Sclareol exerts synergistic antidepressant effects with quercetin and caffeine, possibly suppressing GABAergic transmission in chicks

Kamli, Hossam; Shaikh, Ahmad; Bappi, Mehedi Hasan; Raposo, António; Ahmad, Md Faruque; Sonia, Fatema Akter; Akbor, Md. Showkoth; Prottay, Abdullah Al Shamsh; Gonçalves, Sheila Alves; Araújo, Isaac Moura; Coutinho, Henrique Douglas Melo; Elbendary, Ehab Y.; Lho, Linda Heejung; Han, Heesup; Islam, Muhammad Torequl

doi:10.1016/j.biopha.2023.115768

Cited by 5 publications

(1 citation statement)

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“…COX-1 contains four helices and 513 amino acid residues, while COX-2 contains 16 helices and 227 amino acid residues. Their 3D crystal structure validity was rechecked by procheack ( Kamli et al, 2023 ).…”

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory activity of d-pinitol possibly through inhibiting COX-2 enzyme: in vivo and in silico studies

Haque,

El-Nashar,

Akbor

et al. 2024

Front. Chem.

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Introduction: D-pinitol, a naturally occurring inositol, has diverse biological activities like antioxidant, antimicrobial and anticancer activities. This study aimed to evaluate anti-inflammatory effect of d-pinitol in a chick model. Additionally, in silico studies were performed to evaluate the molecular interactions with cyclooxygenase-2 (COX-2).Methods: The tested groups received d-pinitol (12.5, 25, and 50 mg/kg) and the standard drugs celecoxib and ketoprofen (42 mg/kg) via oral gavage prior to formalin injection. Then, the number of licks was counted for the first 10 min, and the paw edema diameter was measured at 60, 90, and 120 min.Results and Discussion: The d-pinitol groups significantly (p < 0.05) reduced the number of paw licks and paw edema diameters, compared to negative control. When d-pinitol was combined with celecoxib, it reduced inflammatory parameters more effectively than the individual groups. The in silico study showed a promising binding capacity of d-pinitol with COX-2. Taken together, d-pinitol exerted anti-inflammatory effects in a dose-dependent manner, possibly through COX-2 interaction pathway.

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Section: Resultsmentioning

confidence: 99%