Scleral Ossification in Phthisical Eyes

Pecorella, Irene; Ciardi, Antonio; Grenga, Pier Luigi

doi:10.1080/01676830500505962

Cited by 12 publications

(10 citation statements)

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“…In the present study, scleral cartilage and bone were typically located adjacent and often dorsal to or surrounding the optic nerve head. This is similar to the position in which bone is described in the eyes of albino rats exposed to chronic stress, and in humans with organoid nevus syndrome, but not in humans with phthisical globes . The position of bone we discovered in goats is also remarkably similar to the os opticus, which has been described in 219 avian species from 35 families and nine orders .…”

Section: Discussionsupporting

confidence: 84%

“…Although bone, cartilage, or both occur as normal tissues within the sclera of many nonmammalian eyes and have been reported with various induced and spontaneous pathologic conditions in eyes of multiple species, to the authors’ knowledge, the present study is the first to report intrascleral bone development in the normal globe of a mammal of any type, and the first to characterize intrascleral cartilage as a normal finding in any therian. To the authors’ knowledge, there is only one previous report describing intrascleral cartilage in a single Suffolk ewe from the control group of a study looking at the effects of oral inoculation with scrapie .…”

Section: Discussionmentioning

confidence: 67%

“…To the authors’ knowledge, intrascleral cartilage or bone formation is reported very rarely in mammals that give live birth (therians) and, then, only in various experimental models, pathological conditions and aging in rats, mice grafted with avian retinal pigment epithelium, the organoid nevus syndrome in humans, and in chronically phthisical human globes . Osseous metaplasia is fairly common in nonscleral sites, including the aged canine lung (i.e., pneumoliths), several neoplasms (e.g., canine mixed mammary tumors or feline gastrointestinal adenocarcinomas), and intraocular sites (e.g., the canine uvea or the guinea pig ciliary body) .…”

Section: Introductionmentioning

confidence: 99%

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Gross, histologic, and computed tomographic characterization of nonpathological intrascleral cartilage and bone in the domestic goat (Capra aegagrus hircus)

Tusler

Good

Maggs

et al. 2016

Veterinary Ophthalmology

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Objective To characterize grossly, histologically, and via computed tomography (CT) the appearance of intrascleral cartilage, bone, or both in domestic goats with otherwise normal eyes and to correlate this with age, sex, and breed. Animals studied Sixty-eight domestic goats (89 eyes). Procedures Forty-nine formalin-fixed globes from 38 goats underwent high-resolution CT, and gross and light microscopic examination. An additional 40 eyes from 30 goats underwent light microscopy only. Age, breed, and sex of affected goats were retrieved from medical records.Results Considering all methods of evaluation collectively, cartilage was detected in 42% of eyes (44% of goats) and bone in 11% of eyes (12% of goats); bone was never seen without cartilage. Goats in which bone, cartilage, or both were detected ranged from 0.25 to 13 (median = 3.5) years of age, represented 11 of 12 breeds of the study population, and had a male:female ratio of 11:19. Bone was detected in the eyes of significantly more males (n = 8) than females (n = 2). No sex predilection was noted for cartilage alone. Histology revealed intrascleral chondrocyte-like cells, hyaline cartilage, and islands of lamellar bone. Some regions of bone had central, adipose-rich, marrowlike cavities. CT localized mineralized tissue as adjacent to or partially surrounding the optic nerve head. Conclusions This is the first report of intrascleral bone or cartilage in a normal goat and of intrascleral bone in an otherwise normal mammal. The high prevalence of intrascleral cartilage and bone in this study suggests that this finding is normal and likely represents an adaptation in goats.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 99%

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Gross, histologic, and computed tomographic characterization of nonpathological intrascleral cartilage and bone in the domestic goat (Capra aegagrus hircus)

Tusler

Good

Maggs

et al. 2016

Veterinary Ophthalmology

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“…18 Tüberküloz sklerit, nekrozis ve sonrasında skleromalaziye neden olabilir. 19 Tanıda en ideal yöntem basilin gözlenmesi veya üretilmesidir. Ancak doku içinde dağınık ve seyrek yerleşimi nedeniyle sklera veya orbitadan alınan numunelerde tespit edilmesi zordur.…”

Section: Discussionunclassified

Tüberkülozun nadir bir formu: Sklera tüberkülozu

Özdemir¹,

Gündüz²,

Emre³

et al. 2016

Ankara Med J

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ÖzGiriş: Göz organında tüberküloz en sık olarak hematojen yayılım sonucu oluşur. Tüberküloz, sklerit ve episkleritin nadir bir nedenidir. Olgu: 38 yaşında mesleği hemşire olan bayan hastada tüberkülozun nadir bir formu olan sklera tüberkülozu tanısı konuldu. Tartışma: Tüberküloz hastalarında oküler tutulum %1,39 ile %2.8 arasında değişmektedir. Oküler tutulum kalıcı görme sorunlarına neden olabildiği için, göz hastalıkları uzmanları enflamatuar göz hastalıklarında tüberkülozu düşünmeli ve ayırıcı tanıda yer vermemeleri durumunda ciddi sonuçların ortaya çıkabileceğinin farkında olmalıdırlar. Anahtar kelimeler: Tüberküloz, sklerit, tedavi Abstract Introduction: Tuberculosis of the eye is the most common results from hematogen spread. Tuberculosis is a rare causes of scleritis and episcleritis. Case: Thirty-eight years old female nurse was diagnosed with tuberculosis scleritis which is a rare form tuberculosis. Discussion: Eye involvement in tuberculosis patients varies between 1.39 % and 2.8%. In the presence of inflammatory eye disease ocular involvement of the tubercluosis should be considered by ophthalmologist because it can lead to permanent vision problems. It can lead to serious consequences if it is not considered in the differential diagnosis. GirişTüberküloz, sıklıkla plevrayı ve akciğeri tutmakla birlikte vücuttaki tüm diğer organlardan birini ya da birden fazlasını tutabilen bir hastalıktır. Kazeifikasyon nekrozu içeren granülom oluşumuna neden olabilmektedir. 1Akciğer dışı tüberküloz, en sık akciğer ya da akciğer dışı bir odaktan lenfohematojen yayılım ile oluşur. Akciğer dışı tüberkülozda tanısal zorluklar vardır. Bunun nedenleri; hastalığın sık görülmemesi, klinisyenlerin deneyimlerinin azlığı, hastalığın zor ulaşılabilir bölgelerde bulunması ve az sayıda basilin hastalık oluşturmasıdır. Tanı için genellikle invaziv girişimler gerekmektedir. 2 Özdemir ve ark.

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“…Tuberculous scleritis presents with localized focal elevated nodules of the sclera. This may undergo necrosis and may lead to scleromalacia [7,35]. Many of the cases of anterior segment ocular involvement are not associated with systemic manifestations of tuberculosis and appear to be localized to the eye [7] commonly with negative chest radiograph.…”

Section: Ocular Manifestations Of Tuberculosismentioning

confidence: 99%