Scleredema diabeticorum – A case report

Kyriakou, Aikaterini; Zagalioti, Sofia-Chrysovalantou; Lazaridou, Elizabeth; Patsatsi, Aikaterini

doi:10.4103/jfmpc.jfmpc_1489_20

Cited by 3 publications

(6 citation statements)

References 9 publications

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“…In the case of scleredema resulting from diabetes, the cause has been hypothesized to be irreversible collagen glycosylation, activation of fibroblasts for increased collagen and mucin production and their deposition in the dermis. Another hypothesis put forward is the activation of mucin and collagen production as a response to microvascular damage and subsequent hypoxia ( 27 ).…”

Section: Deposition Disordersmentioning

confidence: 99%

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Scleroderma and scleroderma-like syndromes

Romanowska-Próchnicka,

Dziewit,

Lesiak

et al. 2024

Front. Immunol.

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Systemic sclerosis is a systemic connective tissue disease whose main pathophysiological mechanism is a progressive fibrosis of internal organs and skin leading to thickening and induration. Blood vessels may also be involved. However, systemic scleroderma is not the only disease causing cutaneous sclerosis. There is a group of diseases that mimic scleroderma in their clinical presentation - these are scleroderma-like syndromes. A distinction can be made between syndromes of inflammatory/autoimmune, genetic, metabolic, toxic, drug-induced, occupational, paraneoplastic and syndromes caused by deposition disorders. In the following paper, we have reviewed the literature on scleroderma-like syndromes. We have outlined the factors predisposing to the development of each disease, its pathogenesis, clinical presentation, diagnostic and treatment process and the differences between each syndrome and systemic scleroderma.

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Section: Deposition Disordersmentioning

confidence: 99%

“…Abnormal amyloid is produced by the liver. It manifests with autonomic and peripheral neuropathy, vitreous opacity and heart failure due to cardiomyopathy ( 27 ).…”

Section: Deposition Disordersmentioning

confidence: 99%

Scleroderma and scleroderma-like syndromes

Romanowska-Próchnicka,

Dziewit,

Lesiak

et al. 2024

Front. Immunol.

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“…Systemic corticosteroid therapy is partially effective, but its duration of administration has been limited due to the risk of glycemic imbalance. Also, a partially favorable response was observed after electron beams radiotherapy and the administration of doxycycline and colchicines ( 36 , 131 ).…”

Section: Discussionmentioning

confidence: 99%

“…Scleredema diabeticorum is considered to be a skin syndrome associated with type 1 or type 2 diabetes in the context diabetic cheiroarthropathy ( 36 , 37 ). It is rarely seen and is manifested by the strengthening and stiffening of the skin and subcutaneous tissue on the nape of the neck and in the upper region of the posterior thorax, without manifestations in the spectrum of collagenosis.…”

Section: Discussionmentioning

confidence: 99%

Immunologic and nonimmunologic sclerodermal skin conditions - review

Bobeica,

Niculet,

Craescu

et al. 2023

Front. Immunol.

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Scleroderma-like cutaneous lesions have been found in many pathological conditions and they have the clinical appearance of sclerotic or scleroatrophic lesions. Affected skin biopsies described histopathological changes similar to those of scleroderma located strictly on the skin or those of systemic sclerosis. These skin lesions can be found in inflammatory diseases with autoimmune substrate (generalized morphea, chronic graft versus host disease, eosinophilic fasciitis), tissue storage diseases (scleredema, scleromyxedema, nephrogenyc systemic fibrosis, systemic amyloidosis), metabolic diseases (porphyrya cutanea tarda, phenylketonuria, hypothyroidism, scleredema diabeticorum), progeroid syndromes. Given the multiple etiologies of sclerodermal lesions, a correct differential diagnosis is necessary to establish the appropriate treatment.

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“…Type 1 scleredema (55%) is associated with streptococcal infection [ 2 ], type 2 scleredema (25%) is associated with paraproteinemia secondary to hematological malignancy [ 2 ], and type 3 is (3%) is scleredema diabeticorum (SD) [ 2 ]. SD is a rare complication of diabetes, which is mainly seen in type 2 DM but occasionally in type 1 DM as well [ 3 ]. Long-established poorly controlled DM with microvascular complications, obesity, and male gender are the recognized risk factors for SD [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Scleredema Diabeticorum: A Rare Metabolic Connective Tissue Manifestation of Type 2 Diabetes Mellitus Causing External Restrictive Lung Disease

Ranabahu,

Karunarathna,

Asanthi

et al. 2024

Cureus

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Scleredema diabeticorum (SD) is a rare metabolic connective tissue manifestation of diabetes mellitus (DM). SD commonly manifests in male patients with poorly controlled prolonged DM with obesity. In SD, the skin gets stiffened, thickened, and leathery in texture with a peau d’orange appearance commonly involving the posterior aspect of the neck and chest wall. Extensive chest wall skin involvement restricts lung movement, causing external restrictive lung disease and hypoventilation. In this case report, we present a 50-year-old male patient with poorly controlled type 2 DM for 10 years, complicated with established diabetic microvascular complications and extensive involvement of SD over the back of the neck and chest with external restrictive lung disease.

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Scleredema diabeticorum – A case report

Cited by 3 publications

References 9 publications

Scleroderma and scleroderma-like syndromes

Scleroderma and scleroderma-like syndromes

Immunologic and nonimmunologic sclerodermal skin conditions - review

Scleredema Diabeticorum: A Rare Metabolic Connective Tissue Manifestation of Type 2 Diabetes Mellitus Causing External Restrictive Lung Disease

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