Sclera to the Rescue in the Covid-19 Pandemic- Therapeutic Scleral Grafting in Perforated Corneal Ulcers due to Donor Cornea Shortage

Natarajan, Radhika; Matai, Hiren; Narayanan, Niveditha

doi:10.46527/2582-5038.178

Cited by 1 publication

(1 citation statement)

References 7 publications

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“…Keratoplasty in corneal thinning and perforation Corneal thinning and perforation may result in permanent vision loss, and immediate surgical intervention is needed to prevent catastrophic consequences such as endophthalmitis [12] . Temporary therapies for this situation including corneal gluing [13][14][15] , bandage contact lenses [16][17][18][19] , amniotic membrane transplantation [20][21][22] , scleral graft, and conjunctival flap [23][24][25][26] have unsatisfactory long-term results. Furthermore, tectonic lamellar or penetrating keratoplasty (PK) is the most recommended treatment for most patients with extensive corneal lesions [27][28] .…”

Section: Keratoplastymentioning

confidence: 99%

Applications of SMILE-extracted lenticules in ophthalmology

Aghamollaei,

Fallahtafti,

Daryabari

et al. 2024

Int J Ophthalmol

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AIM: To review recent innovations, challenges, and applications of small incision lenticule extraction (SMILE) extracted lenticule for treating ocular disorders. METHODS: A literature review was performed in the PubMed database, which was last updated on 30 December 2021. There was no limit regarding language. The authors evaluated the reference lists of the collected papers to find any relevant research. RESULTS: Due to the simplicity and accuracy of modern femtosecond lasers and the extensive development of SMILE surgery, many healthy human corneal stromal lenticules were extracted during surgery, motivating some professionals to investigate the SMILE lenticule reusability in different ocular disorders. In addition, new approaches had been developed to preserve, modify, and bioengineer the corneal stroma, leading to the optimal use of discarded byproducts such as lenticules from SMILE surgery. The lenticules can be effectively re-implanted into the autologous or allogenic corneas of human subjects to treat refractive errors, corneal ectasia, and corneal perforation and serve as a patch graft for glaucoma drainage devices with better cosmetic outcomes. CONCLUSION: SMILE-extracted lenticules could be a viable alternative to human donor corneal tissue.

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