individuals with GC 10,11.…”

Extended surgery—Left upper abdominal exenteration plus Appleby's method—For type 4 gastric carcinoma

“…Because scirrhous cancer cannot be diagnosed in its early stage, almost all tumors are large (>10 cm) and involve the serosa when finally detected (2,3). Some investigators have proposed that scirrhous cancer should not be treated surgically (4).…”